Effect of bladder filling volume on detrusor contractility in men with bladder outlet obstruction Article Swipe
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· 2022
· Open Access
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· DOI: https://doi.org/10.1002/nau.25113
Introduction Bladder outlet obstruction alters detrusor contractility, reducing the bladder ' s ability to respond to large filling with a risk of urinary retention. The objective was to assess the effect of bladder filling volume on detrusor contractility in men with bladder outlet obstruction. Methods A prospective multicenter study in two pelviperineology departments. Male patients eligible for urodynamics (IPSS score > 7) were included from January to July 2022. In case of absence of bladder outlet obstruction on pressure‐flow studies, they were secondarily excluded. The primary endpoint was the maximum isometric detrusor pressure during a stop‐test, corresponding to detrusor contractility, measured at 3 filling volumes (50%, 75%, and 100% of cystometric capacity). Results Fifty‐two patients performed urodynamics, of whom 12 were excluded because of lack of obstruction or inability to perform the stop‐test. Detrusor contractility was significantly higher for a 75% bladder filling than 50% and for a 75% filling than 100%, with a mean difference of 19.5; confidence interval (CI) 95% [14.3; 24.8] and 12.2; CI 95% [6.9; 17.5] cmH 2 O respectively ( p < 0,01). Conclusion In case of bladder outlet obstruction in men, detrusor contractility depends on bladder filling volume, with reduced contractility when the bladder was underfilled or overfilled. This phenomenon could help to explain the mechanisms of urinary retention in men with bladder outlet obstruction.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/nau.25113
- OA Status
- hybrid
- Cited By
- 7
- References
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- Related Works
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- OpenAlex ID
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Raw OpenAlex JSON
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https://openalex.org/W4311577703Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/nau.25113Digital Object Identifier
- Title
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Effect of bladder filling volume on detrusor contractility in men with bladder outlet obstructionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
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2022Year of publication
- Publication date
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2022-12-15Full publication date if available
- Authors
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Nicolas Hermieu, C. Chesnel, Maëlys Teng, Évanguelos Xylinas, I. Ouzaïd, Jean‐François Hermieu, G. Amarenco, Claire HentzenList of authors in order
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https://doi.org/10.1002/nau.25113Publisher landing page
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1002/nau.25113Direct OA link when available
- Concepts
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Medicine, Bladder outlet obstruction, Urology, Contractility, Volume (thermodynamics), Internal medicine, Quantum mechanics, Physics, Prostate, CancerTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 4, 2024: 2, 2022: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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