Early parkinson’s disease: levodopa requirements are associated with the striatal DaT-uptake Article Swipe
Katarina Rukavina
,
Nicola Mulholland
,
Ben Corcoran
,
Magdalena Krbot Skorić
,
Silvia Rota
,
Alexandra Rizos
,
К. Ray Chaudhuri
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00702-025-02999-9
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1007/s00702-025-02999-9
Precision medicine driven by clinical biomarkers is the state-of-art management approach for Parkinson's disease (PD). Whether pattern of striatal dopaminergic deficiency (demonstrated by single-photon emission CT (SPECT) scanning with 123 I-Ioflupane, DaTSCAN ) could be a biomarker predicting levodopa requirement in early PD is not known. Participants with early PD (disease duration (DD) ≤ 5 years, Hoehn and Yahr (H&Y) ≤ 3) who underwent DaTSCAN as a part of clinical-diagnostic work up and were enrolled in the “Non-motor Longitudinal International Study” (UK National Institute for Health Research Clinical Research Network Number 10084) were included in this cross-sectional analysis. Specific DaTSCAN binding ratios were analyzed for each striatum, caudate nucleus and putamen and the z-scores were derived normalizing the images to age and gender-matched healthy controls from the European-Database-of-DaTSCAN-of-healthy-controls (ENC-DAT). Using linear regression analysis, we explored the impact of DaT-uptake z-scores for more severely affected putamen, caudate nucleus and striatum on the LEDD. Statistically significant predictors identified in the univariable analysis were included in the multivariable analysis with DD and H&Y as additional independent variables. 43 PwP (30% female; age: 61.91 ± 11.45years; DD: 2(0–5) years; H&Y: 2(1–3); LEDD: 424.27 ± 342.62 mg) were assessed 19.12 ± 13.11 months following the DaTSCAN. In a multivariable linear regression analysis, when adjusted for DD and H&Y, z-caudate nucleus (B=-134.073, 95% CI -262.715 - -5.431, p = 0.042) and z-striatum (B=-162.137, 95% CI -306.306 - -17.967, p = 0.028), were statistically significant predictors of LEDD, while z-putamen was not ( p = 0.086). In early PD, striatal DaT-uptake z-scores may serve as biomarkers that could aid the LEDD estimation and guide treatment decisions towards personalized care.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s00702-025-02999-9
- https://link.springer.com/content/pdf/10.1007/s00702-025-02999-9.pdf
- OA Status
- hybrid
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413257247
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4413257247Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s00702-025-02999-9Digital Object Identifier
- Title
-
Early parkinson’s disease: levodopa requirements are associated with the striatal DaT-uptakeWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-16Full publication date if available
- Authors
-
Katarina Rukavina, Nicola Mulholland, Ben Corcoran, Magdalena Krbot Skorić, Silvia Rota, Alexandra Rizos, К. Ray ChaudhuriList of authors in order
- Landing page
-
https://doi.org/10.1007/s00702-025-02999-9Publisher landing page
- PDF URL
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https://link.springer.com/content/pdf/10.1007/s00702-025-02999-9.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://link.springer.com/content/pdf/10.1007/s00702-025-02999-9.pdfDirect OA link when available
- Concepts
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Putamen, Caudate nucleus, Striatum, Levodopa, Parkinson's disease, Neurology, Dopaminergic, Internal medicine, Medicine, Disease, Gastroenterology, Psychology, Endocrinology, Dopamine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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