Effect of Chronic Tibolone Administration on Memory and Choline Acetyltransferase and Tryptophan Hydroxylase Content in Aging Mice Article Swipe
Tzayaka Castillo-Mendieta
,
Guadalupe Bautista-Poblet
,
Angélica Coyoy-Salgado
,
Emily L. Castillo-García
,
Rodolfo Pinto‐Almazán
,
Claudia Erika Fuentes‐Venado
,
Teresa Neri-Gómez
,
Christian Guerra‐Araiza
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci14090903
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci14090903
Gonadal steroids exert different effects on the central nervous system (CNS), such as preserving neuronal function and promoting neuronal survival. Estradiol, progesterone, and testosterone reduce neuronal loss in the CNS in animal models of neurodegeneration. However, hormone replacement therapy has been associated with higher rates of endometrial, prostate, and breast cancer. Tibolone (TIB), the metabolites of which show estrogenic and progestogenic effects, is an alternative to reduce this risk. However, the impact of TIB on memory and learning, as well as on choline acetyltransferase (ChAT) and tryptophan hydroxylase (TPH) levels in the hippocampus of aging males, is unknown. We administered TIB to aged C57BL/6J male mice at different doses (0.01 or 1.0 mg/kg per day for 12 weeks) and evaluated its effects on memory and learning and the content of ChAT and TPH. We assessed memory and learning with object recognition and elevated T-maze tasks. Additionally, we determined ChAT and TPH protein levels in the hippocampus by Western blotting. TIB administration increased the percentage of time spent on the novel object in the object recognition task. In addition, the latency of leaving the enclosed arm increased in both TIB groups, suggesting an improvement in fear-based learning. We also observed decreased ChAT content in the group treated with the 0.01 mg/kg TIB dose. In the case of TPH, no changes were observed with either TIB dose. These results show that long-term TIB administration improves memory without affecting locomotor activity and modulates cholinergic but not serotonergic systems in the hippocampus of aged male mice.
Related Topics
Concepts
Choline acetyltransferase
Tibolone
Internal medicine
Endocrinology
Morris water navigation task
Tryptophan hydroxylase
Hippocampus
Serotonergic
Ovariectomized rat
Medicine
Serotonin
Cholinergic
Psychology
Hormone
Chemistry
Estrogen
Receptor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/brainsci14090903
- OA Status
- gold
- Cited By
- 1
- References
- 98
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4402314018
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4402314018Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/brainsci14090903Digital Object Identifier
- Title
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Effect of Chronic Tibolone Administration on Memory and Choline Acetyltransferase and Tryptophan Hydroxylase Content in Aging MiceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-09-06Full publication date if available
- Authors
-
Tzayaka Castillo-Mendieta, Guadalupe Bautista-Poblet, Angélica Coyoy-Salgado, Emily L. Castillo-García, Rodolfo Pinto‐Almazán, Claudia Erika Fuentes‐Venado, Teresa Neri-Gómez, Christian Guerra‐AraizaList of authors in order
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https://doi.org/10.3390/brainsci14090903Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.3390/brainsci14090903Direct OA link when available
- Concepts
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Choline acetyltransferase, Tibolone, Internal medicine, Endocrinology, Morris water navigation task, Tryptophan hydroxylase, Hippocampus, Serotonergic, Ovariectomized rat, Medicine, Serotonin, Cholinergic, Psychology, Hormone, Chemistry, Estrogen, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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98Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.aged | 102, 249 |
| abstract_inverted_index.also | 197 |
| abstract_inverted_index.been | 40 |
| abstract_inverted_index.both | 187 |
| abstract_inverted_index.case | 214 |
| abstract_inverted_index.loss | 26 |
| abstract_inverted_index.male | 104, 250 |
| abstract_inverted_index.mice | 105 |
| abstract_inverted_index.show | 57, 227 |
| abstract_inverted_index.such | 11 |
| abstract_inverted_index.that | 228 |
| abstract_inverted_index.this | 67 |
| abstract_inverted_index.time | 165 |
| abstract_inverted_index.well | 79 |
| abstract_inverted_index.were | 219 |
| abstract_inverted_index.with | 42, 138, 206, 221 |
| abstract_inverted_index.(0.01 | 109 |
| abstract_inverted_index.(TPH) | 88 |
| abstract_inverted_index.These | 225 |
| abstract_inverted_index.aging | 94 |
| abstract_inverted_index.dose. | 211, 224 |
| abstract_inverted_index.doses | 108 |
| abstract_inverted_index.exert | 2 |
| abstract_inverted_index.group | 204 |
| abstract_inverted_index.mg/kg | 112, 209 |
| abstract_inverted_index.mice. | 251 |
| abstract_inverted_index.novel | 169 |
| abstract_inverted_index.rates | 44 |
| abstract_inverted_index.risk. | 68 |
| abstract_inverted_index.spent | 166 |
| abstract_inverted_index.task. | 175 |
| abstract_inverted_index.which | 56 |
| abstract_inverted_index.(CNS), | 10 |
| abstract_inverted_index.(ChAT) | 84 |
| abstract_inverted_index.(TIB), | 52 |
| abstract_inverted_index.T-maze | 143 |
| abstract_inverted_index.animal | 31 |
| abstract_inverted_index.breast | 49 |
| abstract_inverted_index.either | 222 |
| abstract_inverted_index.higher | 43 |
| abstract_inverted_index.impact | 71 |
| abstract_inverted_index.levels | 89, 152 |
| abstract_inverted_index.males, | 95 |
| abstract_inverted_index.memory | 75, 123, 135, 233 |
| abstract_inverted_index.models | 32 |
| abstract_inverted_index.object | 139, 170, 173 |
| abstract_inverted_index.reduce | 24, 66 |
| abstract_inverted_index.system | 9 |
| abstract_inverted_index.tasks. | 144 |
| abstract_inverted_index.weeks) | 117 |
| abstract_inverted_index.Gonadal | 0 |
| abstract_inverted_index.Western | 157 |
| abstract_inverted_index.cancer. | 50 |
| abstract_inverted_index.central | 7 |
| abstract_inverted_index.changes | 218 |
| abstract_inverted_index.choline | 82 |
| abstract_inverted_index.content | 128, 201 |
| abstract_inverted_index.effects | 4, 121 |
| abstract_inverted_index.groups, | 189 |
| abstract_inverted_index.hormone | 36 |
| abstract_inverted_index.latency | 179 |
| abstract_inverted_index.leaving | 181 |
| abstract_inverted_index.nervous | 8 |
| abstract_inverted_index.protein | 151 |
| abstract_inverted_index.results | 226 |
| abstract_inverted_index.systems | 244 |
| abstract_inverted_index.therapy | 38 |
| abstract_inverted_index.treated | 205 |
| abstract_inverted_index.without | 234 |
| abstract_inverted_index.C57BL/6J | 103 |
| abstract_inverted_index.However, | 35, 69 |
| abstract_inverted_index.Tibolone | 51 |
| abstract_inverted_index.activity | 237 |
| abstract_inverted_index.assessed | 134 |
| abstract_inverted_index.effects, | 61 |
| abstract_inverted_index.elevated | 142 |
| abstract_inverted_index.enclosed | 183 |
| abstract_inverted_index.function | 15 |
| abstract_inverted_index.improves | 232 |
| abstract_inverted_index.learning | 125, 137 |
| abstract_inverted_index.neuronal | 14, 18, 25 |
| abstract_inverted_index.observed | 198, 220 |
| abstract_inverted_index.steroids | 1 |
| abstract_inverted_index.unknown. | 97 |
| abstract_inverted_index.addition, | 177 |
| abstract_inverted_index.affecting | 235 |
| abstract_inverted_index.blotting. | 158 |
| abstract_inverted_index.decreased | 199 |
| abstract_inverted_index.different | 3, 107 |
| abstract_inverted_index.evaluated | 119 |
| abstract_inverted_index.increased | 161, 185 |
| abstract_inverted_index.learning, | 77 |
| abstract_inverted_index.learning. | 195 |
| abstract_inverted_index.locomotor | 236 |
| abstract_inverted_index.long-term | 229 |
| abstract_inverted_index.modulates | 239 |
| abstract_inverted_index.promoting | 17 |
| abstract_inverted_index.prostate, | 47 |
| abstract_inverted_index.survival. | 19 |
| abstract_inverted_index.Estradiol, | 20 |
| abstract_inverted_index.associated | 41 |
| abstract_inverted_index.determined | 147 |
| abstract_inverted_index.estrogenic | 58 |
| abstract_inverted_index.fear-based | 194 |
| abstract_inverted_index.percentage | 163 |
| abstract_inverted_index.preserving | 13 |
| abstract_inverted_index.suggesting | 190 |
| abstract_inverted_index.tryptophan | 86 |
| abstract_inverted_index.alternative | 64 |
| abstract_inverted_index.cholinergic | 240 |
| abstract_inverted_index.hippocampus | 92, 155, 247 |
| abstract_inverted_index.hydroxylase | 87 |
| abstract_inverted_index.improvement | 192 |
| abstract_inverted_index.metabolites | 54 |
| abstract_inverted_index.recognition | 140, 174 |
| abstract_inverted_index.replacement | 37 |
| abstract_inverted_index.administered | 99 |
| abstract_inverted_index.endometrial, | 46 |
| abstract_inverted_index.serotonergic | 243 |
| abstract_inverted_index.testosterone | 23 |
| abstract_inverted_index.Additionally, | 145 |
| abstract_inverted_index.progesterone, | 21 |
| abstract_inverted_index.progestogenic | 60 |
| abstract_inverted_index.administration | 160, 231 |
| abstract_inverted_index.acetyltransferase | 83 |
| abstract_inverted_index.neurodegeneration. | 34 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.76229427 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |