Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover Study Article Swipe
Cibele Cristine Berto Marques da Silva
,
Simone Dal Corso
,
Adriana Cláudia Lunardi
,
Alfredo José da Fonseca
,
Samia Zahi Rached
,
Rodrigo Abensur Athanazio
,
Celso Ricardo Fernandes Carvalho
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2196/68582
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2196/68582
Background Bronchodilators (BDs) have been used therapeutically to improve exercise capacity in patients with other chronic respiratory diseases. However, the effect of BDs on the exercise capacity of individuals with non-cystic fibrosis bronchiectasis (NCFB) is poorly understood. Objective The aim of this study was to evaluate the effects of BDs on exercise capacity and thoracoabdominal kinematics in patients with NCFB. Methods This crossover randomized controlled trial will involve 45 outpatients with NCFB aged 18 to 59 years. They will be evaluated in 3 visits. On day 1, the maximal exercise capacity (cardiopulmonary exercise test; peak work rate [Wpeak]) will be assessed. On day 2, individuals will be randomized to receive either BD (ipratropium bromide 160 µg and fenoterol hydrobromide 400 µg) or a placebo and then undergo simultaneous endurance exercise capacity (constant work-rate exercise test) and thoracoabdominal kinematics (optoelectronic plethysmography) assessments. After at least 1-week washout (day 3), the individuals will repeat the same assessments as on day 2 in the reverse order. The time to the limit of tolerance will be obtained in both groups (BD and placebo groups) as the primary outcome. Thoracoabdominal kinematics will be assessed at 3 time points: at rest, during unloaded exercise, and at 75% Wpeak. The total chest wall and compartmental volumes as well as thoracoabdominal asynchrony will be assessed. The assessors and patients will be blinded to the interventions (BDs or placebo). Data will be compared using 1-sided t tests or Wilcoxon tests and repeated-measures analysis of variance or Friedman tests. Categorical data will be analyzed using the chi-square test or Fisher test. The associations among variables will be analyzed using Pearson or Spearman correlation. The significance level will be set at 5% (P<.05). Results The ethics approval was granted in November 2018, and a pilot study was commenced in April 2019 but was interrupted due to the COVID-19 pandemic. The study restarted in April 2022, and data collection is anticipated to continue until November 2025. The publication of the results is anticipated to be in 2025 or 2026. Conclusions There is no evidence that BDs can improve the exercise capacity of patients with NCFB. This trial will compare the endurance exercise capacity of the same individual with and without dual bronchodilation. If successful, this study will demonstrate that exercise capacity can be improved with the use of BDs in adults with NCFB. Trial Registration ClinicalTrials.gov NCT05183841; https://clinicaltrials.gov/study/NCT05183841 International Registered Report Identifier (IRRID) DERR1-10.2196/68582
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2196/68582
- OA Status
- gold
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410874032
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410874032Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.2196/68582Digital Object Identifier
- Title
-
Effect of Dual Bronchodilation on the Exercise Capacity of Individuals With Non-Cystic Fibrosis Bronchiectasis: Protocol for a Randomized Controlled Double-Blind Crossover StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-05-30Full publication date if available
- Authors
-
Cibele Cristine Berto Marques da Silva, Simone Dal Corso, Adriana Cláudia Lunardi, Alfredo José da Fonseca, Samia Zahi Rached, Rodrigo Abensur Athanazio, Celso Ricardo Fernandes CarvalhoList of authors in order
- Landing page
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https://doi.org/10.2196/68582Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.2196/68582Direct OA link when available
- Concepts
-
Preprint, Cystic fibrosis, Randomized controlled trial, Medicine, Double blind, Physical therapy, Protocol (science), Bronchodilation, Physical medicine and rehabilitation, Psychology, Placebo, Computer science, Internal medicine, Alternative medicine, Pathology, World Wide Web, Asthma, BronchodilatorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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39Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.tests | 237, 240 |
| abstract_inverted_index.total | 203 |
| abstract_inverted_index.trial | 65, 354 |
| abstract_inverted_index.until | 321 |
| abstract_inverted_index.using | 234, 254, 268 |
| abstract_inverted_index.(NCFB) | 33 |
| abstract_inverted_index.1-week | 144 |
| abstract_inverted_index.Fisher | 259 |
| abstract_inverted_index.Report | 398 |
| abstract_inverted_index.Wpeak. | 201 |
| abstract_inverted_index.adults | 388 |
| abstract_inverted_index.during | 195 |
| abstract_inverted_index.effect | 20 |
| abstract_inverted_index.either | 110 |
| abstract_inverted_index.ethics | 284 |
| abstract_inverted_index.groups | 175 |
| abstract_inverted_index.order. | 162 |
| abstract_inverted_index.poorly | 35 |
| abstract_inverted_index.repeat | 151 |
| abstract_inverted_index.tests. | 248 |
| abstract_inverted_index.years. | 76 |
| abstract_inverted_index.(IRRID) | 400 |
| abstract_inverted_index.1-sided | 235 |
| abstract_inverted_index.Methods | 60 |
| abstract_inverted_index.Pearson | 269 |
| abstract_inverted_index.Results | 282 |
| abstract_inverted_index.blinded | 223 |
| abstract_inverted_index.bromide | 113 |
| abstract_inverted_index.chronic | 15 |
| abstract_inverted_index.compare | 356 |
| abstract_inverted_index.effects | 47 |
| abstract_inverted_index.granted | 287 |
| abstract_inverted_index.groups) | 179 |
| abstract_inverted_index.improve | 8, 345 |
| abstract_inverted_index.involve | 67 |
| abstract_inverted_index.maximal | 88 |
| abstract_inverted_index.placebo | 123, 178 |
| abstract_inverted_index.points: | 192 |
| abstract_inverted_index.primary | 182 |
| abstract_inverted_index.receive | 109 |
| abstract_inverted_index.results | 328 |
| abstract_inverted_index.reverse | 161 |
| abstract_inverted_index.undergo | 126 |
| abstract_inverted_index.visits. | 83 |
| abstract_inverted_index.volumes | 208 |
| abstract_inverted_index.washout | 145 |
| abstract_inverted_index.without | 367 |
| abstract_inverted_index.COVID-19 | 306 |
| abstract_inverted_index.Friedman | 247 |
| abstract_inverted_index.However, | 18 |
| abstract_inverted_index.November | 289, 322 |
| abstract_inverted_index.Spearman | 271 |
| abstract_inverted_index.Wilcoxon | 239 |
| abstract_inverted_index.[Wpeak]) | 97 |
| abstract_inverted_index.analysis | 243 |
| abstract_inverted_index.analyzed | 253, 267 |
| abstract_inverted_index.approval | 285 |
| abstract_inverted_index.assessed | 188 |
| abstract_inverted_index.capacity | 10, 26, 52, 90, 130, 348, 360, 378 |
| abstract_inverted_index.compared | 233 |
| abstract_inverted_index.continue | 320 |
| abstract_inverted_index.evaluate | 45 |
| abstract_inverted_index.evidence | 341 |
| abstract_inverted_index.exercise | 9, 25, 51, 89, 92, 129, 133, 347, 359, 377 |
| abstract_inverted_index.fibrosis | 31 |
| abstract_inverted_index.improved | 381 |
| abstract_inverted_index.obtained | 172 |
| abstract_inverted_index.outcome. | 183 |
| abstract_inverted_index.patients | 12, 57, 220, 350 |
| abstract_inverted_index.unloaded | 196 |
| abstract_inverted_index.variance | 245 |
| abstract_inverted_index.(constant | 131 |
| abstract_inverted_index.Objective | 37 |
| abstract_inverted_index.assessed. | 100, 216 |
| abstract_inverted_index.assessors | 218 |
| abstract_inverted_index.commenced | 296 |
| abstract_inverted_index.crossover | 62 |
| abstract_inverted_index.diseases. | 17 |
| abstract_inverted_index.endurance | 128, 358 |
| abstract_inverted_index.evaluated | 80 |
| abstract_inverted_index.exercise, | 197 |
| abstract_inverted_index.fenoterol | 117 |
| abstract_inverted_index.pandemic. | 307 |
| abstract_inverted_index.placebo). | 229 |
| abstract_inverted_index.restarted | 310 |
| abstract_inverted_index.tolerance | 169 |
| abstract_inverted_index.variables | 264 |
| abstract_inverted_index.work-rate | 132 |
| abstract_inverted_index.Background | 0 |
| abstract_inverted_index.Identifier | 399 |
| abstract_inverted_index.Registered | 397 |
| abstract_inverted_index.asynchrony | 213 |
| abstract_inverted_index.chi-square | 256 |
| abstract_inverted_index.collection | 316 |
| abstract_inverted_index.controlled | 64 |
| abstract_inverted_index.individual | 364 |
| abstract_inverted_index.kinematics | 55, 137, 185 |
| abstract_inverted_index.non-cystic | 30 |
| abstract_inverted_index.randomized | 63, 107 |
| abstract_inverted_index.(P<.05). | 281 |
| abstract_inverted_index.Categorical | 249 |
| abstract_inverted_index.Conclusions | 337 |
| abstract_inverted_index.anticipated | 318, 330 |
| abstract_inverted_index.assessments | 154 |
| abstract_inverted_index.demonstrate | 375 |
| abstract_inverted_index.individuals | 28, 104, 149 |
| abstract_inverted_index.interrupted | 302 |
| abstract_inverted_index.outpatients | 69 |
| abstract_inverted_index.publication | 325 |
| abstract_inverted_index.respiratory | 16 |
| abstract_inverted_index.successful, | 371 |
| abstract_inverted_index.understood. | 36 |
| abstract_inverted_index.(ipratropium | 112 |
| abstract_inverted_index.NCT05183841; | 394 |
| abstract_inverted_index.Registration | 392 |
| abstract_inverted_index.assessments. | 140 |
| abstract_inverted_index.associations | 262 |
| abstract_inverted_index.correlation. | 272 |
| abstract_inverted_index.hydrobromide | 118 |
| abstract_inverted_index.significance | 274 |
| abstract_inverted_index.simultaneous | 127 |
| abstract_inverted_index.International | 396 |
| abstract_inverted_index.compartmental | 207 |
| abstract_inverted_index.interventions | 226 |
| abstract_inverted_index.bronchiectasis | 32 |
| abstract_inverted_index.(optoelectronic | 138 |
| abstract_inverted_index.Bronchodilators | 1 |
| abstract_inverted_index.therapeutically | 6 |
| abstract_inverted_index.(cardiopulmonary | 91 |
| abstract_inverted_index.Thoracoabdominal | 184 |
| abstract_inverted_index.bronchodilation. | 369 |
| abstract_inverted_index.plethysmography) | 139 |
| abstract_inverted_index.thoracoabdominal | 54, 136, 212 |
| abstract_inverted_index.repeated-measures | 242 |
| abstract_inverted_index.ClinicalTrials.gov | 393 |
| abstract_inverted_index.DERR1-10.2196/68582 | 401 |
| abstract_inverted_index.https://clinicaltrials.gov/study/NCT05183841 | 395 |
| cited_by_percentile_year | |
| countries_distinct_count | 2 |
| institutions_distinct_count | 7 |
| citation_normalized_percentile.value | 0.30668943 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |