Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition, and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical Trial Article Swipe
Melissa M. Markofski
,
Kristofer Jennings
,
Kyle L. Timmerman
,
Jared M. Dickinson
,
Christopher S. Fry
,
Michael Borack
,
Paul T. Reidy
,
Rachel Deer
,
Amanda Randolph
,
Blake B. Rasmussen
,
Elena Volpi
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/gerona/gly109
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1093/gerona/gly109
Background Essential amino acids (EAA) and aerobic exercise (AE) acutely and independently stimulate skeletal muscle protein anabolism in older adults. Objective In this Phase 1, double-blind, placebo-controlled, randomized clinical trial, we determined if chronic EAA supplementation, AE training, or a combination of the two interventions could improve muscle mass and function by stimulating muscle protein synthesis. Methods We phone-screened 971, enrolled 109, and randomized 50 independent, low-active, nonfrail, and nondiabetic older adults (age 72 ± 1 years). We used a 2 × 2 factorial design. The interventions were: daily nutritional supplementation (15 g EAA or placebo) and physical activity (supervised AE training 3 days/week or monitored habitual activity) for 24 weeks. Muscle strength, physical function, body composition, and muscle protein synthesis were measured before and after the 24-week intervention. Results Forty-five subjects completed the 24-week intervention. VO2peak and walking speed increased (p < .05) in both AE groups, irrespective of supplementation type, but muscle strength increased only in the EAA + AE group (p < .05). EAA supplementation acutely increased (p < .05) muscle protein synthesis from basal both before and after the intervention, with a larger increase in the EAA + AE group after the intervention. Total and regional lean body mass did not change significantly with any intervention. Conclusions In nonfrail, independent, healthy older adults AE training increased walking speed and aerobic fitness, and, when combined with EAA supplementation, it also increased muscle strength and EAA-stimulated muscle protein synthesis. These increases occurred without improvements in muscle mass.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/gerona/gly109
- https://academic.oup.com/biomedgerontology/article-pdf/74/10/1598/30022756/gly109.pdf
- OA Status
- bronze
- Cited By
- 48
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2801069486
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2801069486Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1093/gerona/gly109Digital Object Identifier
- Title
-
Effect of Aerobic Exercise Training and Essential Amino Acid Supplementation for 24 Weeks on Physical Function, Body Composition, and Muscle Metabolism in Healthy, Independent Older Adults: A Randomized Clinical TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-05-10Full publication date if available
- Authors
-
Melissa M. Markofski, Kristofer Jennings, Kyle L. Timmerman, Jared M. Dickinson, Christopher S. Fry, Michael Borack, Paul T. Reidy, Rachel Deer, Amanda Randolph, Blake B. Rasmussen, Elena VolpiList of authors in order
- Landing page
-
https://doi.org/10.1093/gerona/gly109Publisher landing page
- PDF URL
-
https://academic.oup.com/biomedgerontology/article-pdf/74/10/1598/30022756/gly109.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://academic.oup.com/biomedgerontology/article-pdf/74/10/1598/30022756/gly109.pdfDirect OA link when available
- Concepts
-
Placebo, Aerobic exercise, Medicine, Randomized controlled trial, Lean body mass, Nutritional Supplementation, Internal medicine, Anabolism, Endocrinology, Skeletal muscle, Physical therapy, Sarcopenia, Body weight, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
48Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4, 2024: 6, 2023: 11, 2022: 3, 2021: 8Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.acids | 4 |
| abstract_inverted_index.after | 126, 182, 195 |
| abstract_inverted_index.amino | 3 |
| abstract_inverted_index.basal | 178 |
| abstract_inverted_index.could | 46 |
| abstract_inverted_index.daily | 89 |
| abstract_inverted_index.group | 163, 194 |
| abstract_inverted_index.mass. | 249 |
| abstract_inverted_index.older | 19, 71, 216 |
| abstract_inverted_index.speed | 140, 222 |
| abstract_inverted_index.type, | 152 |
| abstract_inverted_index.were: | 88 |
| abstract_inverted_index.Muscle | 112 |
| abstract_inverted_index.adults | 72, 217 |
| abstract_inverted_index.before | 124, 180 |
| abstract_inverted_index.change | 206 |
| abstract_inverted_index.larger | 187 |
| abstract_inverted_index.muscle | 15, 48, 54, 119, 154, 174, 235, 239, 248 |
| abstract_inverted_index.trial, | 30 |
| abstract_inverted_index.weeks. | 111 |
| abstract_inverted_index.24-week | 128, 135 |
| abstract_inverted_index.Methods | 57 |
| abstract_inverted_index.Results | 130 |
| abstract_inverted_index.VO2peak | 137 |
| abstract_inverted_index.acutely | 10, 169 |
| abstract_inverted_index.adults. | 20 |
| abstract_inverted_index.aerobic | 7, 224 |
| abstract_inverted_index.chronic | 34 |
| abstract_inverted_index.design. | 85 |
| abstract_inverted_index.groups, | 148 |
| abstract_inverted_index.healthy | 215 |
| abstract_inverted_index.improve | 47 |
| abstract_inverted_index.protein | 16, 55, 120, 175, 240 |
| abstract_inverted_index.walking | 139, 221 |
| abstract_inverted_index.without | 245 |
| abstract_inverted_index.years). | 77 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.activity | 99 |
| abstract_inverted_index.clinical | 29 |
| abstract_inverted_index.combined | 228 |
| abstract_inverted_index.enrolled | 61 |
| abstract_inverted_index.exercise | 8 |
| abstract_inverted_index.fitness, | 225 |
| abstract_inverted_index.function | 51 |
| abstract_inverted_index.habitual | 107 |
| abstract_inverted_index.increase | 188 |
| abstract_inverted_index.measured | 123 |
| abstract_inverted_index.occurred | 244 |
| abstract_inverted_index.physical | 98, 114 |
| abstract_inverted_index.placebo) | 96 |
| abstract_inverted_index.regional | 200 |
| abstract_inverted_index.skeletal | 14 |
| abstract_inverted_index.strength | 155, 236 |
| abstract_inverted_index.subjects | 132 |
| abstract_inverted_index.training | 102, 219 |
| abstract_inverted_index.Essential | 2 |
| abstract_inverted_index.Objective | 21 |
| abstract_inverted_index.activity) | 108 |
| abstract_inverted_index.anabolism | 17 |
| abstract_inverted_index.completed | 133 |
| abstract_inverted_index.days/week | 104 |
| abstract_inverted_index.factorial | 84 |
| abstract_inverted_index.function, | 115 |
| abstract_inverted_index.increased | 141, 156, 170, 220, 234 |
| abstract_inverted_index.increases | 243 |
| abstract_inverted_index.monitored | 106 |
| abstract_inverted_index.nonfrail, | 68, 213 |
| abstract_inverted_index.stimulate | 13 |
| abstract_inverted_index.strength, | 113 |
| abstract_inverted_index.synthesis | 121, 176 |
| abstract_inverted_index.training, | 38 |
| abstract_inverted_index.Background | 1 |
| abstract_inverted_index.Forty-five | 131 |
| abstract_inverted_index.determined | 32 |
| abstract_inverted_index.randomized | 28, 64 |
| abstract_inverted_index.synthesis. | 56, 241 |
| abstract_inverted_index.(supervised | 100 |
| abstract_inverted_index.Conclusions | 211 |
| abstract_inverted_index.combination | 41 |
| abstract_inverted_index.low-active, | 67 |
| abstract_inverted_index.nondiabetic | 70 |
| abstract_inverted_index.nutritional | 90 |
| abstract_inverted_index.stimulating | 53 |
| abstract_inverted_index.composition, | 117 |
| abstract_inverted_index.improvements | 246 |
| abstract_inverted_index.independent, | 66, 214 |
| abstract_inverted_index.irrespective | 149 |
| abstract_inverted_index.double-blind, | 26 |
| abstract_inverted_index.independently | 12 |
| abstract_inverted_index.intervention, | 184 |
| abstract_inverted_index.intervention. | 129, 136, 197, 210 |
| abstract_inverted_index.interventions | 45, 87 |
| abstract_inverted_index.significantly | 207 |
| abstract_inverted_index.EAA-stimulated | 238 |
| abstract_inverted_index.phone-screened | 59 |
| abstract_inverted_index.supplementation | 91, 151, 168 |
| abstract_inverted_index.supplementation, | 36, 231 |
| abstract_inverted_index.placebo-controlled, | 27 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5076259414, https://openalex.org/A5056820789, https://openalex.org/A5037897499, https://openalex.org/A5061883359, https://openalex.org/A5035050678, https://openalex.org/A5014318990 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I55302922 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.75 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.90672387 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |