Edoxaban for 12 vs. 3 months in cancer-associated isolated distal deep vein thrombosis according to different doses: insights from the ONCO DVT study Article Swipe
Ryuki Chatani
,
Yugo Yamashita
,
Takeshi Morimoto
,
Nao Muraoka
,
Michihisa Umetsu
,
Yuji Nishimoto
,
Takuma Takada
,
Yoshito Ogihara
,
Tatsuya Nishikawa
,
Nobutaka Ikeda
,
Kazunori Otsui
,
Daisuke Sueta
,
Yukari Tsubata
,
Masaaki Shoji
,
Ayumi Shikama
,
Yutaka Hosoi
,
Yasuhiro Tanabe
,
Kengo Tsukahara
,
Naohiko Nakanishi
,
Kitae Kim
,
Satoshi Ikeda
,
Kazunori Mushiake
,
Kazushige Kadota
,
Koh Ono
,
Takeshi Kimura
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ehjcvp/pvae028
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1093/ehjcvp/pvae028
Background The ONCO DVT study revealed the superiority of 12-month relative to 3-month edoxaban treatment for cancer-associated isolated distal deep vein thrombosis (DVT) regarding the thrombotic risk. Methods and Results In this pre-specified subgroup analysis of the ONCO DVT study, we stratified the patients into those with a standard edoxaban dose (60 mg/day; N = 151) and those with a reduced edoxaban dose (30 mg/day; N = 450) and evaluated the clinical outcomes for the 12- and 3-month treatments. The cumulative 12-month incidence of symptomatic recurrent venous thromboembolism was lower in the 12-month than 3-month group for both the 60 mg (1.3% vs. 11.6%, P = 0.02; odds ratio [OR], 0.12; 95% confidence interval [CI], 0.01–0.97) and 30 mg (1.1% vs. 7.6%, P = 0.002; OR, 0.14; 95% CI, 0.03–0.60) edoxaban subgroups, which was consistent across the edoxaban doses without a significant interaction (P = 0.90). The 12-month cumulative incidence of major bleeding was higher in the 12-month group than in the 3-month group for the 60 mg edoxaban subgroup (14.3% vs. 4.4%, P = 0.046; OR, 3.61; 95% CI, 0.97–13.52), whereas it did not significantly differ between the two groups for the 30 mg edoxaban subgroup (8.7% vs. 8.6%, P = 0.89; OR, 0.97; 95% CI, 0.49–1.91), signalling there was a potential interaction (P = 0.07). Conclusions A 12-month edoxaban regimen for cancer-associated isolated distal DVT was consistently superior to a 3-month regimen, across the edoxaban doses for the thrombotic risk. However, caution was suggested for the standard dose of edoxaban due to the potential for an increased risk of bleeding with prolonged anticoagulation therapy. Trial registration number NCT03895502 (ONCO DVT Trial): https://classic.clinicaltrials.gov/ct2/show/NCT03895502
Related Topics
Concepts
Edoxaban
Medicine
Deep vein
Thrombosis
Cancer
Internal medicine
Warfarin
Rivaroxaban
Atrial fibrillation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ehjcvp/pvae028
- https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdf
- OA Status
- hybrid
- Cited By
- 5
- References
- 23
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395051328
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4395051328Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/ehjcvp/pvae028Digital Object Identifier
- Title
-
Edoxaban for 12 vs. 3 months in cancer-associated isolated distal deep vein thrombosis according to different doses: insights from the ONCO DVT studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-22Full publication date if available
- Authors
-
Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Michihisa Umetsu, Yuji Nishimoto, Takuma Takada, Yoshito Ogihara, Tatsuya Nishikawa, Nobutaka Ikeda, Kazunori Otsui, Daisuke Sueta, Yukari Tsubata, Masaaki Shoji, Ayumi Shikama, Yutaka Hosoi, Yasuhiro Tanabe, Kengo Tsukahara, Naohiko Nakanishi, Kitae Kim, Satoshi Ikeda, Kazunori Mushiake, Kazushige Kadota, Koh Ono, Takeshi KimuraList of authors in order
- Landing page
-
https://doi.org/10.1093/ehjcvp/pvae028Publisher landing page
- PDF URL
-
https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdfDirect OA link when available
- Concepts
-
Edoxaban, Medicine, Deep vein, Thrombosis, Cancer, Internal medicine, Warfarin, Rivaroxaban, Atrial fibrillationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
23Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4395051328 |
|---|---|
| doi | https://doi.org/10.1093/ehjcvp/pvae028 |
| ids.doi | https://doi.org/10.1093/ehjcvp/pvae028 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38650055 |
| ids.openalex | https://openalex.org/W4395051328 |
| fwci | 5.61562572 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000175 |
| mesh[1].descriptor_ui | D020246 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | diagnosis |
| mesh[1].descriptor_name | Venous Thrombosis |
| mesh[2].qualifier_ui | Q000453 |
| mesh[2].descriptor_ui | D020246 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | epidemiology |
| mesh[2].descriptor_name | Venous Thrombosis |
| mesh[3].qualifier_ui | Q000188 |
| mesh[3].descriptor_ui | D020246 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug therapy |
| mesh[3].descriptor_name | Venous Thrombosis |
| mesh[4].qualifier_ui | Q000008 |
| mesh[4].descriptor_ui | D013844 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | administration & dosage |
| mesh[4].descriptor_name | Thiazoles |
| mesh[5].qualifier_ui | Q000009 |
| mesh[5].descriptor_ui | D013844 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | adverse effects |
| mesh[5].descriptor_name | Thiazoles |
| mesh[6].qualifier_ui | Q000008 |
| mesh[6].descriptor_ui | D011725 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | administration & dosage |
| mesh[6].descriptor_name | Pyridines |
| mesh[7].qualifier_ui | Q000009 |
| mesh[7].descriptor_ui | D011725 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | adverse effects |
| mesh[7].descriptor_name | Pyridines |
| mesh[8].qualifier_ui | Q000008 |
| mesh[8].descriptor_ui | D065427 |
| mesh[8].is_major_topic | True |
| mesh[8].qualifier_name | administration & dosage |
| mesh[8].descriptor_name | Factor Xa Inhibitors |
| mesh[9].qualifier_ui | Q000009 |
| mesh[9].descriptor_ui | D065427 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | adverse effects |
| mesh[9].descriptor_name | Factor Xa Inhibitors |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005260 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Female |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008297 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Male |
| mesh[12].qualifier_ui | Q000150 |
| mesh[12].descriptor_ui | D009369 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | complications |
| mesh[12].descriptor_name | Neoplasms |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008875 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Middle Aged |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D000368 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Aged |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D013997 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Time Factors |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D016896 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Treatment Outcome |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D012307 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Risk Factors |
| mesh[18].qualifier_ui | Q000139 |
| mesh[18].descriptor_ui | D006470 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | chemically induced |
| mesh[18].descriptor_name | Hemorrhage |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D012008 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Recurrence |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D004334 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Drug Administration Schedule |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D015994 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Incidence |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D004311 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Double-Blind Method |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D006801 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Humans |
| mesh[24].qualifier_ui | Q000175 |
| mesh[24].descriptor_ui | D020246 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | diagnosis |
| mesh[24].descriptor_name | Venous Thrombosis |
| mesh[25].qualifier_ui | Q000453 |
| mesh[25].descriptor_ui | D020246 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | epidemiology |
| mesh[25].descriptor_name | Venous Thrombosis |
| mesh[26].qualifier_ui | Q000188 |
| mesh[26].descriptor_ui | D020246 |
| mesh[26].is_major_topic | True |
| mesh[26].qualifier_name | drug therapy |
| mesh[26].descriptor_name | Venous Thrombosis |
| mesh[27].qualifier_ui | Q000008 |
| mesh[27].descriptor_ui | D013844 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | administration & dosage |
| mesh[27].descriptor_name | Thiazoles |
| mesh[28].qualifier_ui | Q000009 |
| mesh[28].descriptor_ui | D013844 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | adverse effects |
| mesh[28].descriptor_name | Thiazoles |
| mesh[29].qualifier_ui | Q000008 |
| mesh[29].descriptor_ui | D011725 |
| mesh[29].is_major_topic | True |
| mesh[29].qualifier_name | administration & dosage |
| mesh[29].descriptor_name | Pyridines |
| mesh[30].qualifier_ui | Q000009 |
| mesh[30].descriptor_ui | D011725 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | adverse effects |
| mesh[30].descriptor_name | Pyridines |
| mesh[31].qualifier_ui | Q000008 |
| mesh[31].descriptor_ui | D065427 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | administration & dosage |
| mesh[31].descriptor_name | Factor Xa Inhibitors |
| mesh[32].qualifier_ui | Q000009 |
| mesh[32].descriptor_ui | D065427 |
| mesh[32].is_major_topic | True |
| mesh[32].qualifier_name | adverse effects |
| mesh[32].descriptor_name | Factor Xa Inhibitors |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D005260 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Female |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D008297 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Male |
| mesh[35].qualifier_ui | Q000150 |
| mesh[35].descriptor_ui | D009369 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | complications |
| mesh[35].descriptor_name | Neoplasms |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D008875 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Middle Aged |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D000368 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Aged |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D013997 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Time Factors |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D016896 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Treatment Outcome |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D012307 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Risk Factors |
| mesh[41].qualifier_ui | Q000139 |
| mesh[41].descriptor_ui | D006470 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | chemically induced |
| mesh[41].descriptor_name | Hemorrhage |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D012008 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Recurrence |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D004334 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Drug Administration Schedule |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D015994 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Incidence |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D004311 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Double-Blind Method |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D006801 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Humans |
| mesh[47].qualifier_ui | Q000175 |
| mesh[47].descriptor_ui | D020246 |
| mesh[47].is_major_topic | True |
| mesh[47].qualifier_name | diagnosis |
| mesh[47].descriptor_name | Venous Thrombosis |
| mesh[48].qualifier_ui | Q000453 |
| mesh[48].descriptor_ui | D020246 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | epidemiology |
| mesh[48].descriptor_name | Venous Thrombosis |
| mesh[49].qualifier_ui | Q000188 |
| mesh[49].descriptor_ui | D020246 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | drug therapy |
| mesh[49].descriptor_name | Venous Thrombosis |
| type | article |
| title | Edoxaban for 12 vs. 3 months in cancer-associated isolated distal deep vein thrombosis according to different doses: insights from the ONCO DVT study |
| biblio.issue | 5 |
| biblio.volume | 10 |
| biblio.last_page | 431 |
| biblio.first_page | 422 |
| topics[0].id | https://openalex.org/T10285 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2724 |
| topics[0].subfield.display_name | Internal Medicine |
| topics[0].display_name | Venous Thromboembolism Diagnosis and Management |
| topics[1].id | https://openalex.org/T10065 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9987999796867371 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2705 |
| topics[1].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[1].display_name | Atrial Fibrillation Management and Outcomes |
| topics[2].id | https://openalex.org/T11217 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9941999912261963 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2705 |
| topics[2].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[2].display_name | Cardiac Arrhythmias and Treatments |
| is_xpac | False |
| apc_list.value | 3612 |
| apc_list.currency | EUR |
| apc_list.value_usd | 3895 |
| apc_paid.value | 3612 |
| apc_paid.currency | EUR |
| apc_paid.value_usd | 3895 |
| concepts[0].id | https://openalex.org/C2780290652 |
| concepts[0].level | 5 |
| concepts[0].score | 0.9043874144554138 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q21011234 |
| concepts[0].display_name | Edoxaban |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.8585371971130371 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2778959117 |
| concepts[2].level | 3 |
| concepts[2].score | 0.846943736076355 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q430892 |
| concepts[2].display_name | Deep vein |
| concepts[3].id | https://openalex.org/C2780868729 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6894887685775757 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q261327 |
| concepts[3].display_name | Thrombosis |
| concepts[4].id | https://openalex.org/C121608353 |
| concepts[4].level | 2 |
| concepts[4].score | 0.6069777011871338 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q12078 |
| concepts[4].display_name | Cancer |
| concepts[5].id | https://openalex.org/C126322002 |
| concepts[5].level | 1 |
| concepts[5].score | 0.3447122275829315 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[5].display_name | Internal medicine |
| concepts[6].id | https://openalex.org/C2776301958 |
| concepts[6].level | 3 |
| concepts[6].score | 0.08641305565834045 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q407431 |
| concepts[6].display_name | Warfarin |
| concepts[7].id | https://openalex.org/C2778661090 |
| concepts[7].level | 4 |
| concepts[7].score | 0.07430702447891235 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420262 |
| concepts[7].display_name | Rivaroxaban |
| concepts[8].id | https://openalex.org/C2779161974 |
| concepts[8].level | 2 |
| concepts[8].score | 0.0535205602645874 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q815819 |
| concepts[8].display_name | Atrial fibrillation |
| keywords[0].id | https://openalex.org/keywords/edoxaban |
| keywords[0].score | 0.9043874144554138 |
| keywords[0].display_name | Edoxaban |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.8585371971130371 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/deep-vein |
| keywords[2].score | 0.846943736076355 |
| keywords[2].display_name | Deep vein |
| keywords[3].id | https://openalex.org/keywords/thrombosis |
| keywords[3].score | 0.6894887685775757 |
| keywords[3].display_name | Thrombosis |
| keywords[4].id | https://openalex.org/keywords/cancer |
| keywords[4].score | 0.6069777011871338 |
| keywords[4].display_name | Cancer |
| keywords[5].id | https://openalex.org/keywords/internal-medicine |
| keywords[5].score | 0.3447122275829315 |
| keywords[5].display_name | Internal medicine |
| keywords[6].id | https://openalex.org/keywords/warfarin |
| keywords[6].score | 0.08641305565834045 |
| keywords[6].display_name | Warfarin |
| keywords[7].id | https://openalex.org/keywords/rivaroxaban |
| keywords[7].score | 0.07430702447891235 |
| keywords[7].display_name | Rivaroxaban |
| keywords[8].id | https://openalex.org/keywords/atrial-fibrillation |
| keywords[8].score | 0.0535205602645874 |
| keywords[8].display_name | Atrial fibrillation |
| language | en |
| locations[0].id | doi:10.1093/ehjcvp/pvae028 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2735768669 |
| locations[0].source.issn | 2055-6837, 2055-6845 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 2055-6837 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| locations[0].source.host_organization | https://openalex.org/P4310311648 |
| locations[0].source.host_organization_name | Oxford University Press |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| locations[0].source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| locations[0].landing_page_url | https://doi.org/10.1093/ehjcvp/pvae028 |
| locations[1].id | pmid:38650055 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | European heart journal. Cardiovascular pharmacotherapy |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38650055 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11323369 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Eur Heart J Cardiovasc Pharmacother |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11323369 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5024226964 |
| authorships[0].author.orcid | https://orcid.org/0009-0009-7622-8494 |
| authorships[0].author.display_name | Ryuki Chatani |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210089671 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[0].institutions[0].id | https://openalex.org/I4210089671 |
| authorships[0].institutions[0].ror | https://ror.org/00947s692 |
| authorships[0].institutions[0].type | healthcare |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210089671 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Kurashiki Central Hospital |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ryuki Chatani |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[1].author.id | https://openalex.org/A5043428080 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-2583-1321 |
| authorships[1].author.display_name | Yugo Yamashita |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I22299242 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University , 54 Shogoin Kawahara-cho, Sakyo-ku, 6068507 Kyoto , Japan |
| authorships[1].institutions[0].id | https://openalex.org/I22299242 |
| authorships[1].institutions[0].ror | https://ror.org/02kpeqv85 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I22299242 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Kyoto University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Yugo Yamashita |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University , 54 Shogoin Kawahara-cho, Sakyo-ku, 6068507 Kyoto , Japan |
| authorships[2].author.id | https://openalex.org/A5080185082 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-6844-739X |
| authorships[2].author.display_name | Takeshi Morimoto |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I84059937 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Clinical Epidemiology, Hyogo Medical University , Nishinomiya 6638501 , Japan |
| authorships[2].institutions[0].id | https://openalex.org/I84059937 |
| authorships[2].institutions[0].ror | https://ror.org/024pdem44 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I84059937 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Hyogo University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Takeshi Morimoto |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Clinical Epidemiology, Hyogo Medical University , Nishinomiya 6638501 , Japan |
| authorships[3].author.id | https://openalex.org/A5001682281 |
| authorships[3].author.orcid | https://orcid.org/0009-0007-3564-039X |
| authorships[3].author.display_name | Nao Muraoka |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210088324 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Cardiology, Shizuoka Cancer Center , Shizuoka 4118777 , Japan |
| authorships[3].institutions[0].id | https://openalex.org/I4210088324 |
| authorships[3].institutions[0].ror | https://ror.org/0042ytd14 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210088324 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Shizuoka Cancer Center |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Nao Muraoka |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Cardiology, Shizuoka Cancer Center , Shizuoka 4118777 , Japan |
| authorships[4].author.id | https://openalex.org/A5047728101 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1080-2491 |
| authorships[4].author.display_name | Michihisa Umetsu |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210093896 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Vascular Surgery, Department of Surgery, Tohoku University Hospital , Sendai 9808574 , Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210093896 |
| authorships[4].institutions[0].ror | https://ror.org/00kcd6x60 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210093896 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Tohoku University Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Michihisa Umetsu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Vascular Surgery, Department of Surgery, Tohoku University Hospital , Sendai 9808574 , Japan |
| authorships[5].author.id | https://openalex.org/A5071868544 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-1996-8540 |
| authorships[5].author.display_name | Yuji Nishimoto |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I3019022944, https://openalex.org/I4210099064 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Cardiology, Osaka General Medical Center , Osaka 5588558 , Japan |
| authorships[5].institutions[0].id | https://openalex.org/I4210099064 |
| authorships[5].institutions[0].ror | https://ror.org/00v053551 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210099064 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Osaka City General Hospital |
| authorships[5].institutions[1].id | https://openalex.org/I3019022944 |
| authorships[5].institutions[1].ror | https://ror.org/00vcb6036 |
| authorships[5].institutions[1].type | healthcare |
| authorships[5].institutions[1].lineage | https://openalex.org/I3019022944 |
| authorships[5].institutions[1].country_code | JP |
| authorships[5].institutions[1].display_name | Osaka Prefectural Medical Center |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Yuji Nishimoto |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Cardiology, Osaka General Medical Center , Osaka 5588558 , Japan |
| authorships[6].author.id | https://openalex.org/A5082006884 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-9172-0163 |
| authorships[6].author.display_name | Takuma Takada |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210136522 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Cardiology, Tokyo Women's Medical University , Tokyo 1628666 , Japan |
| authorships[6].institutions[0].id | https://openalex.org/I4210136522 |
| authorships[6].institutions[0].ror | https://ror.org/03kjjhe36 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210136522 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Tokyo Women's Medical University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Takuma Takada |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Cardiology, Tokyo Women's Medical University , Tokyo 1628666 , Japan |
| authorships[7].author.id | https://openalex.org/A5069343527 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-6659-4660 |
| authorships[7].author.display_name | Yoshito Ogihara |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I178574317 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , Tsu 5148507 , Japan |
| authorships[7].institutions[0].id | https://openalex.org/I178574317 |
| authorships[7].institutions[0].ror | https://ror.org/01529vy56 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I178574317 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Mie University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Yoshito Ogihara |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , Tsu 5148507 , Japan |
| authorships[8].author.id | https://openalex.org/A5031264446 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-3754-8593 |
| authorships[8].author.display_name | Tatsuya Nishikawa |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210151107 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Onco-Cardiology, Osaka International Cancer Institute , Osaka 5418567 , Japan |
| authorships[8].institutions[0].id | https://openalex.org/I4210151107 |
| authorships[8].institutions[0].ror | https://ror.org/05xvwhv53 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210151107 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Osaka International Cancer Institute |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Tatsuya Nishikawa |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Onco-Cardiology, Osaka International Cancer Institute , Osaka 5418567 , Japan |
| authorships[9].author.id | https://openalex.org/A5071751175 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-1615-3736 |
| authorships[9].author.display_name | Nobutaka Ikeda |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I129634264, https://openalex.org/I4210093329 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Cardiovascular Medicine, Toho University Ohashi Medical Center , Tokyo 1538515 , Japan |
| authorships[9].institutions[0].id | https://openalex.org/I129634264 |
| authorships[9].institutions[0].ror | https://ror.org/02hcx7n63 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I129634264 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Toho University |
| authorships[9].institutions[1].id | https://openalex.org/I4210093329 |
| authorships[9].institutions[1].ror | https://ror.org/00mre2126 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I4210093329 |
| authorships[9].institutions[1].country_code | JP |
| authorships[9].institutions[1].display_name | Toho University Ohashi Medical Center |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Nobutaka Ikeda |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Cardiovascular Medicine, Toho University Ohashi Medical Center , Tokyo 1538515 , Japan |
| authorships[10].author.id | https://openalex.org/A5012322656 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Kazunori Otsui |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I65837984 |
| authorships[10].affiliations[0].raw_affiliation_string | Department of General Internal Medicine, Kobe University Graduate School of Medicine , Kobe 6500017 , Japan |
| authorships[10].institutions[0].id | https://openalex.org/I65837984 |
| authorships[10].institutions[0].ror | https://ror.org/03tgsfw79 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I65837984 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Kobe University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Kazunori Otsui |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of General Internal Medicine, Kobe University Graduate School of Medicine , Kobe 6500017 , Japan |
| authorships[11].author.id | https://openalex.org/A5040221189 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-0960-0339 |
| authorships[11].author.display_name | Daisuke Sueta |
| authorships[11].countries | JP |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I96036126 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 8608556 , Japan |
| authorships[11].institutions[0].id | https://openalex.org/I96036126 |
| authorships[11].institutions[0].ror | https://ror.org/02cgss904 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I96036126 |
| authorships[11].institutions[0].country_code | JP |
| authorships[11].institutions[0].display_name | Kumamoto University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Daisuke Sueta |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , Kumamoto 8608556 , Japan |
| authorships[12].author.id | https://openalex.org/A5114172452 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Yukari Tsubata |
| authorships[12].countries | JP |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I169016828 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine , Izumo 6938501 , Japan |
| authorships[12].institutions[0].id | https://openalex.org/I169016828 |
| authorships[12].institutions[0].ror | https://ror.org/01jaaym28 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I169016828 |
| authorships[12].institutions[0].country_code | JP |
| authorships[12].institutions[0].display_name | Shimane University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Yukari Tsubata |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Department of Internal Medicine, Division of Medical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine , Izumo 6938501 , Japan |
| authorships[13].author.id | https://openalex.org/A5109952793 |
| authorships[13].author.orcid | |
| authorships[13].author.display_name | Masaaki Shoji |
| authorships[13].countries | JP |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210156366 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, National Cancer Center Hospital , Tokyo 1040045 , Japan |
| authorships[13].institutions[0].id | https://openalex.org/I4210156366 |
| authorships[13].institutions[0].ror | https://ror.org/05asn5035 |
| authorships[13].institutions[0].type | healthcare |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210137409, https://openalex.org/I4210156366 |
| authorships[13].institutions[0].country_code | JP |
| authorships[13].institutions[0].display_name | Tokyo National Hospital |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Masaaki Shoji |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Department of Cardiovascular Medicine, National Cancer Center Hospital , Tokyo 1040045 , Japan |
| authorships[14].author.id | https://openalex.org/A5071159806 |
| authorships[14].author.orcid | https://orcid.org/0000-0002-5633-1816 |
| authorships[14].author.display_name | Ayumi Shikama |
| authorships[14].countries | JP |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I146399215 |
| authorships[14].affiliations[0].raw_affiliation_string | Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba , Tsukuba 3058576 , Japan |
| authorships[14].institutions[0].id | https://openalex.org/I146399215 |
| authorships[14].institutions[0].ror | https://ror.org/02956yf07 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I146399215 |
| authorships[14].institutions[0].country_code | JP |
| authorships[14].institutions[0].display_name | University of Tsukuba |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Ayumi Shikama |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba , Tsukuba 3058576 , Japan |
| authorships[15].author.id | https://openalex.org/A5104161396 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Yutaka Hosoi |
| authorships[15].countries | JP |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I190930483 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Cardiovascular Surgery, Kyorin University Faculty of Medicine , Tokyo 1818611 , Japan |
| authorships[15].institutions[0].id | https://openalex.org/I190930483 |
| authorships[15].institutions[0].ror | https://ror.org/0188yz413 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I190930483 |
| authorships[15].institutions[0].country_code | JP |
| authorships[15].institutions[0].display_name | Kyorin University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Yutaka Hosoi |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Cardiovascular Surgery, Kyorin University Faculty of Medicine , Tokyo 1818611 , Japan |
| authorships[16].author.id | https://openalex.org/A5101521210 |
| authorships[16].author.orcid | https://orcid.org/0000-0001-8580-9404 |
| authorships[16].author.display_name | Yasuhiro Tanabe |
| authorships[16].countries | JP |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I163917720 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Cardiology, St Marianna University School of Medicine , Kawasaki 2168511 , Japan |
| authorships[16].institutions[0].id | https://openalex.org/I163917720 |
| authorships[16].institutions[0].ror | https://ror.org/043axf581 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I163917720 |
| authorships[16].institutions[0].country_code | JP |
| authorships[16].institutions[0].display_name | St. Marianna University School of Medicine |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Yasuhiro Tanabe |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Cardiology, St Marianna University School of Medicine , Kawasaki 2168511 , Japan |
| authorships[17].author.id | https://openalex.org/A5018410857 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-9115-2880 |
| authorships[17].author.display_name | Kengo Tsukahara |
| authorships[17].countries | JP |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I2799590887 |
| authorships[17].affiliations[0].raw_affiliation_string | Division of Cardiology, Fujisawa City Hospital , Fujisawa 2518550 , Japan |
| authorships[17].institutions[0].id | https://openalex.org/I2799590887 |
| authorships[17].institutions[0].ror | https://ror.org/04dd5bw95 |
| authorships[17].institutions[0].type | healthcare |
| authorships[17].institutions[0].lineage | https://openalex.org/I2799590887 |
| authorships[17].institutions[0].country_code | JP |
| authorships[17].institutions[0].display_name | Fujisawa City Hospital |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Kengo Tsukahara |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Division of Cardiology, Fujisawa City Hospital , Fujisawa 2518550 , Japan |
| authorships[18].author.id | https://openalex.org/A5054272000 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-3845-3542 |
| authorships[18].author.display_name | Naohiko Nakanishi |
| authorships[18].countries | JP |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I40677808 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto 6028566 , Japan |
| authorships[18].institutions[0].id | https://openalex.org/I40677808 |
| authorships[18].institutions[0].ror | https://ror.org/028vxwa22 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I40677808 |
| authorships[18].institutions[0].country_code | JP |
| authorships[18].institutions[0].display_name | Kyoto Prefectural University of Medicine |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Naohiko Nakanishi |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto 6028566 , Japan |
| authorships[19].author.id | https://openalex.org/A5100752287 |
| authorships[19].author.orcid | https://orcid.org/0000-0001-5751-5775 |
| authorships[19].author.display_name | Kitae Kim |
| authorships[19].countries | JP |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I4210161700 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital , Kobe 6500047 , Japan |
| authorships[19].institutions[0].id | https://openalex.org/I4210161700 |
| authorships[19].institutions[0].ror | https://ror.org/04j4nak57 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I4210161700 |
| authorships[19].institutions[0].country_code | JP |
| authorships[19].institutions[0].display_name | Kobe City Medical Center General Hospital |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Kitae Kim |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Department of Cardiovascular Medicine, Kobe City Medical Center General Hospital , Kobe 6500047 , Japan |
| authorships[20].author.id | https://openalex.org/A5010167438 |
| authorships[20].author.orcid | https://orcid.org/0000-0001-8163-8038 |
| authorships[20].author.display_name | Satoshi Ikeda |
| authorships[20].countries | JP |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I43777268 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki 8528501 , Japan |
| authorships[20].institutions[0].id | https://openalex.org/I43777268 |
| authorships[20].institutions[0].ror | https://ror.org/058h74p94 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I43777268 |
| authorships[20].institutions[0].country_code | JP |
| authorships[20].institutions[0].display_name | Nagasaki University |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Satoshi Ikeda |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki 8528501 , Japan |
| authorships[21].author.id | https://openalex.org/A5005695905 |
| authorships[21].author.orcid | |
| authorships[21].author.display_name | Kazunori Mushiake |
| authorships[21].countries | JP |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I4210089671 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[21].institutions[0].id | https://openalex.org/I4210089671 |
| authorships[21].institutions[0].ror | https://ror.org/00947s692 |
| authorships[21].institutions[0].type | healthcare |
| authorships[21].institutions[0].lineage | https://openalex.org/I4210089671 |
| authorships[21].institutions[0].country_code | JP |
| authorships[21].institutions[0].display_name | Kurashiki Central Hospital |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Kazunori Mushiake |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[22].author.id | https://openalex.org/A5073142509 |
| authorships[22].author.orcid | https://orcid.org/0000-0003-2845-9561 |
| authorships[22].author.display_name | Kazushige Kadota |
| authorships[22].countries | JP |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I4210089671 |
| authorships[22].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[22].institutions[0].id | https://openalex.org/I4210089671 |
| authorships[22].institutions[0].ror | https://ror.org/00947s692 |
| authorships[22].institutions[0].type | healthcare |
| authorships[22].institutions[0].lineage | https://openalex.org/I4210089671 |
| authorships[22].institutions[0].country_code | JP |
| authorships[22].institutions[0].display_name | Kurashiki Central Hospital |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Kazushige Kadota |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Department of Cardiovascular Medicine, Kurashiki Central Hospital , Kurashiki 7100052 , Japan |
| authorships[23].author.id | https://openalex.org/A5005311216 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-4163-980X |
| authorships[23].author.display_name | Koh Ono |
| authorships[23].countries | JP |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I22299242 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University , 54 Shogoin Kawahara-cho, Sakyo-ku, 6068507 Kyoto , Japan |
| authorships[23].institutions[0].id | https://openalex.org/I22299242 |
| authorships[23].institutions[0].ror | https://ror.org/02kpeqv85 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I22299242 |
| authorships[23].institutions[0].country_code | JP |
| authorships[23].institutions[0].display_name | Kyoto University |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Koh Ono |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University , 54 Shogoin Kawahara-cho, Sakyo-ku, 6068507 Kyoto , Japan |
| authorships[24].author.id | https://openalex.org/A5100668637 |
| authorships[24].author.orcid | https://orcid.org/0000-0002-5665-4076 |
| authorships[24].author.display_name | Takeshi Kimura |
| authorships[24].countries | JP |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I4210166362 |
| authorships[24].affiliations[0].raw_affiliation_string | Department of Cardiology, Hirakata Kohsai Hospital , Hirakata 5730153 , Japan |
| authorships[24].institutions[0].id | https://openalex.org/I4210166362 |
| authorships[24].institutions[0].ror | https://ror.org/05wvk1430 |
| authorships[24].institutions[0].type | healthcare |
| authorships[24].institutions[0].lineage | https://openalex.org/I4210166362 |
| authorships[24].institutions[0].country_code | JP |
| authorships[24].institutions[0].display_name | Municipal Hirakata City Hospital |
| authorships[24].author_position | last |
| authorships[24].raw_author_name | Takeshi Kimura |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Department of Cardiology, Hirakata Kohsai Hospital , Hirakata 5730153 , Japan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdf |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Edoxaban for 12 vs. 3 months in cancer-associated isolated distal deep vein thrombosis according to different doses: insights from the ONCO DVT study |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10285 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2724 |
| primary_topic.subfield.display_name | Internal Medicine |
| primary_topic.display_name | Venous Thromboembolism Diagnosis and Management |
| related_works | https://openalex.org/W2083469408, https://openalex.org/W2076023803, https://openalex.org/W4388598541, https://openalex.org/W1998982063, https://openalex.org/W2001030107, https://openalex.org/W2416657662, https://openalex.org/W2938840962, https://openalex.org/W2034648015, https://openalex.org/W3149604253, https://openalex.org/W2002145739 |
| cited_by_count | 5 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 4 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.1093/ehjcvp/pvae028 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2735768669 |
| best_oa_location.source.issn | 2055-6837, 2055-6845 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 2055-6837 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| best_oa_location.source.host_organization | https://openalex.org/P4310311648 |
| best_oa_location.source.host_organization_name | Oxford University Press |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| best_oa_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| best_oa_location.landing_page_url | https://doi.org/10.1093/ehjcvp/pvae028 |
| primary_location.id | doi:10.1093/ehjcvp/pvae028 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2735768669 |
| primary_location.source.issn | 2055-6837, 2055-6845 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 2055-6837 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| primary_location.source.host_organization | https://openalex.org/P4310311648 |
| primary_location.source.host_organization_name | Oxford University Press |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311648, https://openalex.org/P4310311647 |
| primary_location.source.host_organization_lineage_names | Oxford University Press, University of Oxford |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://academic.oup.com/ehjcvp/advance-article-pdf/doi/10.1093/ehjcvp/pvae028/57305145/pvae028.pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | European Heart Journal - Cardiovascular Pharmacotherapy |
| primary_location.landing_page_url | https://doi.org/10.1093/ehjcvp/pvae028 |
| publication_date | 2024-04-22 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4205182763, https://openalex.org/W4379285225, https://openalex.org/W4384923116, https://openalex.org/W3193235957, https://openalex.org/W3112865739, https://openalex.org/W3180022368, https://openalex.org/W4293217929, https://openalex.org/W4386209636, https://openalex.org/W2595086780, https://openalex.org/W2139785591, https://openalex.org/W4285087867, https://openalex.org/W4387117375, https://openalex.org/W2989714602, https://openalex.org/W2746088790, https://openalex.org/W4319341240, https://openalex.org/W2775434460, https://openalex.org/W3092570019, https://openalex.org/W3099163107, https://openalex.org/W4361000215, https://openalex.org/W4390505673, https://openalex.org/W4388694273, https://openalex.org/W4388091928, https://openalex.org/W2018856451 |
| referenced_works_count | 23 |
| abstract_inverted_index.= | 55, 67, 106, 124, 145, 175, 202, 216 |
| abstract_inverted_index.A | 219 |
| abstract_inverted_index.N | 54, 66 |
| abstract_inverted_index.P | 105, 123, 174, 201 |
| abstract_inverted_index.a | 48, 60, 141, 212, 232 |
| abstract_inverted_index.(P | 144, 215 |
| abstract_inverted_index.30 | 118, 194 |
| abstract_inverted_index.60 | 100, 167 |
| abstract_inverted_index.In | 31 |
| abstract_inverted_index.an | 258 |
| abstract_inverted_index.in | 91, 156, 161 |
| abstract_inverted_index.it | 183 |
| abstract_inverted_index.mg | 101, 119, 168, 195 |
| abstract_inverted_index.of | 9, 36, 84, 151, 251, 261 |
| abstract_inverted_index.to | 12, 231, 254 |
| abstract_inverted_index.we | 41 |
| abstract_inverted_index.(30 | 64 |
| abstract_inverted_index.(60 | 52 |
| abstract_inverted_index.12- | 76 |
| abstract_inverted_index.95% | 112, 128, 179, 206 |
| abstract_inverted_index.CI, | 129, 180, 207 |
| abstract_inverted_index.DVT | 4, 39, 227, 272 |
| abstract_inverted_index.OR, | 126, 177, 204 |
| abstract_inverted_index.The | 2, 80, 147 |
| abstract_inverted_index.and | 29, 57, 69, 77, 117 |
| abstract_inverted_index.did | 184 |
| abstract_inverted_index.due | 253 |
| abstract_inverted_index.for | 16, 74, 97, 165, 192, 223, 239, 247, 257 |
| abstract_inverted_index.not | 185 |
| abstract_inverted_index.the | 7, 25, 37, 43, 71, 75, 92, 99, 137, 157, 162, 166, 189, 193, 236, 240, 248, 255 |
| abstract_inverted_index.two | 190 |
| abstract_inverted_index.vs. | 103, 121, 172, 199 |
| abstract_inverted_index.was | 89, 134, 154, 211, 228, 245 |
| abstract_inverted_index.151) | 56 |
| abstract_inverted_index.450) | 68 |
| abstract_inverted_index.ONCO | 3, 38 |
| abstract_inverted_index.both | 98 |
| abstract_inverted_index.deep | 20 |
| abstract_inverted_index.dose | 51, 63, 250 |
| abstract_inverted_index.into | 45 |
| abstract_inverted_index.odds | 108 |
| abstract_inverted_index.risk | 260 |
| abstract_inverted_index.than | 94, 160 |
| abstract_inverted_index.this | 32 |
| abstract_inverted_index.vein | 21 |
| abstract_inverted_index.with | 47, 59, 263 |
| abstract_inverted_index.(1.1% | 120 |
| abstract_inverted_index.(1.3% | 102 |
| abstract_inverted_index.(8.7% | 198 |
| abstract_inverted_index.(DVT) | 23 |
| abstract_inverted_index.(ONCO | 271 |
| abstract_inverted_index.0.02; | 107 |
| abstract_inverted_index.0.12; | 111 |
| abstract_inverted_index.0.14; | 127 |
| abstract_inverted_index.0.89; | 203 |
| abstract_inverted_index.0.97; | 205 |
| abstract_inverted_index.3.61; | 178 |
| abstract_inverted_index.4.4%, | 173 |
| abstract_inverted_index.7.6%, | 122 |
| abstract_inverted_index.8.6%, | 200 |
| abstract_inverted_index.Trial | 267 |
| abstract_inverted_index.[CI], | 115 |
| abstract_inverted_index.[OR], | 110 |
| abstract_inverted_index.doses | 139, 238 |
| abstract_inverted_index.group | 96, 159, 164 |
| abstract_inverted_index.lower | 90 |
| abstract_inverted_index.major | 152 |
| abstract_inverted_index.ratio | 109 |
| abstract_inverted_index.risk. | 27, 242 |
| abstract_inverted_index.study | 5 |
| abstract_inverted_index.there | 210 |
| abstract_inverted_index.those | 46, 58 |
| abstract_inverted_index.which | 133 |
| abstract_inverted_index.(14.3% | 171 |
| abstract_inverted_index.0.002; | 125 |
| abstract_inverted_index.0.046; | 176 |
| abstract_inverted_index.0.07). | 217 |
| abstract_inverted_index.0.90). | 146 |
| abstract_inverted_index.11.6%, | 104 |
| abstract_inverted_index.across | 136, 235 |
| abstract_inverted_index.differ | 187 |
| abstract_inverted_index.distal | 19, 226 |
| abstract_inverted_index.groups | 191 |
| abstract_inverted_index.higher | 155 |
| abstract_inverted_index.number | 269 |
| abstract_inverted_index.study, | 40 |
| abstract_inverted_index.venous | 87 |
| abstract_inverted_index.3-month | 13, 78, 95, 163, 233 |
| abstract_inverted_index.Methods | 28 |
| abstract_inverted_index.Results | 30 |
| abstract_inverted_index.Trial): | 273 |
| abstract_inverted_index.between | 188 |
| abstract_inverted_index.caution | 244 |
| abstract_inverted_index.mg/day; | 53, 65 |
| abstract_inverted_index.reduced | 61 |
| abstract_inverted_index.regimen | 222 |
| abstract_inverted_index.whereas | 182 |
| abstract_inverted_index.without | 140 |
| abstract_inverted_index.12-month | 10, 82, 93, 148, 158, 220 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 243 |
| abstract_inverted_index.analysis | 35 |
| abstract_inverted_index.bleeding | 153, 262 |
| abstract_inverted_index.clinical | 72 |
| abstract_inverted_index.edoxaban | 14, 50, 62, 131, 138, 169, 196, 221, 237, 252 |
| abstract_inverted_index.interval | 114 |
| abstract_inverted_index.isolated | 18, 225 |
| abstract_inverted_index.outcomes | 73 |
| abstract_inverted_index.patients | 44 |
| abstract_inverted_index.regimen, | 234 |
| abstract_inverted_index.relative | 11 |
| abstract_inverted_index.revealed | 6 |
| abstract_inverted_index.standard | 49, 249 |
| abstract_inverted_index.subgroup | 34, 170, 197 |
| abstract_inverted_index.superior | 230 |
| abstract_inverted_index.therapy. | 266 |
| abstract_inverted_index.evaluated | 70 |
| abstract_inverted_index.incidence | 83, 150 |
| abstract_inverted_index.increased | 259 |
| abstract_inverted_index.potential | 213, 256 |
| abstract_inverted_index.prolonged | 264 |
| abstract_inverted_index.recurrent | 86 |
| abstract_inverted_index.regarding | 24 |
| abstract_inverted_index.suggested | 246 |
| abstract_inverted_index.treatment | 15 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.confidence | 113 |
| abstract_inverted_index.consistent | 135 |
| abstract_inverted_index.cumulative | 81, 149 |
| abstract_inverted_index.signalling | 209 |
| abstract_inverted_index.stratified | 42 |
| abstract_inverted_index.subgroups, | 132 |
| abstract_inverted_index.thrombosis | 22 |
| abstract_inverted_index.thrombotic | 26, 241 |
| abstract_inverted_index.Conclusions | 218 |
| abstract_inverted_index.NCT03895502 | 270 |
| abstract_inverted_index.interaction | 143, 214 |
| abstract_inverted_index.significant | 142 |
| abstract_inverted_index.superiority | 8 |
| abstract_inverted_index.symptomatic | 85 |
| abstract_inverted_index.treatments. | 79 |
| abstract_inverted_index.0.01–0.97) | 116 |
| abstract_inverted_index.0.03–0.60) | 130 |
| abstract_inverted_index.consistently | 229 |
| abstract_inverted_index.registration | 268 |
| abstract_inverted_index.0.49–1.91), | 208 |
| abstract_inverted_index.pre-specified | 33 |
| abstract_inverted_index.significantly | 186 |
| abstract_inverted_index.0.97–13.52), | 181 |
| abstract_inverted_index.anticoagulation | 265 |
| abstract_inverted_index.thromboembolism | 88 |
| abstract_inverted_index.cancer-associated | 17, 224 |
| abstract_inverted_index.https://classic.clinicaltrials.gov/ct2/show/NCT03895502 | 274 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 25 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8299999833106995 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.9232494 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |