Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination Article Swipe

PDF

Antonella Caputo , Carlos A. Guzmán , Clovis S. Palmer , Francesco Nicoli ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.3389/fcimb.2022.854241

The severity of bacterial and viral infections is linked to impaired immune and metabolic disorders, \ndisproportionally affecting individuals with metabolic comorbidities such as obesity, type 2 diabetes, \nand cardiovascular diseases. These metabolic disorders are also key predictors of adverse outcomes \nto infections. Infections by themselves promote both cellular and systemic metabolic alterations \nresulting in the development of long-term comorbidities. Indeed, the recent SARS-CoV-2 pandemic \nhighlighted this important connection, since metabolic complications emerged as key risk factors \nfor the development of severe forms of COVID-19 disease (Steenblock et al., 2021). However, the \nprecise molecular determinants of these associations remain unclear. A greater understanding on \nhow biochemical processes connect disease outcomes in viral and bacterial infections will facilitate \nthe development of more effective host-directed interventions and diagnostic tools for patient \nstratification or assessment of disease progression. Therefore, this Research Topic aimed at \nhighlighting work that: (1) disentangles how intrinsic immune cellar metabolic processes control \nviral replication and immunity, (2) dissect the metabolic requirements of immune cells during \nbacterial infections, and (3) examine systemic metabolic dysregulation during viral infections.

Related Topics

Concepts

Cell metabolism Vaccination Cellular metabolism Immunology Biology Microbiology Medicine Virology Metabolism Cell Genetics Endocrinology

Metadata

Type: editorial
Language: en
Landing Page: https://doi.org/10.3389/fcimb.2022.854241
PDF: https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf
OA Status: gold
Cited By: 2
References: 5
Related Works: 10
OpenAlex ID: https://openalex.org/W4214819342

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4214819342

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.3389/fcimb.2022.854241

Digital Object Identifier
Title: Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination

Work title
Type: editorial

OpenAlex work type
Language: en

Primary language
Publication year: 2022

Year of publication
Publication date: 2022-03-04

Full publication date if available
Authors: Antonella Caputo, Carlos A. Guzmán, Clovis S. Palmer, Francesco Nicoli

List of authors in order
Landing page: https://doi.org/10.3389/fcimb.2022.854241

Publisher landing page
PDF URL: https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: gold

Open access status per OpenAlex
OA URL: https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf

Direct OA link when available
Concepts: Cell metabolism, Vaccination, Cellular metabolism, Immunology, Biology, Microbiology, Medicine, Virology, Metabolism, Cell, Genetics, Endocrinology

Top concepts (fields/topics) attached by OpenAlex
Cited by: 2

Total citation count in OpenAlex
Citations by year (recent): 2024: 1, 2022: 1

Per-year citation counts (last 5 years)
References (count): 5

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4214819342
doi	https://doi.org/10.3389/fcimb.2022.854241
ids.doi	https://doi.org/10.3389/fcimb.2022.854241
ids.pmid	https://pubmed.ncbi.nlm.nih.gov/35310844
ids.openalex	https://openalex.org/W4214819342
fwci	0.25036359
type	editorial
title	Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination
biblio.issue
biblio.volume	12
biblio.last_page	854241
biblio.first_page	854241
topics[0].id	https://openalex.org/T10118
topics[0].field.id	https://openalex.org/fields/27
topics[0].field.display_name	Medicine
topics[0].score	0.9965000152587891
topics[0].domain.id	https://openalex.org/domains/4
topics[0].domain.display_name	Health Sciences
topics[0].subfield.id	https://openalex.org/subfields/2725
topics[0].subfield.display_name	Infectious Diseases
topics[0].display_name	SARS-CoV-2 and COVID-19 Research
topics[1].id	https://openalex.org/T10066
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.9958999752998352
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1312
topics[1].subfield.display_name	Molecular Biology
topics[1].display_name	Gut microbiota and health
topics[2].id	https://openalex.org/T11288
topics[2].field.id	https://openalex.org/fields/27
topics[2].field.display_name	Medicine
topics[2].score	0.9919000267982483
topics[2].domain.id	https://openalex.org/domains/4
topics[2].domain.display_name	Health Sciences
topics[2].subfield.id	https://openalex.org/subfields/2725
topics[2].subfield.display_name	Infectious Diseases
topics[2].display_name	Clostridium difficile and Clostridium perfringens research
is_xpac	False
apc_list.value	2950
apc_list.currency	USD
apc_list.value_usd	2950
apc_paid.value	2950
apc_paid.currency	USD
apc_paid.value_usd	2950
concepts[0].id	https://openalex.org/C2991704936
concepts[0].level	3
concepts[0].score	0.582339346408844
concepts[0].wikidata	https://www.wikidata.org/wiki/Q1057
concepts[0].display_name	Cell metabolism
concepts[1].id	https://openalex.org/C22070199
concepts[1].level	2
concepts[1].score	0.5784186124801636
concepts[1].wikidata	https://www.wikidata.org/wiki/Q192995
concepts[1].display_name	Vaccination
concepts[2].id	https://openalex.org/C2994212657
concepts[2].level	3
concepts[2].score	0.5684247016906738
concepts[2].wikidata	https://www.wikidata.org/wiki/Q1057
concepts[2].display_name	Cellular metabolism
concepts[3].id	https://openalex.org/C203014093
concepts[3].level	1
concepts[3].score	0.5007305145263672
concepts[3].wikidata	https://www.wikidata.org/wiki/Q101929
concepts[3].display_name	Immunology
concepts[4].id	https://openalex.org/C86803240
concepts[4].level	0
concepts[4].score	0.4308595657348633
concepts[4].wikidata	https://www.wikidata.org/wiki/Q420
concepts[4].display_name	Biology
concepts[5].id	https://openalex.org/C89423630
concepts[5].level	1
concepts[5].score	0.3440406620502472
concepts[5].wikidata	https://www.wikidata.org/wiki/Q7193
concepts[5].display_name	Microbiology
concepts[6].id	https://openalex.org/C71924100
concepts[6].level	0
concepts[6].score	0.34255868196487427
concepts[6].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[6].display_name	Medicine
concepts[7].id	https://openalex.org/C159047783
concepts[7].level	1
concepts[7].score	0.3339056968688965
concepts[7].wikidata	https://www.wikidata.org/wiki/Q7215
concepts[7].display_name	Virology
concepts[8].id	https://openalex.org/C62231903
concepts[8].level	2
concepts[8].score	0.2685004472732544
concepts[8].wikidata	https://www.wikidata.org/wiki/Q1057
concepts[8].display_name	Metabolism
concepts[9].id	https://openalex.org/C1491633281
concepts[9].level	2
concepts[9].score	0.250072717666626
concepts[9].wikidata	https://www.wikidata.org/wiki/Q7868
concepts[9].display_name	Cell
concepts[10].id	https://openalex.org/C54355233
concepts[10].level	1
concepts[10].score	0.10051634907722473
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[10].display_name	Genetics
concepts[11].id	https://openalex.org/C134018914
concepts[11].level	1
concepts[11].score	0.06723353266716003
concepts[11].wikidata	https://www.wikidata.org/wiki/Q162606
concepts[11].display_name	Endocrinology
keywords[0].id	https://openalex.org/keywords/cell-metabolism
keywords[0].score	0.582339346408844
keywords[0].display_name	Cell metabolism
keywords[1].id	https://openalex.org/keywords/vaccination
keywords[1].score	0.5784186124801636
keywords[1].display_name	Vaccination
keywords[2].id	https://openalex.org/keywords/cellular-metabolism
keywords[2].score	0.5684247016906738
keywords[2].display_name	Cellular metabolism
keywords[3].id	https://openalex.org/keywords/immunology
keywords[3].score	0.5007305145263672
keywords[3].display_name	Immunology
keywords[4].id	https://openalex.org/keywords/biology
keywords[4].score	0.4308595657348633
keywords[4].display_name	Biology
keywords[5].id	https://openalex.org/keywords/microbiology
keywords[5].score	0.3440406620502472
keywords[5].display_name	Microbiology
keywords[6].id	https://openalex.org/keywords/medicine
keywords[6].score	0.34255868196487427
keywords[6].display_name	Medicine
keywords[7].id	https://openalex.org/keywords/virology
keywords[7].score	0.3339056968688965
keywords[7].display_name	Virology
keywords[8].id	https://openalex.org/keywords/metabolism
keywords[8].score	0.2685004472732544
keywords[8].display_name	Metabolism
keywords[9].id	https://openalex.org/keywords/cell
keywords[9].score	0.250072717666626
keywords[9].display_name	Cell
keywords[10].id	https://openalex.org/keywords/genetics
keywords[10].score	0.10051634907722473
keywords[10].display_name	Genetics
keywords[11].id	https://openalex.org/keywords/endocrinology
keywords[11].score	0.06723353266716003
keywords[11].display_name	Endocrinology
language	en
locations[0].id	doi:10.3389/fcimb.2022.854241
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S2506667490
locations[0].source.issn	2235-2988
locations[0].source.type	journal
locations[0].source.is_oa	True
locations[0].source.issn_l	2235-2988
locations[0].source.is_core	True
locations[0].source.is_in_doaj	True
locations[0].source.display_name	Frontiers in Cellular and Infection Microbiology
locations[0].source.host_organization	https://openalex.org/P4310320527
locations[0].source.host_organization_name	Frontiers Media
locations[0].source.host_organization_lineage	https://openalex.org/P4310320527
locations[0].license	cc-by
locations[0].pdf_url	https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf
locations[0].version	publishedVersion
locations[0].raw_type	journal-article
locations[0].license_id	https://openalex.org/licenses/cc-by
locations[0].is_accepted	True
locations[0].is_published	True
locations[0].raw_source_name	Frontiers in Cellular and Infection Microbiology
locations[0].landing_page_url	https://doi.org/10.3389/fcimb.2022.854241
locations[1].id	pmid:35310844
locations[1].is_oa	False
locations[1].source.id	https://openalex.org/S4306525036
locations[1].source.issn
locations[1].source.type	repository
locations[1].source.is_oa	False
locations[1].source.issn_l
locations[1].source.is_core	False
locations[1].source.is_in_doaj	False
locations[1].source.display_name	PubMed
locations[1].source.host_organization	https://openalex.org/I1299303238
locations[1].source.host_organization_name	National Institutes of Health
locations[1].source.host_organization_lineage	https://openalex.org/I1299303238
locations[1].license
locations[1].pdf_url
locations[1].version	publishedVersion
locations[1].raw_type
locations[1].license_id
locations[1].is_accepted	True
locations[1].is_published	True
locations[1].raw_source_name	Frontiers in cellular and infection microbiology
locations[1].landing_page_url	https://pubmed.ncbi.nlm.nih.gov/35310844
locations[2].id	pmh:oai:iris.unife.it:11392/2481312
locations[2].is_oa	True
locations[2].source.id	https://openalex.org/S4306400369
locations[2].source.issn
locations[2].source.type	repository
locations[2].source.is_oa	False
locations[2].source.issn_l
locations[2].source.is_core	False
locations[2].source.is_in_doaj	False
locations[2].source.display_name	Institutional Research Information System University of Ferrara (University of Ferrara)
locations[2].source.host_organization	https://openalex.org/I201324441
locations[2].source.host_organization_name	University of Ferrara
locations[2].source.host_organization_lineage	https://openalex.org/I201324441
locations[2].license	other-oa
locations[2].pdf_url
locations[2].version	submittedVersion
locations[2].raw_type	info:eu-repo/semantics/article
locations[2].license_id	https://openalex.org/licenses/other-oa
locations[2].is_accepted	False
locations[2].is_published	False
locations[2].raw_source_name
locations[2].landing_page_url	https://hdl.handle.net/11392/2481312
locations[3].id	pmh:oai:doaj.org/article:b6665e1cc3c34756b6ba3ec8c184a30b
locations[3].is_oa	True
locations[3].source.id	https://openalex.org/S4306401280
locations[3].source.issn
locations[3].source.type	repository
locations[3].source.is_oa	False
locations[3].source.issn_l
locations[3].source.is_core	False
locations[3].source.is_in_doaj	False
locations[3].source.display_name	DOAJ (DOAJ: Directory of Open Access Journals)
locations[3].source.host_organization
locations[3].source.host_organization_name
locations[3].source.host_organization_lineage
locations[3].license	cc-by-sa
locations[3].pdf_url
locations[3].version	submittedVersion
locations[3].raw_type	article
locations[3].license_id	https://openalex.org/licenses/cc-by-sa
locations[3].is_accepted	False
locations[3].is_published	False
locations[3].raw_source_name	Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
locations[3].landing_page_url	https://doaj.org/article/b6665e1cc3c34756b6ba3ec8c184a30b
locations[4].id	pmh:oai:pubmedcentral.nih.gov:8931307
locations[4].is_oa	True
locations[4].source.id	https://openalex.org/S2764455111
locations[4].source.issn
locations[4].source.type	repository
locations[4].source.is_oa	False
locations[4].source.issn_l
locations[4].source.is_core	False
locations[4].source.is_in_doaj	False
locations[4].source.display_name	PubMed Central
locations[4].source.host_organization	https://openalex.org/I1299303238
locations[4].source.host_organization_name	National Institutes of Health
locations[4].source.host_organization_lineage	https://openalex.org/I1299303238
locations[4].license	other-oa
locations[4].pdf_url
locations[4].version	submittedVersion
locations[4].raw_type	Text
locations[4].license_id	https://openalex.org/licenses/other-oa
locations[4].is_accepted	False
locations[4].is_published	False
locations[4].raw_source_name	Front Cell Infect Microbiol
locations[4].landing_page_url	https://www.ncbi.nlm.nih.gov/pmc/articles/8931307
locations[5].id	pmh:oai:sfera.unife.it:11392/2481312
locations[5].is_oa	True
locations[5].source
locations[5].license	cc-by
locations[5].pdf_url
locations[5].version	submittedVersion
locations[5].raw_type	info:eu-repo/semantics/article
locations[5].license_id	https://openalex.org/licenses/cc-by
locations[5].is_accepted	False
locations[5].is_published	False
locations[5].raw_source_name
locations[5].landing_page_url	https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/full
indexed_in	crossref, doaj, pubmed
authorships[0].author.id	https://openalex.org/A5032382293
authorships[0].author.orcid	https://orcid.org/0000-0002-1241-0299
authorships[0].author.display_name	Antonella Caputo
authorships[0].countries	IT
authorships[0].affiliations[0].institution_ids	https://openalex.org/I201324441
authorships[0].affiliations[0].raw_affiliation_string	Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy
authorships[0].institutions[0].id	https://openalex.org/I201324441
authorships[0].institutions[0].ror	https://ror.org/041zkgm14
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I201324441
authorships[0].institutions[0].country_code	IT
authorships[0].institutions[0].display_name	University of Ferrara
authorships[0].author_position	first
authorships[0].raw_author_name	Antonella Caputo
authorships[0].is_corresponding	True
authorships[0].raw_affiliation_strings	Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy
authorships[1].author.id	https://openalex.org/A5044311719
authorships[1].author.orcid	https://orcid.org/0000-0002-2913-5254
authorships[1].author.display_name	Carlos A. Guzmán
authorships[1].countries	DE
authorships[1].affiliations[0].institution_ids	https://openalex.org/I4210124929
authorships[1].affiliations[0].raw_affiliation_string	Department Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
authorships[1].institutions[0].id	https://openalex.org/I4210124929
authorships[1].institutions[0].ror	https://ror.org/03d0p2685
authorships[1].institutions[0].type	facility
authorships[1].institutions[0].lineage	https://openalex.org/I1305996414, https://openalex.org/I4210124929
authorships[1].institutions[0].country_code	DE
authorships[1].institutions[0].display_name	Helmholtz Centre for Infection Research
authorships[1].author_position	middle
authorships[1].raw_author_name	Carlos A. Guzman
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Department Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, Braunschweig, Germany
authorships[2].author.id	https://openalex.org/A5059050863
authorships[2].author.orcid	https://orcid.org/0000-0002-5031-6922
authorships[2].author.display_name	Clovis S. Palmer
authorships[2].countries	US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I114832834
authorships[2].affiliations[0].raw_affiliation_string	Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States
authorships[2].institutions[0].id	https://openalex.org/I114832834
authorships[2].institutions[0].ror	https://ror.org/04vmvtb21
authorships[2].institutions[0].type	education
authorships[2].institutions[0].lineage	https://openalex.org/I114832834
authorships[2].institutions[0].country_code	US
authorships[2].institutions[0].display_name	Tulane University
authorships[2].author_position	middle
authorships[2].raw_author_name	Clovis S. Palmer
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, United States
authorships[3].author.id	https://openalex.org/A5062931638
authorships[3].author.orcid	https://orcid.org/0000-0001-6327-5958
authorships[3].author.display_name	Francesco Nicoli
authorships[3].countries	IT
authorships[3].affiliations[0].institution_ids	https://openalex.org/I201324441
authorships[3].affiliations[0].raw_affiliation_string	Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy
authorships[3].institutions[0].id	https://openalex.org/I201324441
authorships[3].institutions[0].ror	https://ror.org/041zkgm14
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I201324441
authorships[3].institutions[0].country_code	IT
authorships[3].institutions[0].display_name	University of Ferrara
authorships[3].author_position	last
authorships[3].raw_author_name	Francesco Nicoli
authorships[3].is_corresponding	True
authorships[3].raw_affiliation_strings	Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf
open_access.oa_status	gold
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Editorial: The Role of Systemic and Cellular Metabolism on Susceptibility to Infections and Responsiveness to Vaccination
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T10118
primary_topic.field.id	https://openalex.org/fields/27
primary_topic.field.display_name	Medicine
primary_topic.score	0.9965000152587891
primary_topic.domain.id	https://openalex.org/domains/4
primary_topic.domain.display_name	Health Sciences
primary_topic.subfield.id	https://openalex.org/subfields/2725
primary_topic.subfield.display_name	Infectious Diseases
primary_topic.display_name	SARS-CoV-2 and COVID-19 Research
related_works	https://openalex.org/W2773698249, https://openalex.org/W2740812009, https://openalex.org/W2091534100, https://openalex.org/W4388451211, https://openalex.org/W77723393, https://openalex.org/W2057891455, https://openalex.org/W3127076128, https://openalex.org/W4251741602, https://openalex.org/W4283018507, https://openalex.org/W2905430175
cited_by_count	2
counts_by_year[0].year	2024
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2022
counts_by_year[1].cited_by_count	1
locations_count	6
best_oa_location.id	doi:10.3389/fcimb.2022.854241
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S2506667490
best_oa_location.source.issn	2235-2988
best_oa_location.source.type	journal
best_oa_location.source.is_oa	True
best_oa_location.source.issn_l	2235-2988
best_oa_location.source.is_core	True
best_oa_location.source.is_in_doaj	True
best_oa_location.source.display_name	Frontiers in Cellular and Infection Microbiology
best_oa_location.source.host_organization	https://openalex.org/P4310320527
best_oa_location.source.host_organization_name	Frontiers Media
best_oa_location.source.host_organization_lineage	https://openalex.org/P4310320527
best_oa_location.license	cc-by
best_oa_location.pdf_url	https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf
best_oa_location.version	publishedVersion
best_oa_location.raw_type	journal-article
best_oa_location.license_id	https://openalex.org/licenses/cc-by
best_oa_location.is_accepted	True
best_oa_location.is_published	True
best_oa_location.raw_source_name	Frontiers in Cellular and Infection Microbiology
best_oa_location.landing_page_url	https://doi.org/10.3389/fcimb.2022.854241
primary_location.id	doi:10.3389/fcimb.2022.854241
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S2506667490
primary_location.source.issn	2235-2988
primary_location.source.type	journal
primary_location.source.is_oa	True
primary_location.source.issn_l	2235-2988
primary_location.source.is_core	True
primary_location.source.is_in_doaj	True
primary_location.source.display_name	Frontiers in Cellular and Infection Microbiology
primary_location.source.host_organization	https://openalex.org/P4310320527
primary_location.source.host_organization_name	Frontiers Media
primary_location.source.host_organization_lineage	https://openalex.org/P4310320527
primary_location.license	cc-by
primary_location.pdf_url	https://www.frontiersin.org/articles/10.3389/fcimb.2022.854241/pdf
primary_location.version	publishedVersion
primary_location.raw_type	journal-article
primary_location.license_id	https://openalex.org/licenses/cc-by
primary_location.is_accepted	True
primary_location.is_published	True
primary_location.raw_source_name	Frontiers in Cellular and Infection Microbiology
primary_location.landing_page_url	https://doi.org/10.3389/fcimb.2022.854241
publication_date	2022-03-04
publication_year	2022
referenced_works	https://openalex.org/W3169168293, https://openalex.org/W2922860464, https://openalex.org/W3091428163, https://openalex.org/W3135722663, https://openalex.org/W3202042764
referenced_works_count	5
abstract_inverted_index.2	24
abstract_inverted_index.A	92
abstract_inverted_index.as	21, 67
abstract_inverted_index.by	40
abstract_inverted_index.et	80
abstract_inverted_index.in	49, 101
abstract_inverted_index.is	7
abstract_inverted_index.of	2, 35, 52, 73, 76, 87, 109, 121, 149
abstract_inverted_index.or	119
abstract_inverted_index.to	9
abstract_inverted_index.(1)	132
abstract_inverted_index.(2)	144
abstract_inverted_index.(3)	155
abstract_inverted_index.The	0
abstract_inverted_index.and	4, 12, 45, 103, 114, 142, 154
abstract_inverted_index.are	31
abstract_inverted_index.for	117
abstract_inverted_index.how	134
abstract_inverted_index.key	33, 68
abstract_inverted_index.the	50, 56, 71, 146
abstract_inverted_index.al.,	81
abstract_inverted_index.also	32
abstract_inverted_index.both	43
abstract_inverted_index.more	110
abstract_inverted_index.risk	69
abstract_inverted_index.such	20
abstract_inverted_index.this	60, 125
abstract_inverted_index.type	23
abstract_inverted_index.will	106
abstract_inverted_index.with	17
abstract_inverted_index.work	130
abstract_inverted_index.These	28
abstract_inverted_index.Topic	127
abstract_inverted_index.aimed	128
abstract_inverted_index.cells	151
abstract_inverted_index.forms	75
abstract_inverted_index.since	63
abstract_inverted_index.that:	131
abstract_inverted_index.these	88
abstract_inverted_index.tools	116
abstract_inverted_index.viral	5, 102, 161
abstract_inverted_index.2021).	82
abstract_inverted_index.cellar	137
abstract_inverted_index.during	160
abstract_inverted_index.immune	11, 136, 150
abstract_inverted_index.linked	8
abstract_inverted_index.recent	57
abstract_inverted_index.remain	90
abstract_inverted_index.severe	74
abstract_inverted_index.Indeed,	55
abstract_inverted_index.adverse	36
abstract_inverted_index.connect	98
abstract_inverted_index.disease	78, 99, 122
abstract_inverted_index.dissect	145
abstract_inverted_index.emerged	66
abstract_inverted_index.examine	156
abstract_inverted_index.greater	93
abstract_inverted_index.promote	42
abstract_inverted_index.COVID-19	77
abstract_inverted_index.However,	83
abstract_inverted_index.Research	126
abstract_inverted_index.cellular	44
abstract_inverted_index.impaired	10
abstract_inverted_index.obesity,	22
abstract_inverted_index.outcomes	100
abstract_inverted_index.severity	1
abstract_inverted_index.systemic	46, 157
abstract_inverted_index.unclear.	91
abstract_inverted_index.affecting	15
abstract_inverted_index.bacterial	3, 104
abstract_inverted_index.diseases.	27
abstract_inverted_index.disorders	30
abstract_inverted_index.effective	111
abstract_inverted_index.immunity,	143
abstract_inverted_index.important	61
abstract_inverted_index.intrinsic	135
abstract_inverted_index.long-term	53
abstract_inverted_index.metabolic	13, 18, 29, 47, 64, 138, 147, 158
abstract_inverted_index.molecular	85
abstract_inverted_index.processes	97, 139
abstract_inverted_index.Infections	39
abstract_inverted_index.SARS-CoV-2	58
abstract_inverted_index.Therefore,	124
abstract_inverted_index.assessment	120
abstract_inverted_index.diagnostic	115
abstract_inverted_index.infections	6, 105
abstract_inverted_index.predictors	34
abstract_inverted_index.themselves	41
abstract_inverted_index.(Steenblock	79
abstract_inverted_index.biochemical	96
abstract_inverted_index.connection,	62
abstract_inverted_index.development	51, 72, 108
abstract_inverted_index.individuals	16
abstract_inverted_index.infections,	153
abstract_inverted_index.infections.	38, 162
abstract_inverted_index.replication	141
abstract_inverted_index.associations	89
abstract_inverted_index.determinants	86
abstract_inverted_index.disentangles	133
abstract_inverted_index.on \nhow	95
abstract_inverted_index.progression.	123
abstract_inverted_index.requirements	148
abstract_inverted_index.comorbidities	19
abstract_inverted_index.complications	65
abstract_inverted_index.dysregulation	159
abstract_inverted_index.host-directed	112
abstract_inverted_index.interventions	113
abstract_inverted_index.understanding	94
abstract_inverted_index.cardiovascular	26
abstract_inverted_index.comorbidities.	54
abstract_inverted_index.factors \nfor	70
abstract_inverted_index.outcomes \nto	37
abstract_inverted_index.the \nprecise	84
abstract_inverted_index.control \nviral	140
abstract_inverted_index.diabetes, \nand	25
abstract_inverted_index.facilitate \nthe	107
abstract_inverted_index.at \nhighlighting	129
abstract_inverted_index.during \nbacterial	152
abstract_inverted_index.pandemic \nhighlighted	59
abstract_inverted_index.alterations \nresulting	48
abstract_inverted_index.patient \nstratification	118
abstract_inverted_index.disorders, \ndisproportionally	14
cited_by_percentile_year.max	94
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5062931638, https://openalex.org/A5032382293
countries_distinct_count	3
institutions_distinct_count	4
corresponding_institution_ids	https://openalex.org/I201324441
sustainable_development_goals[0].id	https://metadata.un.org/sdg/2
sustainable_development_goals[0].score	0.41999998688697815
sustainable_development_goals[0].display_name	Zero hunger
citation_normalized_percentile.value	0.4917879
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	False