Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior Article Swipe
Mako Kobayashi
,
Masako Ohara
,
Yoshihide Hashimoto
,
Naoko Nakamura
,
Toshiya Fujisato
,
Tsuyoshi Kimura
,
Akio Kishida
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.01.18.427096
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1101/2021.01.18.427096
As the number of cardiovascular diseases increases, artificial heart valves and blood vessels have been developed. Although cardiovascular application using decellularized tissue have been studied, the mechanism of their functionality is still unknown. To find the important factor for preparing decellularized cardiovascular prothesis which shows good in vivo performance, the effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior was investigated. Various luminal surface structures of decellularized aorta were prepared by heating, drying and peeling. The luminal surface structure and collagen denaturation was evaluated by immunohistological staining, collagen hybridizing peptide (CHP) staining and scanning electron microscopy (SEM) analysis. To evaluate the effect of luminal surface structure of decellularized aorta on thrombus formation and cell behavior, blood clotting test and recellularization of endothelial cells and smooth muscular cells were performed. The results of blood clotting test showed that the closer the luminal surface structure is to native aorta, the higher the anti-coagulant property. From the result of cell seeding-test, it was suggested that vascular cells recognize the luminal surface structure and regulate adhesion, proliferation and functional expression. These results will provide important factor for preparing decellularized cardiovascular prothesis and lead to future development on decellularized cardiovascular applications.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2021.01.18.427096
- https://www.biorxiv.org/content/biorxiv/early/2021/01/18/2021.01.18.427096.full.pdf
- OA Status
- green
- Cited By
- 4
- References
- 20
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3124381642
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3124381642Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2021.01.18.427096Digital Object Identifier
- Title
-
Effect of luminal surface structure of decellularized aorta on thrombus formation and cell behaviorWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-18Full publication date if available
- Authors
-
Mako Kobayashi, Masako Ohara, Yoshihide Hashimoto, Naoko Nakamura, Toshiya Fujisato, Tsuyoshi Kimura, Akio KishidaList of authors in order
- Landing page
-
https://doi.org/10.1101/2021.01.18.427096Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/01/18/2021.01.18.427096.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2021/01/18/2021.01.18.427096.full.pdfDirect OA link when available
- Concepts
-
Decellularization, Thrombus, Aorta, Thrombogenicity, Adhesion, Cell adhesion, Biomedical engineering, Cell, Chemistry, Fibronectin, Blood vessel, Extracellular matrix, Cell biology, Biophysics, Medicine, Internal medicine, Biology, Biochemistry, Thrombosis, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2022: 4Per-year citation counts (last 5 years)
- References (count)
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20Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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