Effect of intensity-modulated radiation therapy on sciatic nerve injury caused by echinococcosis Article Swipe
Wanlong Xu
,
Dilimulati Aikeremu
,
Jungang Sun
,
Yanjun Zhang
,
Jiangbo Xu
,
Wenzheng Zhou
,
Xi-Bin Zhao
,
Hao Wang
,
Hong Yuan
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4103/1673-5374.293153
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.4103/1673-5374.293153
Conventional radiotherapy has a good killing effect on femoral echinococcosis. However, the sciatic nerve around the lesion is irreversibly damaged owing to bystander effects. Although intensity-modulated radiation therapy shows great advantages for precise dose distribution into lesions, it is unknown whether intensity-modulated radiation therapy can perfectly protect the surrounding sciatic nerve on the basis of good killing of femoral echinococcosis foci. Therefore, this study comparatively analyzed differences between intensity-modulated radiation therapy and conventional radiotherapy on the basis of safety to peripheral nerves. Pure-breed Meriones meridiani with bilateral femoral echinococcosis were selected as the research object. Intensity-modulated radiation therapy was used to treat left femoral echinococcosis of Meriones meridianus, while conventional radiotherapy was used to treat right femoral echinococcosis of the same Meriones meridianus. The total radiation dose was 40 Gy. To understand whether intensity-modulated radiation therapy and conventional radiotherapy can kill femoral echinococcosis, trypan blue staining was used to detect pathological changes of bone Echinococcus granulosus and protoscolex death after radiotherapy. Additionally, enzyme histochemical staining was utilized to measure acid phosphatase activity in the protoscolex after radiotherapy. One week after radiotherapy, the overall structure of echinococcosis in bilateral femurs of Meriones meridiani treated by intensity-modulated radiation therapy disappeared. There was no significant difference in the mortality rate of protoscoleces of Echinococcus granulosus between the bilateral femurs of Meriones meridiani. Moreover, there was no significant difference in acid phosphatase activity in the protoscolex of Echinococcus granulosus between bilateral femurs. To understand the injury of sciatic nerve surrounding the foci of femoral echinococcosis caused by intensity-modulated radiation therapy and conventional radiotherapy, the ultrastructure of sciatic nerves after radiotherapy was observed by transmission electron microscopy. Additionally, apoptosis of neurons was examined using a terminal-deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and expression of Bcl-2 and Bax in sciatic nerve tissue was detected by immunohistochemical staining and western blot assay. Our results showed that most neurons in the left sciatic nerve of Meriones meridiani with echinococcosis treated by intensity-modulated radiation therapy had reversible injury, and there was no obvious apoptosis. Compared with conventional radiotherapy, the number of apoptotic cells and Bax expression in sciatic nerve treated by intensity-modulated radiation therapy were significantly decreased, while Bcl-2 expression was significantly increased. Our findings suggest that intensity-modulated radiation therapy has the same therapeutic effect on echinococcosis as conventional radiotherapy, and can reduce apoptosis of the sciatic nerve around foci caused by radiotherapy. Experiments were approved by the Animal Ethics Committee of People's Hospital of Xinjiang Uygur Autonomous Region, China (Approval No. 20130301A41) on March 1, 2013.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/1673-5374.293153
- OA Status
- gold
- Cited By
- 9
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3087994871
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3087994871Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.4103/1673-5374.293153Digital Object Identifier
- Title
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Effect of intensity-modulated radiation therapy on sciatic nerve injury caused by echinococcosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
-
2020-09-23Full publication date if available
- Authors
-
Wanlong Xu, Dilimulati Aikeremu, Jungang Sun, Yanjun Zhang, Jiangbo Xu, Wenzheng Zhou, Xi-Bin Zhao, Hao Wang, Hong YuanList of authors in order
- Landing page
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https://doi.org/10.4103/1673-5374.293153Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4103/1673-5374.293153Direct OA link when available
- Concepts
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Medicine, Radiation therapy, Echinococcosis, Echinococcus granulosus, Femur, Sciatic nerve, Pathology, Radiology, Anatomy, Surgery, Biology, ZoologyTop concepts (fields/topics) attached by OpenAlex
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9Total citation count in OpenAlex
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2024: 2, 2023: 1, 2022: 3, 2021: 3Per-year citation counts (last 5 years)
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43Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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