Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk Article Swipe

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Berglind Jónsdóttir , Joanna Clasen , Kendra Vehik , Åke Lernmark , Markus Lundgren , Ezio Bonifacio , Desmond Schatz , Anette-Gabriele Ziegler , William Hagopian , Marian Rewers , Richard McIndoe , Jorma Toppari , Jeffrey Krischer , Beena Akolkar , Andrea K. Steck , Riitta Veijola , Michael J. Haller , Helena Elding Larsson , Marian Rewers , Kimberly Bautista , Judith Baxter , Daniel Felipe-Morales , Brigitte I. Frohnert , Marisa Stahl , Isabel Flores Garcia , Patricia Gesualdo , Sierra Hays , Michelle Hoffman , R. Johnson , Rachel Karban , Edwin Liu , Leila Loaiza , Jill M. Norris , Holly O’Donnell , Loana Thorndahl , Andrea K. Steck , Kathleen Waugh , Jorma Toppari , Olli Simell , Annika Adamsson , Suvi Ahonen , Iris Erlund , Sirpa Anttila , Leena Hakola , Anne Hekkala , Tiia Honkanen , T Hurskainen , Heikki Hyöty , Jorma Ilonen , Saori Itoshima , Minna Jokipolvi , Sanna Jokipuu , Taru Karjalainen , Leena Eklund Karlsson , Jukka Kero , Marika Korpela , Jaakko J. Koskenniemi , Miia Kähönen , Mikael Knip , Minna-Liisa Koivikko , Katja Kokkonen , Merja Koskinen , Mirva Koreasalo , Kalle Kurppa , Salla Kuusela , Jarita Kytölä , Mia Laakso , Jutta E. Laiho , Tiina Latva-aho , Siiri Leisku , Laura Leppänen , Katri Lindfors , Maria Lönnrot , Elina Mäntymäki , Markus Mattila , Maija E. Miettinen , Tiina Niininen , Sari Niinistö , Noora Nurminen , Sami Oikarinen , Hanna-Leena Oinas , Paula Ollikainen , Zhian Othmani , Sirpa Pohjola , Solja Raja-Hanhela , Jenna Rautanen , Anne Riikonen , Minna Romo , Juulia Rönkä , Nelli Rönkä , Satu Simell , Aino Tihinen , Päivi Tossavainen , Mari Vähä-Mäkilä , Eeva Varjonen , Riitta Veijola , Irene Viinikangas , Silja Vilmi , Suvi Μ. Virtanen , Richard McIndoe ·

YOU? · · 2024 · Open Access · · DOI: https://doi.org/10.1210/clinem/dgae478

Context Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune thyroid disease (AITD), which can progress to either clinical hypothyroidism or hyperthyroidism. Objective We determined the age at seroconversion in children genetically at risk for type 1 diabetes. Methods TPOAb and TgAb seropositivity were determined in 5066 healthy children with human leukocyte antigen (HLA) DR3- or DR4-containing haplogenotypes from The Environmental Determinants of Diabetes in the Young (TEDDY) study. Children seropositive on the cross-sectional initial screen at age 8 to 13 years had longitudinally collected samples (from age 3.5 months) screened retrospectively and prospectively for thyroid autoantibodies to identify age at seroconversion. The first-appearing autoantibody was related to sex, HLA genotype, family history of AITD, and subsequent thyroid dysfunction and disease. Results The youngest appearance of TPOAb and TgAb was age 10 and 15 months, respectively. Girls had higher incidence rates of both autoantibodies. Family history of AITD was associated with a higher risk of TPOAb hazard ratio (HR) 1.90; 95% CI, 1.17-3.08; and TgAb HR 2.55; 95% CI, 1.91-3.41. The risk of progressing to hypothyroidism or hyperthyroidism was not different between TgAb and TPOAb, but children with both autoantibodies appearing at the same visit had a higher risk compared to TPOAb appearing first (HR 6.34; 95% CI, 2.72-14.76). Conclusion Thyroid autoantibodies may appear during the first years of life, especially in girls, and in children with a family history of AITD. Simultaneous appearance of both autoantibodies increases the risk for hypothyroidism or hyperthyroidism.

Related Topics

Hashimoto's Thyroiditis

Concepts

Medicine Autoantibody Thyroid peroxidase Family history Internal medicine Type 1 diabetes Anti-thyroid autoantibodies Thyroiditis Thyroid Thyroglobulin Endocrinology Diabetes mellitus Pediatrics Immunology Antibody

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Type: article
Language: en
Landing Page: https://doi.org/10.1210/clinem/dgae478
PDF: https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgae478/58704021/dgae478.pdf
OA Status: hybrid
Cited By: 2
References: 38
Related Works: 10
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DOI: https://doi.org/10.1210/clinem/dgae478

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Title: Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk

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Language: en

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Publication year: 2024

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Publication date: 2024-07-10

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Authors: Berglind Jónsdóttir, Joanna Clasen, Kendra Vehik, Åke Lernmark, Markus Lundgren, Ezio Bonifacio, Desmond Schatz, Anette-Gabriele Ziegler, William Hagopian, Marian Rewers, Richard McIndoe, Jorma Toppari, Jeffrey Krischer, Beena Akolkar, Andrea K. Steck, Riitta Veijola, Michael J. Haller, Helena Elding Larsson, Marian Rewers, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Isabel Flores Garcia, Patricia Gesualdo, Sierra Hays, Michelle Hoffman, R. Johnson, Rachel Karban, Edwin Liu, Leila Loaiza, Jill M. Norris, Holly O’Donnell, Loana Thorndahl, Andrea K. Steck, Kathleen Waugh, Jorma Toppari, Olli Simell, Annika Adamsson, Suvi Ahonen, Iris Erlund, Sirpa Anttila, Leena Hakola, Anne Hekkala, Tiia Honkanen, T Hurskainen, Heikki Hyöty, Jorma Ilonen, Saori Itoshima, Minna Jokipolvi, Sanna Jokipuu, Taru Karjalainen, Leena Eklund Karlsson, Jukka Kero, Marika Korpela, Jaakko J. Koskenniemi, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jarita Kytölä, Mia Laakso, Jutta E. Laiho, Tiina Latva-aho, Siiri Leisku, Laura Leppänen, Katri Lindfors, Maria Lönnrot, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Tiina Niininen, Sari Niinistö, Noora Nurminen, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Sirpa Pohjola, Solja Raja-Hanhela, Jenna Rautanen, Anne Riikonen, Minna Romo, Juulia Rönkä, Nelli Rönkä, Satu Simell, Aino Tihinen, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Riitta Veijola, Irene Viinikangas, Silja Vilmi, Suvi Μ. Virtanen, Richard McIndoe

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Landing page: https://doi.org/10.1210/clinem/dgae478

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Concepts: Medicine, Autoantibody, Thyroid peroxidase, Family history, Internal medicine, Type 1 diabetes, Anti-thyroid autoantibodies, Thyroiditis, Thyroid, Thyroglobulin, Endocrinology, Diabetes mellitus, Pediatrics, Immunology, Antibody

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Cited by: 2

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