Effect of Doxycycline in Decreasing the Severity of Clostridioides difficile Infection in Mice Article Swipe
Bo‐Yang Tsai
,
Yi‐Hsin Lai
,
Chun-Wei Chiu
,
Chih‐Yu Hsu
,
Yi‐Hsuan Chen
,
Yueh-Lin Chen
,
Pei-Jane Tsai
,
Yuan‐Pin Hung
,
Wen‐Chien Ko
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics11010116
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/antibiotics11010116
Background: Doxycycline possesses antibacterial activity against Clostridioides difficile and anti-inflammatory effects. Materials and Methods: The influence of doxycycline on the development of CDI was studied in an established animal model of CDI using C57BL/6 mice. Results: Mice intraperitoneally administered doxycycline had higher cecum weight (1.3 ± 0.1 vs. 0.5 ± 0.1 g; p < 0.001) and less body weight reduction (0.7 ± 0.5 g vs. −17.4 ± 0.2 g; p < 0.001) than untreated mice infected with C. difficile. Oral doxycycline, metronidazole, or vancomycin therapy resulted in less body weight reduction in mice with CDI than in untreated mice (1.1 ± 0.1 g, 1.3 ± 0.2 g, 1.2 ± 0.1 g, vs. 2.9 ± 0.3 g; p < 0.001). Doxycycline therapy led to lower expression levels of inflammatory cytokines, such as macrophage inflammatory protein-2 (0.4 ± 0.1 vs. 2.9 ± 1.3, p = 0.02), and higher levels of zonula occludens-1 (1.2 ± 0.1 vs. 0.8 ± 0.1, p = 0.02) in colonic tissues than in untreated mice. Conclusions: Concurrent intraperitoneal administration of doxycycline and oral C. difficile challenge does not aggravate the disease severity of CDI, and oral doxycycline may be a potential therapeutic option for CDI.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/antibiotics11010116
- https://www.mdpi.com/2079-6382/11/1/116/pdf?version=1642407063
- OA Status
- gold
- Cited By
- 2
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4205668606
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4205668606Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/antibiotics11010116Digital Object Identifier
- Title
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Effect of Doxycycline in Decreasing the Severity of Clostridioides difficile Infection in MiceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-17Full publication date if available
- Authors
-
Bo‐Yang Tsai, Yi‐Hsin Lai, Chun-Wei Chiu, Chih‐Yu Hsu, Yi‐Hsuan Chen, Yueh-Lin Chen, Pei-Jane Tsai, Yuan‐Pin Hung, Wen‐Chien KoList of authors in order
- Landing page
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https://doi.org/10.3390/antibiotics11010116Publisher landing page
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https://www.mdpi.com/2079-6382/11/1/116/pdf?version=1642407063Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2079-6382/11/1/116/pdf?version=1642407063Direct OA link when available
- Concepts
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Doxycycline, Medicine, Metronidazole, Cecum, Internal medicine, Pharmacology, Clostridioides, Gastroenterology, Antibiotics, Microbiology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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42Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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