Early Hyperoxia in The Intensive Care Unit is Significantly Associated With Unfavorable Neurological Outcomes in Patients With Mild-to-Moderate Aneurysmal Subarachnoid Hemorrhage Article Swipe
Shota Yokoyama
,
Toru Hifumi
,
Kenya Kawakita
,
Takashi Tamiya
,
Tetsuo Minamino
,
Yasuhiro Kuroda
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000001221
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1097/shk.0000000000001221
Introduction: Although oxygen administration is fundamental in the management of aneurysmal subarachnoid hemorrhage (SAH) patients in the acute stage, hyperoxia has harmful effects. The effects of hyperoxia on neurological outcomes in SAH patients are unclear. We aimed to examine the association of hyperoxia during the first 24 h in the intensive care unit (ICU) with unfavorable neurological outcomes in SAH patients. Methods: We retrospectively selected consecutive adult patients admitted to ICU for SAH between January 2009 and April 2018. We defined normoxia during the first 24 h in ICU as PaO 2 of 60 mm Hg to 120 mm Hg, mild hyperoxia as PaO 2 of 121 mm Hg to 200 mm Hg, moderate hyperoxia as PaO 2 of 201 mm Hg to 300 mm Hg, and severe hyperoxia as PaO 2 of >300 mm Hg. Univariate and multivariate analyses were performed to examine the association between hyperoxia during the first 24 h in ICU and unfavorable neurological outcomes (i.e., modified Rankin scale score of 3–6 at hospital discharge). Results: Among 196 SAH patients, 90 had unfavorable neurological outcomes. Hyperoxia was observed in 93.4% of patients. No significant association was observed between unfavorable neurological outcomes and hyperoxia in overall patients. However, we found that early hyperoxia in ICU was significantly associated with unfavorable neurological outcomes in SAH patients with Hunt and Kosnik (H&K) grades I to III (Relative risk, 1.84; 95% confidence interval, 1.10–2.94; P = 0.02). Conclusions: Early hyperoxia was not associated with unfavorable neurological outcomes in overall SAH patients, but it was associated with unfavorable neurological outcomes in those with H&K grades I to III.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/shk.0000000000001221
- http://links.lww.com/SHK/A787
- OA Status
- bronze
- Cited By
- 29
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2886826888
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2886826888Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1097/shk.0000000000001221Digital Object Identifier
- Title
-
Early Hyperoxia in The Intensive Care Unit is Significantly Associated With Unfavorable Neurological Outcomes in Patients With Mild-to-Moderate Aneurysmal Subarachnoid HemorrhageWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-08-01Full publication date if available
- Authors
-
Shota Yokoyama, Toru Hifumi, Kenya Kawakita, Takashi Tamiya, Tetsuo Minamino, Yasuhiro KurodaList of authors in order
- Landing page
-
https://doi.org/10.1097/shk.0000000000001221Publisher landing page
- PDF URL
-
https://links.lww.com/SHK/A787Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://links.lww.com/SHK/A787Direct OA link when available
- Concepts
-
Hyperoxia, Medicine, Subarachnoid hemorrhage, Intensive care unit, Anesthesia, Univariate analysis, Modified Rankin Scale, Glasgow Coma Scale, Internal medicine, Multivariate analysis, Ischemia, Lung, Ischemic strokeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
29Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 5, 2023: 4, 2022: 6, 2021: 4Per-year citation counts (last 5 years)
- References (count)
-
33Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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