Effect of bone marrow mononuclear cells therapy on long-term survival of patients with liver cirrhosis: A 10-year retrospective cohort study using propensity score matching Article Swipe
Mengfan Ruan
,
Yuhang Yin
,
Ning Wen
,
Beilei Zhang
,
Hao Lin
,
Huiying Yu
,
Xiaoxi Wang
,
Dehui Zou
,
Xiaodong Shao
,
Jiang Chen
,
Hongyu Li
,
Xiaozhong Guo
,
Xingshun Qi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/jtim-2025-0044
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/jtim-2025-0044
Background Bone marrow mononuclear cells (BMMNCs) therapy should be effective for the improvement of liver function and short-term outcome in patients with liver cirrhosis, but few studies have explored the long-term prognosis of cirrhotic patients treated with BMMNCs. Methods In this retrospective study, eligible patients with liver cirrhosis were selected by using propensity score matching (PSM). Effect of BMMNCs on death was explored by Cox regression analysis, as well as competing risk analysis, where liver transplantation was a competing event. Hazard ratio (HR) and sub-distribution HR (sHR) were calculated. Subgroup analyses were performed based on the age, sex, Child-Pugh class, and model for end-stage liver disease (MELD) score. Results Overall, 260 patients were included, of whom 130 were treated with transhepatic arterial transplantation of BMMNCs. The median follow-up duration was 5.27 (range: 0.37–16.62) years. By adjusting by age, sex, and Child-Pugh score, multivariate Cox regression (HR = 0.707, P = 0.020) and competing risk analyses (sHR = 0.709, P = 0.026) demonstrated that BMMNCs were independently associated with a lower risk of death in cirrhotic patients in the overall analysis. Univariate Cox regression analyses demonstrated that BMMNCs were significantly associated with a decreased risk of death in the subgroup analyses of age ≤50 years (HR= 0.533, P = 0.016), male (HR = 0.626, P = 0.010), Child-Pugh class B (HR = 0.638, P = 0.026), and MELD score > 12 (HR = 0.483, P = 0.002), but not age > 50 years ( P = 0.097), female ( P = 0.170), Child-Pugh class A ( P = 0.309), Child-Pugh class C ( P = 0.369), or MELD score ≤12 ( P = 0.096). Conclusion BMMNCs can provide additional survival benefits in patients with liver cirrhosis.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/jtim-2025-0044
- https://www.degruyterbrill.com/document/doi/10.1515/jtim-2025-0044/pdf
- OA Status
- hybrid
- References
- 67
- OpenAlex ID
- https://openalex.org/W4415545907
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4415545907Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1515/jtim-2025-0044Digital Object Identifier
- Title
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Effect of bone marrow mononuclear cells therapy on long-term survival of patients with liver cirrhosis: A 10-year retrospective cohort study using propensity score matchingWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-10-01Full publication date if available
- Authors
-
Mengfan Ruan, Yuhang Yin, Ning Wen, Beilei Zhang, Hao Lin, Huiying Yu, Xiaoxi Wang, Dehui Zou, Xiaodong Shao, Jiang Chen, Hongyu Li, Xiaozhong Guo, Xingshun QiList of authors in order
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https://doi.org/10.1515/jtim-2025-0044Publisher landing page
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https://www.degruyterbrill.com/document/doi/10.1515/jtim-2025-0044/pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.degruyterbrill.com/document/doi/10.1515/jtim-2025-0044/pdfDirect OA link when available
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0Total citation count in OpenAlex
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