Effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease: A prospective observational study Article Swipe
Nils Dennhardt
,
Frederike‐Debora Elfgen‐Schiffner
,
Oliver Keil
,
Christiane E. Beck
,
Sebastian Heiderich
,
Robert Sümpelmann
,
Katja Nickel
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/pan.13977
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/pan.13977
Background Neonates and infants with congenital heart disease undergoing general anesthesia have an increased risk for critical cardiovascular events. Etomidate produces very minimal changes in hemodynamic parameters in older children with congenital heart disease. There is a lack of studies evaluating the effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease. Aim The aim of this prospective observational study was to evaluate the effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease. Methods In fifty infants aged 0‐11 months (24% neonates n = 12) with congenital heart disease, mean arterial blood pressure, cardiac index using electrical cardiometry, and regional cerebral oxygen saturation using near‐infrared spectroscopy were measured at baseline and 1, 3, 5, and 10 minutes after induction by 0.4 mg kg −1 etomidate. Hypotension was defined as a mean arterial blood pressure under 35 mm Hg and cerebral desaturation as a regional cerebral oxygen saturation of less than 80% of baseline. Results Mean arterial blood pressure, cardiac index, and regional cerebral oxygen saturation remained stable above the predefined limits. Mean arterial blood pressure decreased slightly within a physiological range after 3 minutes ( P = .005, 95% CI:‐5.9 to −1.0). No significant change in cardiac index could be observed. Conclusion Etomidate 0.4mg kg −1 does not impair systemic or regional cerebral perfusion in neonates or infants with congenital heart disease.
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Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/pan.13977
- OA Status
- hybrid
- Cited By
- 2
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3044319391
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3044319391Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/pan.13977Digital Object Identifier
- Title
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Effect of etomidate on systemic and regional cerebral perfusion in neonates and infants with congenital heart disease: A prospective observational studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-07-24Full publication date if available
- Authors
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Nils Dennhardt, Frederike‐Debora Elfgen‐Schiffner, Oliver Keil, Christiane E. Beck, Sebastian Heiderich, Robert Sümpelmann, Katja NickelList of authors in order
- Landing page
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https://doi.org/10.1111/pan.13977Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1111/pan.13977Direct OA link when available
- Concepts
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Etomidate, Medicine, Cerebral perfusion pressure, Anesthesia, Heart disease, Blood pressure, Cardiology, Hemodynamics, Internal medicine, Mean arterial pressure, Heart rate, Cerebral blood flow, PropofolTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2024: 2Per-year citation counts (last 5 years)
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30Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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