Effect of long-term frozen storage on stability of kappa free light chain index Article Swipe
Martin Schmidauer
,
Klaus Berek
,
Gabriel Bsteh
,
Michael Auer
,
Robert Barket
,
Franziska Di Pauli
,
Michaela Hassler
,
Dejan Milosajevic
,
Anne Zinganell
,
Janette Walde
,
Florian Deisenhammer
,
Harald Hegen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2025-0125
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1515/cclm-2025-0125
Objectives To investigate whether frozen storage duration influences κ-FLC index. Methods CSF and serum samples of patients with multiple sclerosis collected for routine diagnostic purposes had been stored at −20 °C. κ-FLC and albumin concentrations were measured at two different timepoints, i.e. before and after storage. The κ-FLC index was calculated as (CSF κ-FLC/serum κ-FLC)/(CSF albumin/serum albumin). Results A total of 70 patients were included showing median CSF κ-FLC concentration of 0.25 (25th-75th percentile: 0.12–0.43) mg/dL, serum κ-FLC concentration of 1.05 (0.86–1.34) mg/dL, CSF albumin concentration of 17.7 (14.6–26.1) mg/dL and serum albumin concentration of 4230 (3898–4488) mg/dL. The κ-FLC index was 44 (25–108). With increasing frozen storage duration, the absolute concentrations of CSF κ-FLC, serum κ-FLC, CSF albumin and serum albumin decreased, while the κ-FLC index remained stable. The observed changes in absolute concentrations evened out by using CSF/serum ratios of κ-FLC and albumin when calculating the κ-FLC index. Conclusions Frozen storage at −20 °C has no relevant impact on κ-FLC index.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1515/cclm-2025-0125
- https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0125/pdf
- OA Status
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- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://openalex.org/W4410742171Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1515/cclm-2025-0125Digital Object Identifier
- Title
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Effect of long-term frozen storage on stability of kappa free light chain indexWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
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2025-05-08Full publication date if available
- Authors
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Martin Schmidauer, Klaus Berek, Gabriel Bsteh, Michael Auer, Robert Barket, Franziska Di Pauli, Michaela Hassler, Dejan Milosajevic, Anne Zinganell, Janette Walde, Florian Deisenhammer, Harald HegenList of authors in order
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https://doi.org/10.1515/cclm-2025-0125Publisher landing page
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https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0125/pdfDirect link to full text PDF
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hybridOpen access status per OpenAlex
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https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0125/pdfDirect OA link when available
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Albumin, Chemistry, Chromatography, Serum albumin, Percentile, Biochemistry, Mathematics, StatisticsTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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