Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papilla Article Swipe
Hamed Karkehabadi
,
Afsaneh Rahmati
,
Roshanak Abbasi
,
Abbas Farmany
,
Rezvan Najafi
,
Rooholah Behroozi
,
Loghman Rezaei-Soufi
,
Hadiseh Abbaspourrokni
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12903-023-02916-0
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1186/s12903-023-02916-0
Objectives This experimental study aimed to assess the effect of copper oxide nanoparticles (CuONPs) and light-emitting diode (LED) irradiation on the cell viability and osteogenic/odontogenic differentiation of human SCAPs. Methods After the culture of SCAPs, the effects of different concentrations of CuONPs on cell viability were evaluated by the methyl thiazolyl tetrazolium (MTT) assay after 24 and 48 h, and the optimal concentration was determined ( n = 12). SCAPs were then divided into four groups based on the type of treatment: (I) no-treatment control group, (II) exposure to CuONPs, (III) LED irradiation (635 nm, 200 mW/cm 2 ) for 30 s, and (IV) exposure to CuONPs combined with LED irradiation. CuONPs were synthesized by a green technique, which was based on reduction and simultaneous stability of copper ions by using the pomegranate peel extract. After treatments, the expression of osteogenic/odontogenic markers including dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP), alkaline phosphatase (ALP), and dentin matrix acidic phosphoprotein 1 (DMP1) was evaluated in all four groups using quantitative real-time polymerase chain reaction (PCR) ( n = 16). Also, osteogenic differentiation of SCAPs was evaluated qualitatively by alizarin red staining (ARS) to assess the matrix mineralization ( n = 4). SPSS version 18 was used for data evaluation. The Kruskal–Wallis and Mann–Whitney tests were used to compare the groups. Results Exposure to 1 µg/mL CuONPs resulted in maximum viability of SCAPs. Concentrations of CuONPs over 10 µg/mL significantly decreased the viability of SCAPs. Real-time PCR showed that the expression of DMP1, BSP, ALP, and DSPP in CuONPs + LED and LED groups was significantly higher than that in CuONPs and control groups at both 24 and 48 h ( P < 0.05). The density of ARS increased in all experimental groups after 24 h, and in CuONPs + LED and CuONPs groups after 48 h, compared to the control group. Conclusion Addition of CuONPs and LED irradiation of SCAPs in the culture medium significantly enhanced their osteogenic/odontogenic differentiation.
Related Topics
Concepts
Viability assay
Dentin sialophosphoprotein
Alkaline phosphatase
Osteocalcin
Andrology
MTT assay
Nuclear chemistry
Medicine
Molecular biology
Chemistry
Apoptosis
Biology
Biochemistry
Enzyme
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s12903-023-02916-0
- https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-023-02916-0
- OA Status
- gold
- Cited By
- 14
- References
- 55
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4367308571
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4367308571Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s12903-023-02916-0Digital Object Identifier
- Title
-
Effect of copper oxide nanoparticles and light-emitting diode irradiation on the cell viability and osteogenic/odontogenic differentiation of human stem cells from the apical papillaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-04-28Full publication date if available
- Authors
-
Hamed Karkehabadi, Afsaneh Rahmati, Roshanak Abbasi, Abbas Farmany, Rezvan Najafi, Rooholah Behroozi, Loghman Rezaei-Soufi, Hadiseh AbbaspourrokniList of authors in order
- Landing page
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https://doi.org/10.1186/s12903-023-02916-0Publisher landing page
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https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-023-02916-0Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://bmcoralhealth.biomedcentral.com/counter/pdf/10.1186/s12903-023-02916-0Direct OA link when available
- Concepts
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Viability assay, Dentin sialophosphoprotein, Alkaline phosphatase, Osteocalcin, Andrology, MTT assay, Nuclear chemistry, Medicine, Molecular biology, Chemistry, Apoptosis, Biology, Biochemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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14Total citation count in OpenAlex
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2025: 6, 2024: 4, 2023: 4Per-year citation counts (last 5 years)
- References (count)
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55Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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