Efeito da empagliflozina para além do controlo glicémico: benefício cardiovascular em doentes com DMT2 e doença cardiovascular estabelecida Article Swipe
Pedro Monteiro
,
Carlos Aguíar
,
Pedro Matos
,
José Silva‐Nunes
,
Rita Birne
,
Patrícia Branco
,
Joaquim Calado
,
Miguel Melo
,
Jorge Polónia
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1016/j.repc.2019.02.008
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1016/j.repc.2019.02.008
The prevalence of type 2 diabetes (T2D) continues to increase, and its association with cardiovascular (CV) disease has led to the inclusion of CV endpoints in clinical trials on the treatment of T2D. This article explores the various trials already performed and under development in this field, with particular focus on the EMPA-REG OUTCOME trial. In this trial, empagliflozin, a sodium-glucose co-transporter 2 inhibitor, demonstrated a reduction in CV risk in patients with T2D and established CV disease, in addition to CV safety and a decrease in glycated hemoglobin. This represents a paradigm shift that has led to changes in the international guidelines for the treatment of T2D. These results were maintained in subsequent subgroup analysis for heart failure, chronic kidney disease and peripheral arterial disease, although there are many questions concerning the mechanisms involved in these effects, including whether they are hemodynamic, metabolic or due to decreased myocardial cytoplasmic sodium concentrations. With this reduction in risk for major CV events in patients with T2D, the EMPA-REG OUTCOME trial demonstrated CV protection from a hypoglycemic drug for the first time, and opened a new era in the treatment and management of T2D. This study has led to the development of ongoing trials that will establish which patients will benefit most from this therapy, particularly with regard to comorbidities.
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Metadata
- Type
- review
- Language
- pt
- Landing Page
- https://doi.org/10.1016/j.repc.2019.02.008
- OA Status
- diamond
- Cited By
- 6
- References
- 57
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W2999132415Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.repc.2019.02.008Digital Object Identifier
- Title
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Efeito da empagliflozina para além do controlo glicémico: benefício cardiovascular em doentes com DMT2 e doença cardiovascular estabelecidaWork title
- Type
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reviewOpenAlex work type
- Language
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ptPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-10-01Full publication date if available
- Authors
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Pedro Monteiro, Carlos Aguíar, Pedro Matos, José Silva‐Nunes, Rita Birne, Patrícia Branco, Joaquim Calado, Miguel Melo, Jorge PolóniaList of authors in order
- Landing page
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https://doi.org/10.1016/j.repc.2019.02.008Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.repc.2019.02.008Direct OA link when available
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Medicine, EMPA, Gynecology, Chemistry, Electron microprobe, MineralogyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2024: 1, 2023: 3, 2022: 1, 2020: 1Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.effects, | 137 |
| abstract_inverted_index.explores | 35 |
| abstract_inverted_index.failure, | 118 |
| abstract_inverted_index.glycated | 87 |
| abstract_inverted_index.involved | 134 |
| abstract_inverted_index.paradigm | 92 |
| abstract_inverted_index.patients | 71, 162, 206 |
| abstract_inverted_index.subgroup | 114 |
| abstract_inverted_index.therapy, | 212 |
| abstract_inverted_index.continues | 7 |
| abstract_inverted_index.decreased | 147 |
| abstract_inverted_index.endpoints | 24 |
| abstract_inverted_index.establish | 204 |
| abstract_inverted_index.including | 138 |
| abstract_inverted_index.inclusion | 21 |
| abstract_inverted_index.increase, | 9 |
| abstract_inverted_index.metabolic | 143 |
| abstract_inverted_index.performed | 40 |
| abstract_inverted_index.questions | 130 |
| abstract_inverted_index.reduction | 66, 154 |
| abstract_inverted_index.treatment | 30, 105, 187 |
| abstract_inverted_index.concerning | 131 |
| abstract_inverted_index.guidelines | 102 |
| abstract_inverted_index.inhibitor, | 63 |
| abstract_inverted_index.maintained | 111 |
| abstract_inverted_index.management | 189 |
| abstract_inverted_index.mechanisms | 133 |
| abstract_inverted_index.myocardial | 148 |
| abstract_inverted_index.particular | 48 |
| abstract_inverted_index.peripheral | 123 |
| abstract_inverted_index.prevalence | 1 |
| abstract_inverted_index.protection | 171 |
| abstract_inverted_index.represents | 90 |
| abstract_inverted_index.subsequent | 113 |
| abstract_inverted_index.association | 12 |
| abstract_inverted_index.cytoplasmic | 149 |
| abstract_inverted_index.development | 43, 198 |
| abstract_inverted_index.established | 75 |
| abstract_inverted_index.hemoglobin. | 88 |
| abstract_inverted_index.demonstrated | 64, 169 |
| abstract_inverted_index.hemodynamic, | 142 |
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| abstract_inverted_index.empagliflozin, | 58 |
| abstract_inverted_index.sodium-glucose | 60 |
| abstract_inverted_index.concentrations. | 151 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5031874851 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I2802025818 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.65443 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |