Effect of altered production and storage of dopamine on development and behavior in C. elegans Article Swipe
Irene Lee
,
Ava C. Knickerbocker
,
Charlotte Rose Depew
,
Elizabeth L. Martin
,
Jocelyn Dicent
,
Gary W. Miller
,
Meghan L. Bucher
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/ftox.2024.1374866
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/ftox.2024.1374866
Introduction The nematode, Caenorhabditis elegans ( C. elegans ), is an advantageous model for studying developmental toxicology due to its well-defined developmental stages and homology to humans. It has been established that across species, dopaminergic neurons are highly vulnerable to neurotoxicant exposure, resulting in developmental neuronal dysfunction and age-induced degeneration. C. elegans , with genetic perturbations in dopamine system proteins, can provide insight into the mechanisms of dopaminergic neurotoxicants. In this study, we present a comprehensive analysis on the effect of gene mutations in dopamine-related proteins on body size, development, and behavior in C. elegans. Methods We studied C. elegans that lack the ability to sequester dopamine (OK411) and that overproduce dopamine (UA57) and a novel strain (MBIA) generated by the genetic crossing of OK411 and UA57, which both lack the ability to sequester dopamine into vesicles and, additionally, endogenously overproduce dopamine. The MBIA strain was generated to address the hypothesis that an endogenous increase in the production of dopamine can rescue deficits caused by a lack of vesicular dopamine sequestration. These strains were analyzed for body size, developmental stage, reproduction, egg laying, motor behaviors, and neuronal health utilizing multiple methods. Results Our results further implicate proper dopamine synthesis and sequestration in the regulation of C. elegans body size, development through larval stages into gravid adulthood, and motor functioning. Furthermore, our analyses demonstrate that body size in terms of length is distinct from the developmental stage as fully developed gravid adult C. elegans with disruptions in the dopamine system have decreased body lengths. Thus, body size should not be used as a proxy for the developmental stage when designing experiments. Discussion Our results provide additional evidence that the dopamine system impacts the development, growth, and reproduction in C. elegans . Furthermore, our data suggest that endogenously increasing the production of dopamine mitigates deficits in C. elegans lacking the ability to package dopamine into synaptic vesicles. The novel strain, MBIA, and novel analyses of development and reproduction presented here can be utilized in developmental neurotoxicity experiments.
Related Topics
Concepts
Dopamine
Caenorhabditis elegans
Dopaminergic
Biology
Mushroom bodies
Dopamine transporter
Phenotype
Oxidopamine
Motor coordination
Gene
Neuroscience
Cell biology
Genetics
Drosophila melanogaster
Substantia nigra
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/ftox.2024.1374866
- OA Status
- gold
- Cited By
- 3
- References
- 50
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401638970
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401638970Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/ftox.2024.1374866Digital Object Identifier
- Title
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Effect of altered production and storage of dopamine on development and behavior in C. elegansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-08-16Full publication date if available
- Authors
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Irene Lee, Ava C. Knickerbocker, Charlotte Rose Depew, Elizabeth L. Martin, Jocelyn Dicent, Gary W. Miller, Meghan L. BucherList of authors in order
- Landing page
-
https://doi.org/10.3389/ftox.2024.1374866Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/ftox.2024.1374866Direct OA link when available
- Concepts
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Dopamine, Caenorhabditis elegans, Dopaminergic, Biology, Mushroom bodies, Dopamine transporter, Phenotype, Oxidopamine, Motor coordination, Gene, Neuroscience, Cell biology, Genetics, Drosophila melanogaster, Substantia nigraTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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