Efeito da rutina em modelo de depressão crônico induzido por corticosterona em camundongos Article Swipe
Emanuel de Araújo Pinheiro
,
Leonardo de Sabóia Sousa
,
Alyne Alves da Silva
,
Carolina de Paiva Farias
,
Silvânia Maria Mendes Vasconcelos
,
José Eduardo Ribeiro Honório Júnior
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.12662/2317-3076jhbs.v6i2.1454.p145-151.2018
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.12662/2317-3076jhbs.v6i2.1454.p145-151.2018
Introdução: a depressão é uma doença altamente prevalente na população mundial e apesar de não ter sua causa estabelecida, algumas teorias tentam esclarecer sua etiologia. A rutina é um flavonoide pertencente à classe dos flavonóis, que tem propriedades anti-inflamatória e antioxidante. Objetivo: avaliar os efeitos antidepressivos da rutina em um modelo crônico induzido por corticosterona em camundongos. Metodologia: foram utilizados camundongos Swiss fêmeas (25-30g) que receberam corticosterona 20mg/kg ou tween 3% por 21dias. Outros grupos receberam corticosterona por 14 dias e entre 15o ao 21o dia de tratamento, rutina (0,2, 2,0 e 10mg/kg) ou fluoxetina10mg/kg ou diazepam 1mg/Kg. Uma hora após a última administração, os animais passaram pelos testes de campo aberto, labirinto em cruz elevada e nado forçado. Após os testes, os animais foram sacrificados por decapitação e as áreas cerebrais córtex pré-frontal, hipocampo e corpo estriado dissecados. Para análise entre os grupos foi usado o teste “t” de Student e para comparação múltipla dos parâmetros utilizará a Análise de Variância (ANOVA). Resultados: a corticosterona foi capaz de induzir a depressão nos animais. No teste de campo aberto, a rutina 0,2, 2,0 e 10mg/kg reduziram a locomoção. A menor dose da rutina apresentou melhor resposta, aumentando o número de entrada e tempo de permanência no braço aberto no teste de labirinto em cruz elevada. Também reduziu significativamente o tempo de imobilização no teste de nado forçado. Conclusão: a substância apresentou atividades ansiolítica e antidepressiva.
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- Type
- article
- Language
- pt
- Landing Page
- https://doi.org/10.12662/2317-3076jhbs.v6i2.1454.p145-151.2018
- https://periodicos.unichristus.edu.br/jhbs/article/download/1454/632
- OA Status
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- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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- DOI
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https://doi.org/10.12662/2317-3076jhbs.v6i2.1454.p145-151.2018Digital Object Identifier
- Title
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Efeito da rutina em modelo de depressão crônico induzido por corticosterona em camundongosWork title
- Type
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articleOpenAlex work type
- Language
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ptPrimary language
- Publication year
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2018Year of publication
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2018-04-02Full publication date if available
- Authors
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Emanuel de Araújo Pinheiro, Leonardo de Sabóia Sousa, Alyne Alves da Silva, Carolina de Paiva Farias, Silvânia Maria Mendes Vasconcelos, José Eduardo Ribeiro Honório JúniorList of authors in order
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https://doi.org/10.12662/2317-3076jhbs.v6i2.1454.p145-151.2018Publisher landing page
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https://periodicos.unichristus.edu.br/jhbs/article/download/1454/632Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://periodicos.unichristus.edu.br/jhbs/article/download/1454/632Direct OA link when available
- Concepts
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MedicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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