Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart Study Article Swipe
Gloria Huei-Jong Graf
,
Allison E. Aiello
,
Avshalom Caspi
,
Meeraj Kothari
,
Hengyi Liu
,
Terrie E. Moffitt
,
Peter Muennig
,
Calen P. Ryan
,
Karen Sugden
,
Daniel W. Belsky
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.04.23298091
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.11.04.23298091
Importance People who complete more education live longer lives with better health. New evidence suggests that these benefits operate through a slowed pace of biological aging. If so, measurements of the pace biological aging could offer intermediate endpoints for studies of how interventions to promote education will impact healthy longevity. Objective To test the hypothesis that upward educational mobility contributes to a slower pace of biological aging and increased longevity. Design Prospective cohort study. Setting We analyzed data from three generations of participants in the Framingham Heart Study: the Original cohort, enrolled beginning in 1948, the Offspring cohort, enrolled beginning in 1971, and the Gen3 cohort, enrolled beginning in 2002. Follow-up is on-going. Data analysis was conducted during 2022-2023 using data obtained from dbGaP (phs000007.v33). Participants We constructed a three-generation database to quantify intergenerational educational mobility. We linked mobility data with blood DNA methylation data collected from the Offspring cohort in (2005-2008) (n=1,652) and the Gen3 cohort in 2009-2011 (n=1,449). These n=3,101 participants formed our analysis sample. Exposure We measured educational mobility by comparing participants’ educational outcomes with those of their parents. Outcomes We measured the pace of biological aging from whole-blood DNA-methylation data using the DunedinPACE epigenetic clock. For comparison purposes, we repeated analysis using four other epigenetic clocks. Survival follow-up was conducted through 2019. Results Participants who were upwardly mobile in educational terms tended to have slower DunedinPACE in later life (r=-0.18, 95% CI [-0.23,-0.13], p<0.001). This pattern of association was similar across generations and held in within-family sibling comparisons. 402 Offspring-cohort participants died over the follow-up period. Upward educational mobility was associated with lower mortality risk (HR=0.89, 95% CI [0.81,0.98] p=0.014). Slower DunedinPACE accounted for roughly half of this association. Conclusions and Relevance Our findings support the hypothesis that interventions to promote educational attainment will slow the pace of biological aging and promote longevity. Epigenetic clocks, like DunedinPACE, have potential as near-term outcome measures of intervention effects on healthy aging. Experimental evidence is needed to confirm findings.
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- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.11.04.23298091
- https://www.medrxiv.org/content/medrxiv/early/2023/11/05/2023.11.04.23298091.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4388377302
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4388377302Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.11.04.23298091Digital Object Identifier
- Title
-
Educational Mobility, the Pace of Biological Aging, and Lifespan in the Framingham Heart StudyWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-11-05Full publication date if available
- Authors
-
Gloria Huei-Jong Graf, Allison E. Aiello, Avshalom Caspi, Meeraj Kothari, Hengyi Liu, Terrie E. Moffitt, Peter Muennig, Calen P. Ryan, Karen Sugden, Daniel W. BelskyList of authors in order
- Landing page
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https://doi.org/10.1101/2023.11.04.23298091Publisher landing page
- PDF URL
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https://www.medrxiv.org/content/medrxiv/early/2023/11/05/2023.11.04.23298091.full.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.medrxiv.org/content/medrxiv/early/2023/11/05/2023.11.04.23298091.full.pdfDirect OA link when available
- Concepts
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Framingham Heart Study, Pace, Cohort, Offspring, Longevity, Cohort study, Gerontology, Prospective cohort study, Medicine, Framingham Risk Score, Demography, Psychology, Biology, Disease, Internal medicine, Pregnancy, Genetics, Geodesy, Sociology, GeographyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2024: 2Per-year citation counts (last 5 years)
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67Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.6035662 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |