Effect of Anesthetics on Functional Connectivity of Developing Brain Article Swipe
Xu Chen
,
Xuemei Zheng
,
Jianghui Cai
,
Xiao Yang
,
Yonghong Lin
,
Mengjun Wu
,
Xiaofan Deng
,
Yong Peng
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnhum.2022.853816
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fnhum.2022.853816
The potential anesthetic neurotoxicity on the neonate is an important focus of research investigation in the field of pediatric anesthesiology. It is essential to understand how these anesthetics may affect the development and growth of neonatal immature and vulnerable brains. Functional magnetic resonance imaging (fMRI) has suggested that using anesthetics result in reduced functional connectivity may consider as core sequence for the neurotoxicity and neurodegenerative changes in the developed brain. Anesthetics either directly impact the primary structures and functions of the brain or indirectly alter the hemodynamic parameters that contribute to cerebral blood flow (CBF) in neonatal patients. We hypothesis that anesthetic agents may either decrease the brain functional connectivity in neonatal patients or animals, which was observed by fMRI. This review will summarize the effect and mechanism of anesthesia on the rapid growth and development infant and neonate brain with fMRI through functional connectivity. It is possible to provide the new mechanism of neuronal injury induced by anesthetics and objective imaging evidence in animal developing brain.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnhum.2022.853816
- https://www.frontiersin.org/articles/10.3389/fnhum.2022.853816/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 108
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221031949
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4221031949Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnhum.2022.853816Digital Object Identifier
- Title
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Effect of Anesthetics on Functional Connectivity of Developing BrainWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-03-11Full publication date if available
- Authors
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Xu Chen, Xuemei Zheng, Jianghui Cai, Xiao Yang, Yonghong Lin, Mengjun Wu, Xiaofan Deng, Yong PengList of authors in order
- Landing page
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https://doi.org/10.3389/fnhum.2022.853816Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fnhum.2022.853816/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fnhum.2022.853816/pdfDirect OA link when available
- Concepts
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Neuroscience, Anesthetic, Neurotoxicity, Medicine, Functional magnetic resonance imaging, Mechanism (biology), Cerebral blood flow, Functional connectivity, Anesthesia, Psychology, Internal medicine, Toxicity, Philosophy, EpistemologyTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 3, 2022: 1Per-year citation counts (last 5 years)
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108Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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