EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells Article Swipe
Yuki Tanaka
,
Yasunobu Arima
,
Kotaro Higuchi
,
Takuto Ohki
,
Mohamed Elfeky
,
Mitsutoshi Ota
,
Daisuke Kamimura
,
Masaaki Murakami
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.21769/bioprotoc.2370
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.21769/bioprotoc.2370
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), which is a chronic inflammatory disease of the central nervous system (CNS). It is characterized by focal demyelination and inflammatory responses mediated by myelin-specific autoreactive CD4+ T cells. Using a passive transfer model of EAE in mice, we have demonstrated that regional specific neural signals by sensory-sympathetic communications create gateways for immune cells at specific blood vessels of the CNS, a phenomenon known as the gateway reflex ( Arima et al., 2012 ; Tracey, 2012; Arima et al., 2013 ; Sabharwal et al., 2014 ; Arima et al., 2015b ). Here we describe protocols for passive transfer model of EAE using freshly isolated (MOG)-specific CD4+ T cells or periodically restimulated MOG-specific CD4+ T cell lines, which are suitable for tracking pathogenic CD4+ T cells in vivo, particularly in the CNS ( Ogura et al., 2008 ; Arima et al., 2012 and 2015b).
Related Topics
Concepts
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Encephalomyelitis
Biology
Immunology
Neuroscience
Immune system
Myelin oligodendrocyte glycoprotein
Central nervous system
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.21769/bioprotoc.2370
- OA Status
- green
- Cited By
- 16
- References
- 18
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2732251601
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2732251601Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21769/bioprotoc.2370Digital Object Identifier
- Title
-
EAE Induction by Passive Transfer of MOG-specific CD4+ T CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-01-01Full publication date if available
- Authors
-
Yuki Tanaka, Yasunobu Arima, Kotaro Higuchi, Takuto Ohki, Mohamed Elfeky, Mitsutoshi Ota, Daisuke Kamimura, Masaaki MurakamiList of authors in order
- Landing page
-
https://doi.org/10.21769/bioprotoc.2370Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8413655Direct OA link when available
- Concepts
-
Experimental autoimmune encephalomyelitis, Multiple sclerosis, Encephalomyelitis, Biology, Immunology, Neuroscience, Immune system, Myelin oligodendrocyte glycoprotein, Central nervous systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
16Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 7, 2023: 3, 2019: 3, 2018: 2Per-year citation counts (last 5 years)
- References (count)
-
18Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2732251601 |
|---|---|
| doi | https://doi.org/10.21769/bioprotoc.2370 |
| ids.doi | https://doi.org/10.21769/bioprotoc.2370 |
| ids.mag | 2732251601 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/34541112 |
| ids.openalex | https://openalex.org/W2732251601 |
| fwci | 0.82440091 |
| type | article |
| title | EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells |
| biblio.issue | 13 |
| biblio.volume | 7 |
| biblio.last_page | e2370 |
| biblio.first_page | e2370 |
| topics[0].id | https://openalex.org/T11266 |
| topics[0].field.id | https://openalex.org/fields/28 |
| topics[0].field.display_name | Neuroscience |
| topics[0].score | 0.9987999796867371 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2808 |
| topics[0].subfield.display_name | Neurology |
| topics[0].display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| topics[1].id | https://openalex.org/T12580 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9973999857902527 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2808 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Vagus Nerve Stimulation Research |
| topics[2].id | https://openalex.org/T10137 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9965999722480774 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2734 |
| topics[2].subfield.display_name | Pathology and Forensic Medicine |
| topics[2].display_name | Multiple Sclerosis Research Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2778486448 |
| concepts[0].level | 3 |
| concepts[0].score | 0.8608638048171997 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q494066 |
| concepts[0].display_name | Experimental autoimmune encephalomyelitis |
| concepts[1].id | https://openalex.org/C2780640218 |
| concepts[1].level | 2 |
| concepts[1].score | 0.675089955329895 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q8277 |
| concepts[1].display_name | Multiple sclerosis |
| concepts[2].id | https://openalex.org/C2777899865 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5160791277885437 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1634879 |
| concepts[2].display_name | Encephalomyelitis |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5042251348495483 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C203014093 |
| concepts[4].level | 1 |
| concepts[4].score | 0.47254371643066406 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[4].display_name | Immunology |
| concepts[5].id | https://openalex.org/C169760540 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4633399248123169 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[5].display_name | Neuroscience |
| concepts[6].id | https://openalex.org/C8891405 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4558317959308624 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[6].display_name | Immune system |
| concepts[7].id | https://openalex.org/C2779357208 |
| concepts[7].level | 4 |
| concepts[7].score | 0.4483616352081299 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q6947292 |
| concepts[7].display_name | Myelin oligodendrocyte glycoprotein |
| concepts[8].id | https://openalex.org/C529278444 |
| concepts[8].level | 2 |
| concepts[8].score | 0.41984331607818604 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q47273 |
| concepts[8].display_name | Central nervous system |
| keywords[0].id | https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis |
| keywords[0].score | 0.8608638048171997 |
| keywords[0].display_name | Experimental autoimmune encephalomyelitis |
| keywords[1].id | https://openalex.org/keywords/multiple-sclerosis |
| keywords[1].score | 0.675089955329895 |
| keywords[1].display_name | Multiple sclerosis |
| keywords[2].id | https://openalex.org/keywords/encephalomyelitis |
| keywords[2].score | 0.5160791277885437 |
| keywords[2].display_name | Encephalomyelitis |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.5042251348495483 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/immunology |
| keywords[4].score | 0.47254371643066406 |
| keywords[4].display_name | Immunology |
| keywords[5].id | https://openalex.org/keywords/neuroscience |
| keywords[5].score | 0.4633399248123169 |
| keywords[5].display_name | Neuroscience |
| keywords[6].id | https://openalex.org/keywords/immune-system |
| keywords[6].score | 0.4558317959308624 |
| keywords[6].display_name | Immune system |
| keywords[7].id | https://openalex.org/keywords/myelin-oligodendrocyte-glycoprotein |
| keywords[7].score | 0.4483616352081299 |
| keywords[7].display_name | Myelin oligodendrocyte glycoprotein |
| keywords[8].id | https://openalex.org/keywords/central-nervous-system |
| keywords[8].score | 0.41984331607818604 |
| keywords[8].display_name | Central nervous system |
| language | en |
| locations[0].id | doi:10.21769/bioprotoc.2370 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S4210179406 |
| locations[0].source.issn | 2331-8325 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2331-8325 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | BIO-PROTOCOL |
| locations[0].source.host_organization | https://openalex.org/P4310320252 |
| locations[0].source.host_organization_name | American Academy of Arts and Sciences |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320252 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | BIO-PROTOCOL |
| locations[0].landing_page_url | https://doi.org/10.21769/bioprotoc.2370 |
| locations[1].id | pmid:34541112 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Bio-protocol |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/34541112 |
| locations[2].id | pmh:oai:europepmc.org:7337770 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306400806 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | Europe PMC (PubMed Central) |
| locations[2].source.host_organization | https://openalex.org/I1303153112 |
| locations[2].source.host_organization_name | European Bioinformatics Institute |
| locations[2].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | http://europepmc.org/pmc/articles/PMC8413655 |
| locations[3].id | pmh:oai:doaj.org/article:9528b4d9c0264ed78f4c647e4ff06c52 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Bio-Protocol, Vol 7, Iss 13 (2017) |
| locations[3].landing_page_url | https://doaj.org/article/9528b4d9c0264ed78f4c647e4ff06c52 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:8413655 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Bio Protoc |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8413655 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5101794234 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-9822-9804 |
| authorships[0].author.display_name | Yuki Tanaka |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[0].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I205349734 |
| authorships[0].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Hokkaido University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yuki Tanaka |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[1].author.id | https://openalex.org/A5102766449 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-4149-7821 |
| authorships[1].author.display_name | Yasunobu Arima |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I205349734 |
| authorships[1].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Hokkaido University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yasunobu Arima |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[2].author.id | https://openalex.org/A5106085642 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Kotaro Higuchi |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I205349734 |
| authorships[2].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Hokkaido University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Kotaro Higuchi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[3].author.id | https://openalex.org/A5102170543 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Takuto Ohki |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I205349734 |
| authorships[3].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Hokkaido University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Takuto Ohki |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[4].author.id | https://openalex.org/A5078805140 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8812-466X |
| authorships[4].author.display_name | Mohamed Elfeky |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I205349734 |
| authorships[4].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Hokkaido University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Mohamed Elfeky |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[5].author.id | https://openalex.org/A5102836206 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7108-9730 |
| authorships[5].author.display_name | Mitsutoshi Ota |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[5].institutions[0].id | https://openalex.org/I205349734 |
| authorships[5].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Hokkaido University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Mitsutoshi Ota |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[6].author.id | https://openalex.org/A5063407770 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-1022-4430 |
| authorships[6].author.display_name | Daisuke Kamimura |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[6].institutions[0].id | https://openalex.org/I205349734 |
| authorships[6].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Hokkaido University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Daisuke Kamimura |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[7].author.id | https://openalex.org/A5068093589 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-7544-9791 |
| authorships[7].author.display_name | Masaaki Murakami |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I205349734 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| authorships[7].institutions[0].id | https://openalex.org/I205349734 |
| authorships[7].institutions[0].ror | https://ror.org/02e16g702 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I205349734 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Hokkaido University |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Masaaki Murakami |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Molecular Neuroimmunology, Institute for Genetic Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8413655 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | EAE Induction by Passive Transfer of MOG-specific CD4+ T Cells |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11266 |
| primary_topic.field.id | https://openalex.org/fields/28 |
| primary_topic.field.display_name | Neuroscience |
| primary_topic.score | 0.9987999796867371 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2808 |
| primary_topic.subfield.display_name | Neurology |
| primary_topic.display_name | Neuroinflammation and Neurodegeneration Mechanisms |
| related_works | https://openalex.org/W2995289115, https://openalex.org/W2749200642, https://openalex.org/W1986409517, https://openalex.org/W2048700200, https://openalex.org/W2131887019, https://openalex.org/W2015637511, https://openalex.org/W2331526913, https://openalex.org/W2088868476, https://openalex.org/W2790783330, https://openalex.org/W2951067766 |
| cited_by_count | 16 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 7 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 3 |
| counts_by_year[3].year | 2019 |
| counts_by_year[3].cited_by_count | 3 |
| counts_by_year[4].year | 2018 |
| counts_by_year[4].cited_by_count | 2 |
| locations_count | 5 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:8413655 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | Bio Protoc |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8413655 |
| primary_location.id | doi:10.21769/bioprotoc.2370 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S4210179406 |
| primary_location.source.issn | 2331-8325 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2331-8325 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | BIO-PROTOCOL |
| primary_location.source.host_organization | https://openalex.org/P4310320252 |
| primary_location.source.host_organization_name | American Academy of Arts and Sciences |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320252 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | BIO-PROTOCOL |
| primary_location.landing_page_url | https://doi.org/10.21769/bioprotoc.2370 |
| publication_date | 2017-01-01 |
| publication_year | 2017 |
| referenced_works | https://openalex.org/W2055254020, https://openalex.org/W2118730986, https://openalex.org/W2109510323, https://openalex.org/W1836377684, https://openalex.org/W2117503790, https://openalex.org/W2040547343, https://openalex.org/W1594197304, https://openalex.org/W2399359399, https://openalex.org/W2522327693, https://openalex.org/W2153642626, https://openalex.org/W1989588757, https://openalex.org/W1713072060, https://openalex.org/W2159252214, https://openalex.org/W2107906835, https://openalex.org/W1984735835, https://openalex.org/W2105367260, https://openalex.org/W2039544748, https://openalex.org/W2084542053 |
| referenced_works_count | 18 |
| abstract_inverted_index.( | 79, 142 |
| abstract_inverted_index.; | 84, 91, 96, 147 |
| abstract_inverted_index.T | 38, 117, 124, 134 |
| abstract_inverted_index.a | 14, 41, 72 |
| abstract_inverted_index.). | 101 |
| abstract_inverted_index.It | 24 |
| abstract_inverted_index.an | 5 |
| abstract_inverted_index.as | 75 |
| abstract_inverted_index.at | 65 |
| abstract_inverted_index.by | 27, 34, 57 |
| abstract_inverted_index.in | 47, 139 |
| abstract_inverted_index.is | 4, 13, 25 |
| abstract_inverted_index.of | 8, 18, 45, 69, 110 |
| abstract_inverted_index.or | 119 |
| abstract_inverted_index.we | 49, 103 |
| abstract_inverted_index.CNS | 141 |
| abstract_inverted_index.EAE | 46, 111 |
| abstract_inverted_index.and | 30, 152 |
| abstract_inverted_index.are | 128 |
| abstract_inverted_index.for | 62, 106, 130 |
| abstract_inverted_index.the | 19, 70, 76, 140 |
| abstract_inverted_index.2008 | 146 |
| abstract_inverted_index.2012 | 83, 151 |
| abstract_inverted_index.2013 | 90 |
| abstract_inverted_index.2014 | 95 |
| abstract_inverted_index.CNS, | 71 |
| abstract_inverted_index.Here | 102 |
| abstract_inverted_index.cell | 125 |
| abstract_inverted_index.have | 50 |
| abstract_inverted_index.that | 52 |
| abstract_inverted_index.(EAE) | 3 |
| abstract_inverted_index.(MS), | 11 |
| abstract_inverted_index.2012; | 86 |
| abstract_inverted_index.2015b | 100 |
| abstract_inverted_index.<i>et | 81, 88, 93, 98, 144, 149 |
| abstract_inverted_index.<i>in | 136 |
| abstract_inverted_index.Arima | 80, 87, 97, 148 |
| abstract_inverted_index.Ogura | 143 |
| abstract_inverted_index.Using | 40 |
| abstract_inverted_index.blood | 67 |
| abstract_inverted_index.cells | 64, 118, 135 |
| abstract_inverted_index.focal | 28 |
| abstract_inverted_index.known | 74 |
| abstract_inverted_index.mice, | 48 |
| abstract_inverted_index.model | 7, 44, 109 |
| abstract_inverted_index.using | 112 |
| abstract_inverted_index.which | 12, 127 |
| abstract_inverted_index.(CNS). | 23 |
| abstract_inverted_index.animal | 6 |
| abstract_inverted_index.cells. | 39 |
| abstract_inverted_index.create | 60 |
| abstract_inverted_index.immune | 63 |
| abstract_inverted_index.lines, | 126 |
| abstract_inverted_index.neural | 55 |
| abstract_inverted_index.reflex | 78 |
| abstract_inverted_index.system | 22 |
| abstract_inverted_index.2015b). | 153 |
| abstract_inverted_index.Tracey, | 85 |
| abstract_inverted_index.central | 20 |
| abstract_inverted_index.chronic | 15 |
| abstract_inverted_index.disease | 17 |
| abstract_inverted_index.freshly | 113 |
| abstract_inverted_index.gateway | 77 |
| abstract_inverted_index.nervous | 21 |
| abstract_inverted_index.passive | 42, 107 |
| abstract_inverted_index.signals | 56 |
| abstract_inverted_index.vessels | 68 |
| abstract_inverted_index.al.</i>, | 82, 89, 94, 99, 145, 150 |
| abstract_inverted_index.describe | 104 |
| abstract_inverted_index.gateways | 61 |
| abstract_inverted_index.isolated | 114 |
| abstract_inverted_index.mediated | 33 |
| abstract_inverted_index.multiple | 9 |
| abstract_inverted_index.regional | 53 |
| abstract_inverted_index.specific | 54, 66 |
| abstract_inverted_index.suitable | 129 |
| abstract_inverted_index.tracking | 131 |
| abstract_inverted_index.transfer | 43, 108 |
| abstract_inverted_index.Sabharwal | 92 |
| abstract_inverted_index.protocols | 105 |
| abstract_inverted_index.responses | 32 |
| abstract_inverted_index.sclerosis | 10 |
| abstract_inverted_index.vivo</i>, | 137 |
| abstract_inverted_index.autoimmune | 1 |
| abstract_inverted_index.pathogenic | 132 |
| abstract_inverted_index.phenomenon | 73 |
| abstract_inverted_index.Experimental | 0 |
| abstract_inverted_index.MOG-specific | 122 |
| abstract_inverted_index.autoreactive | 36 |
| abstract_inverted_index.demonstrated | 51 |
| abstract_inverted_index.inflammatory | 16, 31 |
| abstract_inverted_index.particularly | 138 |
| abstract_inverted_index.periodically | 120 |
| abstract_inverted_index.restimulated | 121 |
| abstract_inverted_index.characterized | 26 |
| abstract_inverted_index.demyelination | 29 |
| abstract_inverted_index.(MOG)-specific | 115 |
| abstract_inverted_index.communications | 59 |
| abstract_inverted_index.CD4<sup>+</sup> | 37, 116, 123, 133 |
| abstract_inverted_index.myelin-specific | 35 |
| abstract_inverted_index.encephalomyelitis | 2 |
| abstract_inverted_index.sensory-sympathetic | 58 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7400000095367432 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.71548234 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |