doi.org
Effect of Doxycycline in Decreasing the Severity of Clostridioides difficile Infection in Mice
January 2022 • Bo‐Yang Tsai, Yi‐Hsin Lai, Chun-Wei Chiu, Chih‐Yu Hsu, Yi‐Hsuan Chen, Yueh-Lin Chen, Pei-Jane Tsai, Yuan‐Pin Hung, Wen‐Chien Ko
Background: Doxycycline possesses antibacterial activity against Clostridioides difficile and anti-inflammatory effects. Materials and Methods: The influence of doxycycline on the development of CDI was studied in an established animal model of CDI using C57BL/6 mice. Results: Mice intraperitoneally administered doxycycline had higher cecum weight (1.3 ± 0.1 vs. 0.5 ± 0.1 g; p < 0.001) and less body weight reduction (0.7 ± 0.5 g vs. −17.4 ± 0.2 g; p < 0.001) than untreated mice infected with C. difficile. Or…