Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24 Article Swipe
Palaniappan Ramanathan
,
Bersabeh Tigabu
,
Rodrigo I. Santos
,
Philipp A. Ilinykh
,
Natalia A. Kuzmina
,
O. A. Vogel
,
Naveen Thakur
,
Hamza Ahmed
,
Chao Wu
,
Gaya K. Amarasinghe
,
Christopher F. Basler
,
Alexander Bukreyev
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/v15051075
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/v15051075
Members of the Ebolavirus genus demonstrate a marked differences in pathogenicity in humans with Ebola (EBOV) being the most pathogenic, Bundibugyo (BDBV) less pathogenic, and Reston (RESTV) is not known to cause a disease in humans. The VP24 protein encoded by members of the Ebolavirus genus blocks type I interferon (IFN-I) signaling through interaction with host karyopherin alpha nuclear transporters, potentially contributing to virulence. Previously, we demonstrated that BDBV VP24 (bVP24) binds with lower affinities to karyopherin alpha proteins relative to EBOV VP24 (eVP24), and this correlated with a reduced inhibition in IFN-I signaling. We hypothesized that modification of eVP24-karyopherin alpha interface to make it similar to bVP24 would attenuate the ability to antagonize IFN-I response. We generated a panel of recombinant EBOVs containing single or combinations of point mutations in the eVP24-karyopherin alpha interface. Most of the viruses appeared to be attenuated in both IFN-I-competent 769-P and IFN-I-deficient Vero-E6 cells in the presence of IFNs. However, the R140A mutant grew at reduced levels even in the absence of IFNs in both cell lines, as well as in U3A STAT1 knockout cells. Both the R140A mutation and its combination with the N135A mutation greatly reduced the amounts of viral genomic RNA and mRNA suggesting that these mutations attenuate the virus in an IFN-I-independent attenuation. Additionally, we found that unlike eVP24, bVP24 does not inhibit interferon lambda 1 (IFN-λ1), interferon beta (IFN-β), and ISG15, which potentially explains the lower pathogenicity of BDBV relative to EBOV. Thus, the VP24 residues binding karyopherin alpha attenuates the virus by IFN-I-dependent and independent mechanisms.
Related Topics
Concepts
Ebolavirus
Karyopherin
Biology
Interferon
Virology
Interferon-stimulated gene
Ebola virus
Alpha interferon
Vero cell
Virus
Genetics
Gene
Nuclear transport
Receptor
Cell nucleus
Innate immune system
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v15051075
- https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254
- OA Status
- gold
- Cited By
- 4
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367315839
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4367315839Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v15051075Digital Object Identifier
- Title
-
Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-28Full publication date if available
- Authors
-
Palaniappan Ramanathan, Bersabeh Tigabu, Rodrigo I. Santos, Philipp A. Ilinykh, Natalia A. Kuzmina, O. A. Vogel, Naveen Thakur, Hamza Ahmed, Chao Wu, Gaya K. Amarasinghe, Christopher F. Basler, Alexander BukreyevList of authors in order
- Landing page
-
https://doi.org/10.3390/v15051075Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254Direct OA link when available
- Concepts
-
Ebolavirus, Karyopherin, Biology, Interferon, Virology, Interferon-stimulated gene, Ebola virus, Alpha interferon, Vero cell, Virus, Genetics, Gene, Nuclear transport, Receptor, Cell nucleus, Innate immune systemTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2024: 3, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
49Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4367315839 |
|---|---|
| doi | https://doi.org/10.3390/v15051075 |
| ids.doi | https://doi.org/10.3390/v15051075 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/37243162 |
| ids.openalex | https://openalex.org/W4367315839 |
| fwci | 1.12669863 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D007372 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Interferons |
| mesh[2].qualifier_ui | Q000502 |
| mesh[2].descriptor_ui | D029043 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | physiology |
| mesh[2].descriptor_name | Ebolavirus |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D028901 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | alpha Karyopherins |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D028901 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | alpha Karyopherins |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D014764 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Viral Proteins |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D016899 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | Interferon-beta |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D016899 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | Interferon-beta |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D019142 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006801 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Humans |
| mesh[10].qualifier_ui | Q000378 |
| mesh[10].descriptor_ui | D007372 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | metabolism |
| mesh[10].descriptor_name | Interferons |
| mesh[11].qualifier_ui | Q000502 |
| mesh[11].descriptor_ui | D029043 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | physiology |
| mesh[11].descriptor_name | Ebolavirus |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D028901 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | alpha Karyopherins |
| mesh[13].qualifier_ui | Q000378 |
| mesh[13].descriptor_ui | D028901 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | metabolism |
| mesh[13].descriptor_name | alpha Karyopherins |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D014764 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Viral Proteins |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D016899 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Interferon-beta |
| mesh[16].qualifier_ui | Q000378 |
| mesh[16].descriptor_ui | D016899 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | metabolism |
| mesh[16].descriptor_name | Interferon-beta |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D019142 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D006801 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Humans |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D007372 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Interferons |
| mesh[20].qualifier_ui | Q000502 |
| mesh[20].descriptor_ui | D029043 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | physiology |
| mesh[20].descriptor_name | Ebolavirus |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D028901 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | alpha Karyopherins |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D028901 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | alpha Karyopherins |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D014764 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Viral Proteins |
| mesh[24].qualifier_ui | Q000235 |
| mesh[24].descriptor_ui | D016899 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | genetics |
| mesh[24].descriptor_name | Interferon-beta |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D016899 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Interferon-beta |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D019142 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Hemorrhagic Fever, Ebola |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D006801 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Humans |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D007372 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Interferons |
| mesh[29].qualifier_ui | Q000502 |
| mesh[29].descriptor_ui | D029043 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | physiology |
| mesh[29].descriptor_name | Ebolavirus |
| mesh[30].qualifier_ui | Q000235 |
| mesh[30].descriptor_ui | D028901 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | genetics |
| mesh[30].descriptor_name | alpha Karyopherins |
| mesh[31].qualifier_ui | Q000378 |
| mesh[31].descriptor_ui | D028901 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | metabolism |
| mesh[31].descriptor_name | alpha Karyopherins |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D014764 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | Viral Proteins |
| mesh[33].qualifier_ui | Q000235 |
| mesh[33].descriptor_ui | D016899 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | genetics |
| mesh[33].descriptor_name | Interferon-beta |
| mesh[34].qualifier_ui | Q000378 |
| mesh[34].descriptor_ui | D016899 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | metabolism |
| mesh[34].descriptor_name | Interferon-beta |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D019142 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Hemorrhagic Fever, Ebola |
| type | article |
| title | Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24 |
| awards[0].id | https://openalex.org/G967380284 |
| awards[0].funder_id | https://openalex.org/F4320332505 |
| awards[0].display_name | |
| awards[0].funder_award_id | AI07647 |
| awards[0].funder_display_name | U.S. Public Health Service |
| awards[1].id | https://openalex.org/G7273833945 |
| awards[1].funder_id | https://openalex.org/F4320332161 |
| awards[1].display_name | |
| awards[1].funder_award_id | R01AI148663 |
| awards[1].funder_display_name | National Institutes of Health |
| awards[2].id | https://openalex.org/G7989655894 |
| awards[2].funder_id | https://openalex.org/F4320332161 |
| awards[2].display_name | |
| awards[2].funder_award_id | R01AI161374 |
| awards[2].funder_display_name | National Institutes of Health |
| awards[3].id | https://openalex.org/G8145548034 |
| awards[3].funder_id | https://openalex.org/F4320332161 |
| awards[3].display_name | |
| awards[3].funder_award_id | R01AI143292 |
| awards[3].funder_display_name | National Institutes of Health |
| awards[4].id | https://openalex.org/G4032983048 |
| awards[4].funder_id | https://openalex.org/F4320332161 |
| awards[4].display_name | |
| awards[4].funder_award_id | R01AI123926 |
| awards[4].funder_display_name | National Institutes of Health |
| awards[5].id | https://openalex.org/G4256575359 |
| awards[5].funder_id | https://openalex.org/F4320332161 |
| awards[5].display_name | |
| awards[5].funder_award_id | AI109664 |
| awards[5].funder_display_name | National Institutes of Health |
| awards[6].id | https://openalex.org/G3522468722 |
| awards[6].funder_id | https://openalex.org/F4320332161 |
| awards[6].display_name | |
| awards[6].funder_award_id | P01AI120943 |
| awards[6].funder_display_name | National Institutes of Health |
| biblio.issue | 5 |
| biblio.volume | 15 |
| biblio.last_page | 1075 |
| biblio.first_page | 1075 |
| topics[0].id | https://openalex.org/T11581 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2725 |
| topics[0].subfield.display_name | Infectious Diseases |
| topics[0].display_name | Viral Infections and Outbreaks Research |
| topics[1].id | https://openalex.org/T12047 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9983000159263611 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | Viral Infections and Vectors |
| topics[2].id | https://openalex.org/T11668 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9886000156402588 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | interferon and immune responses |
| funders[0].id | https://openalex.org/F4320332161 |
| funders[0].ror | https://ror.org/01cwqze88 |
| funders[0].display_name | National Institutes of Health |
| funders[1].id | https://openalex.org/F4320332505 |
| funders[1].ror | https://ror.org/05xf94514 |
| funders[1].display_name | U.S. Public Health Service |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2815 |
| concepts[0].id | https://openalex.org/C2909623084 |
| concepts[0].level | 4 |
| concepts[0].score | 0.8536285161972046 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q5331908 |
| concepts[0].display_name | Ebolavirus |
| concepts[1].id | https://openalex.org/C2777336224 |
| concepts[1].level | 5 |
| concepts[1].score | 0.8086791038513184 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q3193641 |
| concepts[1].display_name | Karyopherin |
| concepts[2].id | https://openalex.org/C86803240 |
| concepts[2].level | 0 |
| concepts[2].score | 0.7587051391601562 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[2].display_name | Biology |
| concepts[3].id | https://openalex.org/C2776178377 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6290907859802246 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q188269 |
| concepts[3].display_name | Interferon |
| concepts[4].id | https://openalex.org/C159047783 |
| concepts[4].level | 1 |
| concepts[4].score | 0.626534640789032 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[4].display_name | Virology |
| concepts[5].id | https://openalex.org/C2777668594 |
| concepts[5].level | 4 |
| concepts[5].score | 0.48344239592552185 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q19597598 |
| concepts[5].display_name | Interferon-stimulated gene |
| concepts[6].id | https://openalex.org/C2777469322 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4790585935115814 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q8064876 |
| concepts[6].display_name | Ebola virus |
| concepts[7].id | https://openalex.org/C2909179924 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4692509174346924 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q6046488 |
| concepts[7].display_name | Alpha interferon |
| concepts[8].id | https://openalex.org/C89138240 |
| concepts[8].level | 3 |
| concepts[8].score | 0.41526609659194946 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3066564 |
| concepts[8].display_name | Vero cell |
| concepts[9].id | https://openalex.org/C2522874641 |
| concepts[9].level | 2 |
| concepts[9].score | 0.2888174057006836 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[9].display_name | Virus |
| concepts[10].id | https://openalex.org/C54355233 |
| concepts[10].level | 1 |
| concepts[10].score | 0.24568119645118713 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[10].display_name | Genetics |
| concepts[11].id | https://openalex.org/C104317684 |
| concepts[11].level | 2 |
| concepts[11].score | 0.15104293823242188 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[11].display_name | Gene |
| concepts[12].id | https://openalex.org/C59157529 |
| concepts[12].level | 4 |
| concepts[12].score | 0.14673644304275513 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q994741 |
| concepts[12].display_name | Nuclear transport |
| concepts[13].id | https://openalex.org/C170493617 |
| concepts[13].level | 2 |
| concepts[13].score | 0.08067753911018372 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q208467 |
| concepts[13].display_name | Receptor |
| concepts[14].id | https://openalex.org/C2780114586 |
| concepts[14].level | 3 |
| concepts[14].score | 0.0627787709236145 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q40260 |
| concepts[14].display_name | Cell nucleus |
| concepts[15].id | https://openalex.org/C136449434 |
| concepts[15].level | 3 |
| concepts[15].score | 0.0 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q428253 |
| concepts[15].display_name | Innate immune system |
| keywords[0].id | https://openalex.org/keywords/ebolavirus |
| keywords[0].score | 0.8536285161972046 |
| keywords[0].display_name | Ebolavirus |
| keywords[1].id | https://openalex.org/keywords/karyopherin |
| keywords[1].score | 0.8086791038513184 |
| keywords[1].display_name | Karyopherin |
| keywords[2].id | https://openalex.org/keywords/biology |
| keywords[2].score | 0.7587051391601562 |
| keywords[2].display_name | Biology |
| keywords[3].id | https://openalex.org/keywords/interferon |
| keywords[3].score | 0.6290907859802246 |
| keywords[3].display_name | Interferon |
| keywords[4].id | https://openalex.org/keywords/virology |
| keywords[4].score | 0.626534640789032 |
| keywords[4].display_name | Virology |
| keywords[5].id | https://openalex.org/keywords/interferon-stimulated-gene |
| keywords[5].score | 0.48344239592552185 |
| keywords[5].display_name | Interferon-stimulated gene |
| keywords[6].id | https://openalex.org/keywords/ebola-virus |
| keywords[6].score | 0.4790585935115814 |
| keywords[6].display_name | Ebola virus |
| keywords[7].id | https://openalex.org/keywords/alpha-interferon |
| keywords[7].score | 0.4692509174346924 |
| keywords[7].display_name | Alpha interferon |
| keywords[8].id | https://openalex.org/keywords/vero-cell |
| keywords[8].score | 0.41526609659194946 |
| keywords[8].display_name | Vero cell |
| keywords[9].id | https://openalex.org/keywords/virus |
| keywords[9].score | 0.2888174057006836 |
| keywords[9].display_name | Virus |
| keywords[10].id | https://openalex.org/keywords/genetics |
| keywords[10].score | 0.24568119645118713 |
| keywords[10].display_name | Genetics |
| keywords[11].id | https://openalex.org/keywords/gene |
| keywords[11].score | 0.15104293823242188 |
| keywords[11].display_name | Gene |
| keywords[12].id | https://openalex.org/keywords/nuclear-transport |
| keywords[12].score | 0.14673644304275513 |
| keywords[12].display_name | Nuclear transport |
| keywords[13].id | https://openalex.org/keywords/receptor |
| keywords[13].score | 0.08067753911018372 |
| keywords[13].display_name | Receptor |
| keywords[14].id | https://openalex.org/keywords/cell-nucleus |
| keywords[14].score | 0.0627787709236145 |
| keywords[14].display_name | Cell nucleus |
| language | en |
| locations[0].id | doi:10.3390/v15051075 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S55776271 |
| locations[0].source.issn | 1999-4915 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1999-4915 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Viruses |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Viruses |
| locations[0].landing_page_url | https://doi.org/10.3390/v15051075 |
| locations[1].id | pmid:37243162 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Viruses |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/37243162 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10222226 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10222226/pdf/viruses-15-01075.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Viruses |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10222226 |
| locations[3].id | pmh:oai:digitalcommons.wustl.edu:oa_4-2961 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400764 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Digital Commons@Becker (Washington University School of Medicine) |
| locations[3].source.host_organization | https://openalex.org/I204465549 |
| locations[3].source.host_organization_name | Washington University in St. Louis |
| locations[3].source.host_organization_lineage | https://openalex.org/I204465549 |
| locations[3].license | cc-by |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | text |
| locations[3].license_id | https://openalex.org/licenses/cc-by |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | 2020-Current year OA Pubs |
| locations[3].landing_page_url | https://digitalcommons.wustl.edu/oa_4/1970 |
| locations[4].id | pmh:oai:doaj.org/article:9daf9e18ecfc4868816c4867f5e79888 |
| locations[4].is_oa | False |
| locations[4].source.id | https://openalex.org/S4306401280 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[4].source.host_organization | |
| locations[4].source.host_organization_name | |
| locations[4].license | |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | article |
| locations[4].license_id | |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Viruses, Vol 15, Iss 5, p 1075 (2023) |
| locations[4].landing_page_url | https://doaj.org/article/9daf9e18ecfc4868816c4867f5e79888 |
| locations[5].id | pmh:oai:mdpi.com:/1999-4915/15/5/1075/ |
| locations[5].is_oa | True |
| locations[5].source.id | https://openalex.org/S4306400947 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | True |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | MDPI (MDPI AG) |
| locations[5].source.host_organization | https://openalex.org/I4210097602 |
| locations[5].source.host_organization_name | Multidisciplinary Digital Publishing Institute (Switzerland) |
| locations[5].source.host_organization_lineage | https://openalex.org/I4210097602 |
| locations[5].license | cc-by |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Text |
| locations[5].license_id | https://openalex.org/licenses/cc-by |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | Viruses; Volume 15; Issue 5; Pages: 1075 |
| locations[5].landing_page_url | https://dx.doi.org/10.3390/v15051075 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5103036463 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-8121-7647 |
| authorships[0].author.display_name | Palaniappan Ramanathan |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[0].affiliations[1].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[0].institutions[0].id | https://openalex.org/I55302922 |
| authorships[0].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Palaniappan Ramanathan |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[1].author.id | https://openalex.org/A5002490955 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Bersabeh Tigabu |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[1].affiliations[1].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[1].institutions[0].id | https://openalex.org/I55302922 |
| authorships[1].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Bersabeh Tigabu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[2].author.id | https://openalex.org/A5068651560 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-2548-1288 |
| authorships[2].author.display_name | Rodrigo I. Santos |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[2].affiliations[1].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[2].institutions[0].id | https://openalex.org/I55302922 |
| authorships[2].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Rodrigo I. Santos |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[3].author.id | https://openalex.org/A5034878859 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Philipp A. Ilinykh |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[3].affiliations[1].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[3].institutions[0].id | https://openalex.org/I55302922 |
| authorships[3].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Philipp A. Ilinykh |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[4].author.id | https://openalex.org/A5029705683 |
| authorships[4].author.orcid | https://orcid.org/0000-0001-6650-9369 |
| authorships[4].author.display_name | Natalia A. Kuzmina |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[4].affiliations[1].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[4].institutions[0].id | https://openalex.org/I55302922 |
| authorships[4].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Natalia Kuzmina |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[5].author.id | https://openalex.org/A5003736109 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-7918-0395 |
| authorships[5].author.display_name | O. A. Vogel |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[5].institutions[0].id | https://openalex.org/I98704320 |
| authorships[5].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Olivia A. Vogel |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[6].author.id | https://openalex.org/A5083908228 |
| authorships[6].author.orcid | https://orcid.org/0009-0008-9537-8423 |
| authorships[6].author.display_name | Naveen Thakur |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[6].institutions[0].id | https://openalex.org/I98704320 |
| authorships[6].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Naveen Thakur |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[7].author.id | https://openalex.org/A5003705552 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-5764-2299 |
| authorships[7].author.display_name | Hamza Ahmed |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I204465549 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[7].institutions[0].id | https://openalex.org/I204465549 |
| authorships[7].institutions[0].ror | https://ror.org/01yc7t268 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I204465549 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Washington University in St. Louis |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Hamza Ahmed |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[8].author.id | https://openalex.org/A5016330167 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-9342-1968 |
| authorships[8].author.display_name | Chao Wu |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I204465549 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[8].institutions[0].id | https://openalex.org/I204465549 |
| authorships[8].institutions[0].ror | https://ror.org/01yc7t268 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I204465549 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | Washington University in St. Louis |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Chao Wu |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[9].author.id | https://openalex.org/A5036377965 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0418-9707 |
| authorships[9].author.display_name | Gaya K. Amarasinghe |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I204465549 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[9].institutions[0].id | https://openalex.org/I204465549 |
| authorships[9].institutions[0].ror | https://ror.org/01yc7t268 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I204465549 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Washington University in St. Louis |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Gaya K. Amarasinghe |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA |
| authorships[10].author.id | https://openalex.org/A5054163903 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-4195-425X |
| authorships[10].author.display_name | Christopher F. Basler |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I98704320 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[10].institutions[0].id | https://openalex.org/I98704320 |
| authorships[10].institutions[0].ror | https://ror.org/04a9tmd77 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Christopher F. Basler |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA |
| authorships[11].author.id | https://openalex.org/A5015757298 |
| authorships[11].author.orcid | https://orcid.org/0000-0002-0342-4824 |
| authorships[11].author.display_name | Alexander Bukreyev |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I55302922 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Microbiology & Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I55302922 |
| authorships[11].affiliations[1].raw_affiliation_string | Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[11].affiliations[2].institution_ids | https://openalex.org/I55302922 |
| authorships[11].affiliations[2].raw_affiliation_string | Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| authorships[11].institutions[0].id | https://openalex.org/I55302922 |
| authorships[11].institutions[0].ror | https://ror.org/016tfm930 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I55302922 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | The University of Texas Medical Branch at Galveston |
| authorships[11].author_position | last |
| authorships[11].raw_author_name | Alexander Bukreyev |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Microbiology & Immunology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Department of Pathology, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA, Galveston National Laboratory, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Ebolavirus Species-Specific Interferon Antagonism Mediated by VP24 |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11581 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2725 |
| primary_topic.subfield.display_name | Infectious Diseases |
| primary_topic.display_name | Viral Infections and Outbreaks Research |
| related_works | https://openalex.org/W2625387716, https://openalex.org/W2051802868, https://openalex.org/W2056946199, https://openalex.org/W4200430107, https://openalex.org/W1491619488, https://openalex.org/W2016869562, https://openalex.org/W2579764090, https://openalex.org/W2588428923, https://openalex.org/W2968139870, https://openalex.org/W4367315839 |
| cited_by_count | 4 |
| counts_by_year[0].year | 2024 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2023 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 6 |
| best_oa_location.id | doi:10.3390/v15051075 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S55776271 |
| best_oa_location.source.issn | 1999-4915 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1999-4915 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Viruses |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Viruses |
| best_oa_location.landing_page_url | https://doi.org/10.3390/v15051075 |
| primary_location.id | doi:10.3390/v15051075 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S55776271 |
| primary_location.source.issn | 1999-4915 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1999-4915 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Viruses |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1999-4915/15/5/1075/pdf?version=1683274254 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Viruses |
| primary_location.landing_page_url | https://doi.org/10.3390/v15051075 |
| publication_date | 2023-04-28 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2888770709, https://openalex.org/W4211119126, https://openalex.org/W2941200405, https://openalex.org/W3138406050, https://openalex.org/W2238727653, https://openalex.org/W2036436901, https://openalex.org/W2099533608, https://openalex.org/W2100827617, https://openalex.org/W2155409207, https://openalex.org/W2105746066, https://openalex.org/W2136920638, https://openalex.org/W2143537575, https://openalex.org/W2059118814, https://openalex.org/W2155205118, https://openalex.org/W2094597469, https://openalex.org/W2106587802, https://openalex.org/W2137587180, https://openalex.org/W2161862450, https://openalex.org/W2974314275, https://openalex.org/W3178080697, https://openalex.org/W2078645984, https://openalex.org/W2571039582, https://openalex.org/W1986021037, https://openalex.org/W1981692189, https://openalex.org/W2070419747, https://openalex.org/W2121689791, https://openalex.org/W3199519713, https://openalex.org/W2156449570, https://openalex.org/W2996654049, https://openalex.org/W2107277218, https://openalex.org/W2112449136, https://openalex.org/W2029424710, https://openalex.org/W2150409982, https://openalex.org/W2159199924, https://openalex.org/W2309148697, https://openalex.org/W1985403315, https://openalex.org/W2138789026, https://openalex.org/W6740199948, https://openalex.org/W2622621976, https://openalex.org/W2625387716, https://openalex.org/W2063371303, https://openalex.org/W2305571463, https://openalex.org/W2605610699, https://openalex.org/W2155970168, https://openalex.org/W3007924864, https://openalex.org/W4205875722, https://openalex.org/W1964184380, https://openalex.org/W4207078085, https://openalex.org/W2726855275 |
| referenced_works_count | 49 |
| abstract_inverted_index.1 | 226 |
| abstract_inverted_index.I | 48 |
| abstract_inverted_index.a | 6, 32, 88, 118 |
| abstract_inverted_index.We | 94, 116 |
| abstract_inverted_index.an | 211 |
| abstract_inverted_index.as | 174, 176 |
| abstract_inverted_index.at | 161 |
| abstract_inverted_index.be | 141 |
| abstract_inverted_index.by | 40, 254 |
| abstract_inverted_index.in | 9, 11, 34, 91, 130, 143, 151, 165, 170, 177, 210 |
| abstract_inverted_index.is | 27 |
| abstract_inverted_index.it | 104 |
| abstract_inverted_index.of | 1, 42, 98, 120, 127, 136, 154, 168, 197, 239 |
| abstract_inverted_index.or | 125 |
| abstract_inverted_index.to | 30, 62, 75, 80, 102, 106, 112, 140, 242 |
| abstract_inverted_index.we | 65, 215 |
| abstract_inverted_index.RNA | 200 |
| abstract_inverted_index.The | 36 |
| abstract_inverted_index.U3A | 178 |
| abstract_inverted_index.and | 24, 84, 147, 186, 201, 231, 256 |
| abstract_inverted_index.its | 187 |
| abstract_inverted_index.not | 28, 222 |
| abstract_inverted_index.the | 2, 17, 43, 110, 131, 137, 152, 157, 166, 183, 190, 195, 208, 236, 245, 252 |
| abstract_inverted_index.BDBV | 68, 240 |
| abstract_inverted_index.Both | 182 |
| abstract_inverted_index.EBOV | 81 |
| abstract_inverted_index.IFNs | 169 |
| abstract_inverted_index.Most | 135 |
| abstract_inverted_index.VP24 | 37, 69, 82, 246 |
| abstract_inverted_index.beta | 229 |
| abstract_inverted_index.both | 144, 171 |
| abstract_inverted_index.cell | 172 |
| abstract_inverted_index.does | 221 |
| abstract_inverted_index.even | 164 |
| abstract_inverted_index.grew | 160 |
| abstract_inverted_index.host | 55 |
| abstract_inverted_index.less | 22 |
| abstract_inverted_index.mRNA | 202 |
| abstract_inverted_index.make | 103 |
| abstract_inverted_index.most | 18 |
| abstract_inverted_index.that | 67, 96, 204, 217 |
| abstract_inverted_index.this | 85 |
| abstract_inverted_index.type | 47 |
| abstract_inverted_index.well | 175 |
| abstract_inverted_index.with | 13, 54, 72, 87, 189 |
| abstract_inverted_index.769-P | 146 |
| abstract_inverted_index.EBOV. | 243 |
| abstract_inverted_index.EBOVs | 122 |
| abstract_inverted_index.Ebola | 14 |
| abstract_inverted_index.IFN-I | 92, 114 |
| abstract_inverted_index.IFNs. | 155 |
| abstract_inverted_index.N135A | 191 |
| abstract_inverted_index.R140A | 158, 184 |
| abstract_inverted_index.STAT1 | 179 |
| abstract_inverted_index.Thus, | 244 |
| abstract_inverted_index.alpha | 57, 77, 100, 133, 250 |
| abstract_inverted_index.bVP24 | 107, 220 |
| abstract_inverted_index.being | 16 |
| abstract_inverted_index.binds | 71 |
| abstract_inverted_index.cause | 31 |
| abstract_inverted_index.cells | 150 |
| abstract_inverted_index.found | 216 |
| abstract_inverted_index.genus | 4, 45 |
| abstract_inverted_index.known | 29 |
| abstract_inverted_index.lower | 73, 237 |
| abstract_inverted_index.panel | 119 |
| abstract_inverted_index.point | 128 |
| abstract_inverted_index.these | 205 |
| abstract_inverted_index.viral | 198 |
| abstract_inverted_index.virus | 209, 253 |
| abstract_inverted_index.which | 233 |
| abstract_inverted_index.would | 108 |
| abstract_inverted_index.(BDBV) | 21 |
| abstract_inverted_index.(EBOV) | 15 |
| abstract_inverted_index.ISG15, | 232 |
| abstract_inverted_index.Reston | 25 |
| abstract_inverted_index.blocks | 46 |
| abstract_inverted_index.cells. | 181 |
| abstract_inverted_index.eVP24, | 219 |
| abstract_inverted_index.humans | 12 |
| abstract_inverted_index.lambda | 225 |
| abstract_inverted_index.levels | 163 |
| abstract_inverted_index.lines, | 173 |
| abstract_inverted_index.marked | 7 |
| abstract_inverted_index.mutant | 159 |
| abstract_inverted_index.single | 124 |
| abstract_inverted_index.unlike | 218 |
| abstract_inverted_index.(IFN-I) | 50 |
| abstract_inverted_index.(RESTV) | 26 |
| abstract_inverted_index.(bVP24) | 70 |
| abstract_inverted_index.Members | 0 |
| abstract_inverted_index.Vero-E6 | 149 |
| abstract_inverted_index.ability | 111 |
| abstract_inverted_index.absence | 167 |
| abstract_inverted_index.amounts | 196 |
| abstract_inverted_index.binding | 248 |
| abstract_inverted_index.disease | 33 |
| abstract_inverted_index.encoded | 39 |
| abstract_inverted_index.genomic | 199 |
| abstract_inverted_index.greatly | 193 |
| abstract_inverted_index.humans. | 35 |
| abstract_inverted_index.inhibit | 223 |
| abstract_inverted_index.members | 41 |
| abstract_inverted_index.nuclear | 58 |
| abstract_inverted_index.protein | 38 |
| abstract_inverted_index.reduced | 89, 162, 194 |
| abstract_inverted_index.similar | 105 |
| abstract_inverted_index.through | 52 |
| abstract_inverted_index.viruses | 138 |
| abstract_inverted_index.(eVP24), | 83 |
| abstract_inverted_index.However, | 156 |
| abstract_inverted_index.appeared | 139 |
| abstract_inverted_index.explains | 235 |
| abstract_inverted_index.knockout | 180 |
| abstract_inverted_index.mutation | 185, 192 |
| abstract_inverted_index.presence | 153 |
| abstract_inverted_index.proteins | 78 |
| abstract_inverted_index.relative | 79, 241 |
| abstract_inverted_index.residues | 247 |
| abstract_inverted_index.(IFN-β), | 230 |
| abstract_inverted_index.attenuate | 109, 207 |
| abstract_inverted_index.generated | 117 |
| abstract_inverted_index.interface | 101 |
| abstract_inverted_index.mutations | 129, 206 |
| abstract_inverted_index.response. | 115 |
| abstract_inverted_index.signaling | 51 |
| abstract_inverted_index.(IFN-λ1), | 227 |
| abstract_inverted_index.Bundibugyo | 20 |
| abstract_inverted_index.Ebolavirus | 3, 44 |
| abstract_inverted_index.affinities | 74 |
| abstract_inverted_index.antagonize | 113 |
| abstract_inverted_index.attenuated | 142 |
| abstract_inverted_index.attenuates | 251 |
| abstract_inverted_index.containing | 123 |
| abstract_inverted_index.correlated | 86 |
| abstract_inverted_index.inhibition | 90 |
| abstract_inverted_index.interface. | 134 |
| abstract_inverted_index.interferon | 49, 224, 228 |
| abstract_inverted_index.signaling. | 93 |
| abstract_inverted_index.suggesting | 203 |
| abstract_inverted_index.virulence. | 63 |
| abstract_inverted_index.Previously, | 64 |
| abstract_inverted_index.combination | 188 |
| abstract_inverted_index.demonstrate | 5 |
| abstract_inverted_index.differences | 8 |
| abstract_inverted_index.independent | 257 |
| abstract_inverted_index.interaction | 53 |
| abstract_inverted_index.karyopherin | 56, 76, 249 |
| abstract_inverted_index.mechanisms. | 258 |
| abstract_inverted_index.pathogenic, | 19, 23 |
| abstract_inverted_index.potentially | 60, 234 |
| abstract_inverted_index.recombinant | 121 |
| abstract_inverted_index.attenuation. | 213 |
| abstract_inverted_index.combinations | 126 |
| abstract_inverted_index.contributing | 61 |
| abstract_inverted_index.demonstrated | 66 |
| abstract_inverted_index.hypothesized | 95 |
| abstract_inverted_index.modification | 97 |
| abstract_inverted_index.Additionally, | 214 |
| abstract_inverted_index.pathogenicity | 10, 238 |
| abstract_inverted_index.transporters, | 59 |
| abstract_inverted_index.IFN-I-competent | 145 |
| abstract_inverted_index.IFN-I-deficient | 148 |
| abstract_inverted_index.IFN-I-dependent | 255 |
| abstract_inverted_index.IFN-I-independent | 212 |
| abstract_inverted_index.eVP24-karyopherin | 99, 132 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5015757298, https://openalex.org/A5054163903 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I55302922, https://openalex.org/I98704320 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/15 |
| sustainable_development_goals[0].score | 0.4399999976158142 |
| sustainable_development_goals[0].display_name | Life in Land |
| citation_normalized_percentile.value | 0.72347655 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |