Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome Article Swipe

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Giorgio Gargari , Tomás Meroño , Gregorio Peron , Cristian Del Bo’ , Mirko Marino , Antonio Cherubini , Cristina Andrés‐Lacueva , Paul A. Kroon , Patrizia Riso , Simone Guglielmetti ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.20517/mrr.2025.33

Background: Aging may be associated with low-grade chronic inflammation (“inflammaging”) and gut microbiome alterations. Dietary polyphenols have been proposed as modulators of these processes. To explore the effects of a polyphenol-rich (PR) diet on inflammatory markers, gut microbiota, and metabolomic profiles in subjects aged ≥ 60 years stratified by baseline inflammation levels. Methods: In this post-hoc analysis of the MaPLE randomized crossover trial, 50 subjects aged ≥ 60 years were categorized into two subgroups: high inflammation (cH) and low inflammation (cL). Participants received a polyphenol-rich diet (PR-diet) or a control diet for 8 weeks, with a washout period in between. Fecal, blood, and urine samples were analyzed using shallow shotgun metagenomics and untargeted metabolomics. Results: The PR-diet was associated with a significant reduction in key inflammatory markers (e.g., IL-6, C-reactive protein) in the cH group. Distinct microbial shifts were observed, including an increase in Blautia and Dorea and a modest improvement in microbial diversity in cH subjects. Metabolomic analysis revealed group-specific changes, notably in polyphenol-derived metabolites. Conclusion: These findings suggest that polyphenol-rich diets may beneficially modulate inflammation and the gut microbial ecosystem in subjects aged ≥ 60 years with elevated baseline inflammation. Stratification by inflammatory status may improve the targeting and personalization of dietary interventions to support healthy aging.

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Type: article
Language: en
Landing Page: https://doi.org/10.20517/mrr.2025.33
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DOI: https://doi.org/10.20517/mrr.2025.33

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Title: Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome

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Publication year: 2025

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Authors: Giorgio Gargari, Tomás Meroño, Gregorio Peron, Cristian Del Bo’, Mirko Marino, Antonio Cherubini, Cristina Andrés‐Lacueva, Paul A. Kroon, Patrizia Riso, Simone Guglielmetti

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Landing page: https://doi.org/10.20517/mrr.2025.33

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