Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures Article Swipe
Hsuan Chih Liu
,
Ya-Han Chan
,
Shao-Fu Huang
,
Wei‐Che Tsai
,
Yu‐Ting Cheng
,
Chun‐Li Lin
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s41205-025-00278-7
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1186/s41205-025-00278-7
This study introduces an advanced framework that integrates biphasic cell differentiation bone remodeling theory with finite element (FE) analysis and multi-remodeling simulation to evaluate the performance of 3D-printed biodegradable scaffolds for bone defect repair. The program incorporates a time-dependent cell differentiation stimulus (S), accounting for fluid-phase shear stress and solid-phase shear strain, to dynamically predict bone cell behavior. The study focuses on polylactic acid (PLA) and polycaprolactone (PCL) scaffolds with diamond (DU) and random (YM) lattice designs, applied to a dorsal double-plating (DDP) fixation model for distal radius fractures. Material testing reveals that PLA provides higher rigidity and strength, while PCL offers superior ductility. Mechanical strength tests confirm the superior performance of DU lattice structures under compression, shear, and torsion forces. The bone remodeling program, applied to 36 model combinations of fracture gaps, materials, and lattice designs, computes the total percentage of cell differentiation (TPCD), identifying scaffold material as the key factor, with PLA significantly enhancing TPCD values. Biomechanical analysis after 50 remodeling iterations in a 5.4 mm fracture gap shows that the PLA + DU scaffold reduces displacement by 35%/39%/75%, bone stress by 19%/16%/67%, and fixation plate stress by 77%/66%/93% under axial/bending/torsion loads, respectively, compared to the PCL + YM scaffold. This study highlights the critical role of dynamic remodeling programs in optimizing scaffold material properties and lattice architectures, establishing a robust platform for patient-specific bone repair solutions in regenerative medicine.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s41205-025-00278-7
- https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7
- OA Status
- gold
- Cited By
- 1
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411461352
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4411461352Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s41205-025-00278-7Digital Object Identifier
- Title
-
Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fracturesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-06-19Full publication date if available
- Authors
-
Hsuan Chih Liu, Ya-Han Chan, Shao-Fu Huang, Wei‐Che Tsai, Yu‐Ting Cheng, Chun‐Li LinList of authors in order
- Landing page
-
https://doi.org/10.1186/s41205-025-00278-7Publisher landing page
- PDF URL
-
https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7Direct OA link when available
- Concepts
-
Scaffold, Materials science, Biomedical engineering, Polycaprolactone, 3d printed, Mechanobiology, Composite material, Anatomy, Engineering, Medicine, PolymerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4411461352 |
|---|---|
| doi | https://doi.org/10.1186/s41205-025-00278-7 |
| ids.doi | https://doi.org/10.1186/s41205-025-00278-7 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40536605 |
| ids.openalex | https://openalex.org/W4411461352 |
| fwci | 4.6013505 |
| type | article |
| title | Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures |
| biblio.issue | 1 |
| biblio.volume | 11 |
| biblio.last_page | 30 |
| biblio.first_page | 30 |
| topics[0].id | https://openalex.org/T10658 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9991999864578247 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Bone fractures and treatments |
| topics[1].id | https://openalex.org/T10630 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9987000226974487 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2746 |
| topics[1].subfield.display_name | Surgery |
| topics[1].display_name | Orthopedic Surgery and Rehabilitation |
| topics[2].id | https://openalex.org/T11562 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9970999956130981 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Facial Trauma and Fracture Management |
| is_xpac | False |
| apc_list.value | 1190 |
| apc_list.currency | GBP |
| apc_list.value_usd | 1459 |
| apc_paid.value | 1190 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 1459 |
| concepts[0].id | https://openalex.org/C89429830 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6591433882713318 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q735710 |
| concepts[0].display_name | Scaffold |
| concepts[1].id | https://openalex.org/C192562407 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6578664779663086 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q228736 |
| concepts[1].display_name | Materials science |
| concepts[2].id | https://openalex.org/C136229726 |
| concepts[2].level | 1 |
| concepts[2].score | 0.491939514875412 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q327092 |
| concepts[2].display_name | Biomedical engineering |
| concepts[3].id | https://openalex.org/C2779868350 |
| concepts[3].level | 3 |
| concepts[3].score | 0.4492727816104889 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q109674 |
| concepts[3].display_name | Polycaprolactone |
| concepts[4].id | https://openalex.org/C3019308078 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4428703784942627 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q229367 |
| concepts[4].display_name | 3d printed |
| concepts[5].id | https://openalex.org/C2780171871 |
| concepts[5].level | 2 |
| concepts[5].score | 0.44099509716033936 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q6804676 |
| concepts[5].display_name | Mechanobiology |
| concepts[6].id | https://openalex.org/C159985019 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3176083564758301 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q181790 |
| concepts[6].display_name | Composite material |
| concepts[7].id | https://openalex.org/C105702510 |
| concepts[7].level | 1 |
| concepts[7].score | 0.14592519402503967 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q514 |
| concepts[7].display_name | Anatomy |
| concepts[8].id | https://openalex.org/C127413603 |
| concepts[8].level | 0 |
| concepts[8].score | 0.10755467414855957 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11023 |
| concepts[8].display_name | Engineering |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C521977710 |
| concepts[10].level | 2 |
| concepts[10].score | 0.0 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q81163 |
| concepts[10].display_name | Polymer |
| keywords[0].id | https://openalex.org/keywords/scaffold |
| keywords[0].score | 0.6591433882713318 |
| keywords[0].display_name | Scaffold |
| keywords[1].id | https://openalex.org/keywords/materials-science |
| keywords[1].score | 0.6578664779663086 |
| keywords[1].display_name | Materials science |
| keywords[2].id | https://openalex.org/keywords/biomedical-engineering |
| keywords[2].score | 0.491939514875412 |
| keywords[2].display_name | Biomedical engineering |
| keywords[3].id | https://openalex.org/keywords/polycaprolactone |
| keywords[3].score | 0.4492727816104889 |
| keywords[3].display_name | Polycaprolactone |
| keywords[4].id | https://openalex.org/keywords/3d-printed |
| keywords[4].score | 0.4428703784942627 |
| keywords[4].display_name | 3d printed |
| keywords[5].id | https://openalex.org/keywords/mechanobiology |
| keywords[5].score | 0.44099509716033936 |
| keywords[5].display_name | Mechanobiology |
| keywords[6].id | https://openalex.org/keywords/composite-material |
| keywords[6].score | 0.3176083564758301 |
| keywords[6].display_name | Composite material |
| keywords[7].id | https://openalex.org/keywords/anatomy |
| keywords[7].score | 0.14592519402503967 |
| keywords[7].display_name | Anatomy |
| keywords[8].id | https://openalex.org/keywords/engineering |
| keywords[8].score | 0.10755467414855957 |
| keywords[8].display_name | Engineering |
| language | en |
| locations[0].id | doi:10.1186/s41205-025-00278-7 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210191256 |
| locations[0].source.issn | 2365-6271 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2365-6271 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | 3D Printing in Medicine |
| locations[0].source.host_organization | https://openalex.org/P4310320256 |
| locations[0].source.host_organization_name | BioMed Central |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | BioMed Central, Springer Nature |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | 3D Printing in Medicine |
| locations[0].landing_page_url | https://doi.org/10.1186/s41205-025-00278-7 |
| locations[1].id | pmid:40536605 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | 3D printing in medicine |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40536605 |
| locations[2].id | pmh:oai:doaj.org/article:9044e39b3c5b4f0fb6cfeb1b23b1d3a7 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | 3D Printing in Medicine, Vol 11, Iss 1, Pp 1-18 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/9044e39b3c5b4f0fb6cfeb1b23b1d3a7 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:12177956 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | 3D Print Med |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12177956 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5064336211 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Hsuan Chih Liu |
| authorships[0].countries | TW |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210136334 |
| authorships[0].affiliations[1].raw_affiliation_string | Chi-mei Medical Center, Department of Orthopedic, Liouying, Tainan, Taiwan. |
| authorships[0].institutions[0].id | https://openalex.org/I4210136334 |
| authorships[0].institutions[0].ror | https://ror.org/02y2htg06 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210136334 |
| authorships[0].institutions[0].country_code | TW |
| authorships[0].institutions[0].display_name | Chi Mei Medical Center |
| authorships[0].institutions[1].id | https://openalex.org/I148366613 |
| authorships[0].institutions[1].ror | https://ror.org/00se2k293 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I148366613 |
| authorships[0].institutions[1].country_code | TW |
| authorships[0].institutions[1].display_name | National Yang Ming Chiao Tung University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hsuan Chih Liu |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Chi-mei Medical Center, Department of Orthopedic, Liouying, Tainan, Taiwan., Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[1].author.id | https://openalex.org/A5053588103 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Ya-Han Chan |
| authorships[1].countries | TW |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[1].institutions[0].id | https://openalex.org/I148366613 |
| authorships[1].institutions[0].ror | https://ror.org/00se2k293 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I148366613 |
| authorships[1].institutions[0].country_code | TW |
| authorships[1].institutions[0].display_name | National Yang Ming Chiao Tung University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Ya-Han Chan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[2].author.id | https://openalex.org/A5102379509 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Shao-Fu Huang |
| authorships[2].countries | TW |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I148366613 |
| authorships[2].affiliations[1].raw_affiliation_string | Medical Device Innovation & Translation Center, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. |
| authorships[2].institutions[0].id | https://openalex.org/I148366613 |
| authorships[2].institutions[0].ror | https://ror.org/00se2k293 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I148366613 |
| authorships[2].institutions[0].country_code | TW |
| authorships[2].institutions[0].display_name | National Yang Ming Chiao Tung University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shao-Fu Huang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan., Medical Device Innovation & Translation Center, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. |
| authorships[3].author.id | https://openalex.org/A5027861907 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0066-4822 |
| authorships[3].author.display_name | Wei‐Che Tsai |
| authorships[3].countries | TW |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[3].institutions[0].id | https://openalex.org/I148366613 |
| authorships[3].institutions[0].ror | https://ror.org/00se2k293 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I148366613 |
| authorships[3].institutions[0].country_code | TW |
| authorships[3].institutions[0].display_name | National Yang Ming Chiao Tung University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Wei-Che Tsai |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[4].author.id | https://openalex.org/A5101834213 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-1191-8979 |
| authorships[4].author.display_name | Yu‐Ting Cheng |
| authorships[4].countries | TW |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[4].institutions[0].id | https://openalex.org/I148366613 |
| authorships[4].institutions[0].ror | https://ror.org/00se2k293 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I148366613 |
| authorships[4].institutions[0].country_code | TW |
| authorships[4].institutions[0].display_name | National Yang Ming Chiao Tung University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yen Cheng |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. |
| authorships[5].author.id | https://openalex.org/A5084944154 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-5958-0949 |
| authorships[5].author.display_name | Chun‐Li Lin |
| authorships[5].countries | TW |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I148366613 |
| authorships[5].affiliations[0].raw_affiliation_string | Medical Device Innovation & Translation Center, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. [email protected]. |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I148366613 |
| authorships[5].affiliations[1].raw_affiliation_string | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. [email protected]. |
| authorships[5].institutions[0].id | https://openalex.org/I148366613 |
| authorships[5].institutions[0].ror | https://ror.org/00se2k293 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I148366613 |
| authorships[5].institutions[0].country_code | TW |
| authorships[5].institutions[0].display_name | National Yang Ming Chiao Tung University |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Chun-Li Lin |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Biomedical Engineering, National Yang Ming Chaio Tung University, Hsinchu, Taiwan. [email protected]., Medical Device Innovation & Translation Center, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. [email protected]. |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Early stage prediction of bone regeneration using FEA and cell differentiation algorithms with 3D-printed PLA and PCL scaffolds: modeling and application to dorsal double-plating in distal radius fractures |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10658 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9991999864578247 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Bone fractures and treatments |
| related_works | https://openalex.org/W2607564050, https://openalex.org/W2028483600, https://openalex.org/W4408812430, https://openalex.org/W2774256619, https://openalex.org/W2806900799, https://openalex.org/W4390094986, https://openalex.org/W2096303359, https://openalex.org/W4321350921, https://openalex.org/W4400135105, https://openalex.org/W2010343663 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.1186/s41205-025-00278-7 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210191256 |
| best_oa_location.source.issn | 2365-6271 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2365-6271 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | 3D Printing in Medicine |
| best_oa_location.source.host_organization | https://openalex.org/P4310320256 |
| best_oa_location.source.host_organization_name | BioMed Central |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | 3D Printing in Medicine |
| best_oa_location.landing_page_url | https://doi.org/10.1186/s41205-025-00278-7 |
| primary_location.id | doi:10.1186/s41205-025-00278-7 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210191256 |
| primary_location.source.issn | 2365-6271 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2365-6271 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | 3D Printing in Medicine |
| primary_location.source.host_organization | https://openalex.org/P4310320256 |
| primary_location.source.host_organization_name | BioMed Central |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320256, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | BioMed Central, Springer Nature |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://threedmedprint.biomedcentral.com/counter/pdf/10.1186/s41205-025-00278-7 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | 3D Printing in Medicine |
| primary_location.landing_page_url | https://doi.org/10.1186/s41205-025-00278-7 |
| publication_date | 2025-06-19 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W3007142388, https://openalex.org/W4212896185, https://openalex.org/W4390365984, https://openalex.org/W4394962288, https://openalex.org/W4380686527, https://openalex.org/W4390701455, https://openalex.org/W2164743243, https://openalex.org/W4391169825, https://openalex.org/W3179476493, https://openalex.org/W4394787267, https://openalex.org/W1984589322, https://openalex.org/W2041911911, https://openalex.org/W2055453264, https://openalex.org/W2030214519, https://openalex.org/W2051427047, https://openalex.org/W1965696823, https://openalex.org/W4285729461, https://openalex.org/W2010751506, https://openalex.org/W1970237590, https://openalex.org/W1857671168, https://openalex.org/W2055643182, https://openalex.org/W4321201826, https://openalex.org/W3009777271, https://openalex.org/W2461747263, https://openalex.org/W4293173760, https://openalex.org/W2132323306, https://openalex.org/W1986714312, https://openalex.org/W2046199669, https://openalex.org/W4391825136, https://openalex.org/W2035966549, https://openalex.org/W1964341838, https://openalex.org/W2071145526, https://openalex.org/W2122770196, https://openalex.org/W4403401952, https://openalex.org/W4323275841, https://openalex.org/W2807165335, https://openalex.org/W4403530958, https://openalex.org/W4313293426, https://openalex.org/W2586338151 |
| referenced_works_count | 39 |
| abstract_inverted_index.+ | 174, 199 |
| abstract_inverted_index.a | 37, 79, 165, 221 |
| abstract_inverted_index.36 | 127 |
| abstract_inverted_index.50 | 161 |
| abstract_inverted_index.DU | 112, 175 |
| abstract_inverted_index.YM | 200 |
| abstract_inverted_index.an | 3 |
| abstract_inverted_index.as | 148 |
| abstract_inverted_index.by | 179, 183, 189 |
| abstract_inverted_index.in | 164, 212, 229 |
| abstract_inverted_index.mm | 167 |
| abstract_inverted_index.of | 26, 111, 130, 141, 208 |
| abstract_inverted_index.on | 61 |
| abstract_inverted_index.to | 22, 52, 78, 126, 196 |
| abstract_inverted_index.5.4 | 166 |
| abstract_inverted_index.PCL | 100, 198 |
| abstract_inverted_index.PLA | 93, 153, 173 |
| abstract_inverted_index.The | 34, 58, 121 |
| abstract_inverted_index.and | 19, 48, 65, 72, 97, 118, 134, 185, 217 |
| abstract_inverted_index.for | 30, 44, 85, 224 |
| abstract_inverted_index.gap | 169 |
| abstract_inverted_index.key | 150 |
| abstract_inverted_index.the | 24, 108, 138, 149, 172, 197, 205 |
| abstract_inverted_index.(DU) | 71 |
| abstract_inverted_index.(FE) | 17 |
| abstract_inverted_index.(S), | 42 |
| abstract_inverted_index.(YM) | 74 |
| abstract_inverted_index.TPCD | 156 |
| abstract_inverted_index.This | 0, 202 |
| abstract_inverted_index.acid | 63 |
| abstract_inverted_index.bone | 11, 31, 55, 122, 181, 226 |
| abstract_inverted_index.cell | 9, 39, 56, 142 |
| abstract_inverted_index.role | 207 |
| abstract_inverted_index.that | 6, 92, 171 |
| abstract_inverted_index.with | 14, 69, 152 |
| abstract_inverted_index.(DDP) | 82 |
| abstract_inverted_index.(PCL) | 67 |
| abstract_inverted_index.(PLA) | 64 |
| abstract_inverted_index.after | 160 |
| abstract_inverted_index.gaps, | 132 |
| abstract_inverted_index.model | 84, 128 |
| abstract_inverted_index.plate | 187 |
| abstract_inverted_index.shear | 46, 50 |
| abstract_inverted_index.shows | 170 |
| abstract_inverted_index.study | 1, 59, 203 |
| abstract_inverted_index.tests | 106 |
| abstract_inverted_index.total | 139 |
| abstract_inverted_index.under | 115, 191 |
| abstract_inverted_index.while | 99 |
| abstract_inverted_index.defect | 32 |
| abstract_inverted_index.distal | 86 |
| abstract_inverted_index.dorsal | 80 |
| abstract_inverted_index.finite | 15 |
| abstract_inverted_index.higher | 95 |
| abstract_inverted_index.loads, | 193 |
| abstract_inverted_index.offers | 101 |
| abstract_inverted_index.radius | 87 |
| abstract_inverted_index.random | 73 |
| abstract_inverted_index.repair | 227 |
| abstract_inverted_index.robust | 222 |
| abstract_inverted_index.shear, | 117 |
| abstract_inverted_index.stress | 47, 182, 188 |
| abstract_inverted_index.theory | 13 |
| abstract_inverted_index.(TPCD), | 144 |
| abstract_inverted_index.applied | 77, 125 |
| abstract_inverted_index.confirm | 107 |
| abstract_inverted_index.diamond | 70 |
| abstract_inverted_index.dynamic | 209 |
| abstract_inverted_index.element | 16 |
| abstract_inverted_index.factor, | 151 |
| abstract_inverted_index.focuses | 60 |
| abstract_inverted_index.forces. | 120 |
| abstract_inverted_index.lattice | 75, 113, 135, 218 |
| abstract_inverted_index.predict | 54 |
| abstract_inverted_index.program | 35 |
| abstract_inverted_index.reduces | 177 |
| abstract_inverted_index.repair. | 33 |
| abstract_inverted_index.reveals | 91 |
| abstract_inverted_index.strain, | 51 |
| abstract_inverted_index.testing | 90 |
| abstract_inverted_index.torsion | 119 |
| abstract_inverted_index.values. | 157 |
| abstract_inverted_index.Material | 89 |
| abstract_inverted_index.advanced | 4 |
| abstract_inverted_index.analysis | 18, 159 |
| abstract_inverted_index.biphasic | 8 |
| abstract_inverted_index.compared | 195 |
| abstract_inverted_index.computes | 137 |
| abstract_inverted_index.critical | 206 |
| abstract_inverted_index.designs, | 76, 136 |
| abstract_inverted_index.evaluate | 23 |
| abstract_inverted_index.fixation | 83, 186 |
| abstract_inverted_index.fracture | 131, 168 |
| abstract_inverted_index.material | 147, 215 |
| abstract_inverted_index.platform | 223 |
| abstract_inverted_index.program, | 124 |
| abstract_inverted_index.programs | 211 |
| abstract_inverted_index.provides | 94 |
| abstract_inverted_index.rigidity | 96 |
| abstract_inverted_index.scaffold | 146, 176, 214 |
| abstract_inverted_index.stimulus | 41 |
| abstract_inverted_index.strength | 105 |
| abstract_inverted_index.superior | 102, 109 |
| abstract_inverted_index.behavior. | 57 |
| abstract_inverted_index.enhancing | 155 |
| abstract_inverted_index.framework | 5 |
| abstract_inverted_index.medicine. | 231 |
| abstract_inverted_index.scaffold. | 201 |
| abstract_inverted_index.scaffolds | 29, 68 |
| abstract_inverted_index.solutions | 228 |
| abstract_inverted_index.strength, | 98 |
| abstract_inverted_index.3D-printed | 27 |
| abstract_inverted_index.Mechanical | 104 |
| abstract_inverted_index.accounting | 43 |
| abstract_inverted_index.ductility. | 103 |
| abstract_inverted_index.fractures. | 88 |
| abstract_inverted_index.highlights | 204 |
| abstract_inverted_index.integrates | 7 |
| abstract_inverted_index.introduces | 2 |
| abstract_inverted_index.iterations | 163 |
| abstract_inverted_index.materials, | 133 |
| abstract_inverted_index.optimizing | 213 |
| abstract_inverted_index.percentage | 140 |
| abstract_inverted_index.polylactic | 62 |
| abstract_inverted_index.properties | 216 |
| abstract_inverted_index.remodeling | 12, 123, 162, 210 |
| abstract_inverted_index.simulation | 21 |
| abstract_inverted_index.structures | 114 |
| abstract_inverted_index.77%/66%/93% | 190 |
| abstract_inverted_index.dynamically | 53 |
| abstract_inverted_index.fluid-phase | 45 |
| abstract_inverted_index.identifying | 145 |
| abstract_inverted_index.performance | 25, 110 |
| abstract_inverted_index.solid-phase | 49 |
| abstract_inverted_index.19%/16%/67%, | 184 |
| abstract_inverted_index.35%/39%/75%, | 180 |
| abstract_inverted_index.combinations | 129 |
| abstract_inverted_index.compression, | 116 |
| abstract_inverted_index.displacement | 178 |
| abstract_inverted_index.establishing | 220 |
| abstract_inverted_index.incorporates | 36 |
| abstract_inverted_index.regenerative | 230 |
| abstract_inverted_index.Biomechanical | 158 |
| abstract_inverted_index.biodegradable | 28 |
| abstract_inverted_index.respectively, | 194 |
| abstract_inverted_index.significantly | 154 |
| abstract_inverted_index.architectures, | 219 |
| abstract_inverted_index.double-plating | 81 |
| abstract_inverted_index.time-dependent | 38 |
| abstract_inverted_index.differentiation | 10, 40, 143 |
| abstract_inverted_index.multi-remodeling | 20 |
| abstract_inverted_index.patient-specific | 225 |
| abstract_inverted_index.polycaprolactone | 66 |
| abstract_inverted_index.axial/bending/torsion | 192 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.4300000071525574 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.88212173 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |