Effect of interleukin‐17 on periodontitis development: An instrumental variable analysis Article Swipe
Sebastian‐Edgar Baumeister
,
Birte Holtfreter
,
Stefan Lars Reckelkamm
,
Daniel Hagenfeld
,
Thomas Kocher
,
Zoheir Alayash
,
Benjamin Ehmke
,
Hansjörg Baurecht
,
Michael Nolde
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/jper.22-0365
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/jper.22-0365
Background Circulating levels of interleukin‐17 (IL‐17) are associated with the presence and severity of periodontitis. However, whether IL‐17 is causal for disease development is unknown. We investigated the effect of genetically proxied IL‐17 on periodontitis using instrumental variable analysis. Methods We identified 12 genetic variants from genome‐wide association study (GWAS) of 7760 European descent individuals, used these variants as instrumental variables for IL‐17, and linked them to a GWAS of 17,353 clinical periodontitis cases and 28,210 European controls. Generalized weighted least squares analysis accounted for linkage disequilibrium of variants. Results We found an inverse association of genetically proxied IL‐17 and periodontitis (odds ratio, 0.84; 95% confidence interval: 0.75‒0.94; p = 0.003), which was corroborated after sensitivity analysis for horizontal pleiotropy. Conclusion The findings suggest that IL‐17 protects against initial periodontitis.
Related Topics
Concepts
Periodontitis
Linkage disequilibrium
Odds ratio
Genome-wide association study
Instrumental variable
Genetic association
Medicine
Pleiotropy
Confidence interval
Internal medicine
Genetics
Haplotype
Biology
Allele
Genotype
Mathematics
Statistics
Single-nucleotide polymorphism
Gene
Phenotype
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jper.22-0365
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.22-0365
- OA Status
- hybrid
- Cited By
- 5
- References
- 36
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4315754584
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4315754584Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jper.22-0365Digital Object Identifier
- Title
-
Effect of interleukin‐17 on periodontitis development: An instrumental variable analysisWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-01-12Full publication date if available
- Authors
-
Sebastian‐Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Daniel Hagenfeld, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjörg Baurecht, Michael NoldeList of authors in order
- Landing page
-
https://doi.org/10.1002/jper.22-0365Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.22-0365Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/JPER.22-0365Direct OA link when available
- Concepts
-
Periodontitis, Linkage disequilibrium, Odds ratio, Genome-wide association study, Instrumental variable, Genetic association, Medicine, Pleiotropy, Confidence interval, Internal medicine, Genetics, Haplotype, Biology, Allele, Genotype, Mathematics, Statistics, Single-nucleotide polymorphism, Gene, PhenotypeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
36Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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