Early vvECMO implantation may be associated with lower mortality in ARDS Article Swipe
Peter Rosenberger
,
Lisa Korell
,
Helene A. Haeberle
,
Valbona Mirakaj
,
Alice Bernard
,
Linyan Tang
,
Andreas Körner
,
Peter Martus
,
Michael Koeppen
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12931-023-02541-z
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12931-023-02541-z
Background Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timing of initiation of vvECMO therapy. We aimed to investigate the association between number of days of invasive mechanical ventilation (IMV) prior to vvECMO implantation and mortality. Methods In this retrospective observational study, we included patients treated at an academic intensive care unit with vvECMO for severe ARDS. The primary outcome was all-cause 28-day mortality. We conducted a multivariate logistic regression analysis to estimate the association between number of days of IMV prior to vvECMO implantation and mortality after adjustment for confounders. Results Out of 274 patients who underwent ECMO for severe ARDS, 158 patients (median age: 58 years) with relevant data were included in the analysis. The mean duration of IMV prior to vvECMO was significantly shorter in survivors than in nonsurvivors [survivors median: 1; interquartile range: 1–3; non-survivors median 4; interquartile range: 1–5.75; p = 0.0001). Logistic regression showed an association between the duration of ventilation prior to vvECMO and patient mortality. The odds ratio for the all-cause 28-day mortality and in-hospital mortality was significantly reduced in patients who received vvECMO within the first 5 days of IMV. Conclusions Early vvECMO implantation may be associated with lower mortality in ARDS.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12931-023-02541-z
- https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02541-z
- OA Status
- gold
- Cited By
- 6
- References
- 21
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387051798
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4387051798Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s12931-023-02541-zDigital Object Identifier
- Title
-
Early vvECMO implantation may be associated with lower mortality in ARDSWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-26Full publication date if available
- Authors
-
Peter Rosenberger, Lisa Korell, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Linyan Tang, Andreas Körner, Peter Martus, Michael KoeppenList of authors in order
- Landing page
-
https://doi.org/10.1186/s12931-023-02541-zPublisher landing page
- PDF URL
-
https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02541-zDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
-
https://respiratory-research.biomedcentral.com/counter/pdf/10.1186/s12931-023-02541-zDirect OA link when available
- Concepts
-
ARDS, Interquartile range, Medicine, Extracorporeal membrane oxygenation, Mechanical ventilation, Odds ratio, Logistic regression, Intensive care unit, Retrospective cohort study, Internal medicine, Confounding, Mortality rate, LungTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 4Per-year citation counts (last 5 years)
- References (count)
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21Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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