Effect of experimental stress on the small bowel and colon in healthy humans Article Swipe
Susan E. Pritchard
,
Klara Garsed
,
Caroline L. Hoad
,
Melanie Lingaya
,
Rawinder Banwait
,
W. Thongborisute
,
Emma Roberts
,
Carolyn Costigan
,
Luca Marciani
,
Penny Gowland
,
Robert E. Spiller
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/nmo.12529
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/nmo.12529
Background Symptoms of irritable bowel syndrome ( IBS ) are frequently reported to be exacerbated by stress. Animal studies suggest that corticotrophin releasing hormone ( CRH ) mediates the effect of stress on the bowel. We have shown that stressed IBS patients with diarrhea have constricted small bowels. We hypothesized that we could mimic this effect by applying experimental stress in the form of either hand immersion in ice water or CRH injection in healthy volunteers ( HV ). Methods The postprandial effect of the cold pressor test (repeated hand immersion in ice cold water) and injection of CRH , were assessed vs control in two groups of 18 HV s. Key Results CRH produced a significant rise from baseline salivary cortisol levels ( p = 0.004) not seen with the cold pressor test. Small bowel water content ( SBWC ) fell postprandially on all four treatments. SBWC was significantly reduced by both stressors but CRH caused a greater effect ( anova, p < 0.003 vs p = 0.02). Ascending colon ( AC ) volume was greater after CRH injection compared with saline ( p = 0.002) but no differences were seen with the cold pressor test vs warm water. Postprandial increase in colon volume was also reduced by CRH which also increased the sensations of distension and bloating. Conclusions & Inferences Two experimental stressors were shown to constrict the small bowel, mimicking the effect previously seen in IBS ‐D patients. CRH increased the volume of the AC . We speculate that stress accelerates transfer of water from the small bowel to the AC .
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/nmo.12529
- OA Status
- hybrid
- Cited By
- 25
- References
- 31
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2069830007
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2069830007Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/nmo.12529Digital Object Identifier
- Title
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Effect of experimental stress on the small bowel and colon in healthy humansWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
-
2015-02-20Full publication date if available
- Authors
-
Susan E. Pritchard, Klara Garsed, Caroline L. Hoad, Melanie Lingaya, Rawinder Banwait, W. Thongborisute, Emma Roberts, Carolyn Costigan, Luca Marciani, Penny Gowland, Robert E. SpillerList of authors in order
- Landing page
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https://doi.org/10.1111/nmo.12529Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1111/nmo.12529Direct OA link when available
- Concepts
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Postprandial, Irritable bowel syndrome, Internal medicine, Medicine, Bloating, Saline, Corticotropin-releasing hormone, Endocrinology, Distension, Cold pressor test, Defecation, Diarrhea, Hormone, Heart rate, Blood pressure, InsulinTop concepts (fields/topics) attached by OpenAlex
- Cited by
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25Total citation count in OpenAlex
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2024: 1, 2023: 1, 2022: 1, 2021: 2, 2020: 2Per-year citation counts (last 5 years)
- References (count)
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31Number of works referenced by this work
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-
10Other works algorithmically related by OpenAlex
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