Effect of mitomycin-C on corneal endothelial cell parameters after refractive surface ablation procedures Article Swipe
Hossein Mohammad-Rabei
,
Raheleh Moravej
,
Mina Almasi‐Nasrabadi
,
Parisa Rezazadeh
,
Navid Manafi
,
Farsad Noorizadeh
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.51329/mehdiophthal1434
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.51329/mehdiophthal1434
Background: The effect of mitomycin-C (MMC) on the reduction of endothelial cell count in the cornea remains controversial. We aimed to evaluate the effect of MMC on corneal endothelial cell parameters after refractive surface ablation procedures, including photorefractive keratectomy (PRK) and laser epithelial keratomileusis (LASEK). Methods: In this interventional, comparative, follow-up study, 342 eyes of 171 patients were followed up for 6 months. Patients undergoing PRK or LASEK were included and were divided into two groups: group one (188 eyes of 94 patients) with an ablation depth of ? 65 µm and who received intraoperative 0.02% MMC for 30 s, and group two (154 eyes of 77 patients) with an ablation depth of < 65 µm and who received balanced salt solution for 30 s. Changes in endothelial cell density (ECD), central corneal thickness (CCT), coefficient of variation (CV), and hexagonality values were compared between the groups at 3 and 6 months after surgery. Results: The mean ± standard deviaiton (SD) age of the patients was 28.11 ± 6.56 years. The mean ± SD ECD did not change significantly in either group between the baseline and at 3 and 6 months postoperatively. The baseline mean ECD was significantly higher in group one than that in group two (P < 0.001) and remained so at 3 (P = 0.002) and 6 months (P = 0.022) postoperatively. The baseline hexagonality value was lower in group one (P = 0.173), with a gradual decrease during the postoperative follow-up as compared with that in group two (P = 0.016 and 0.001 at 3 and 6 months postoperatively, respectively). Group one had a significantly lower CCT at 3 and 6 months postoperatively (both P < 0.001) and a higher mean CV (3 months: P = 0.028; 6 months: P = 0.328). Conclusions: A single intraoperative application of MMC for 30 s as prophylaxis for corneal haze development during refractive surface ablation procedures had no significant effect on ECD up to 6 months postoperatively. Future studies with a contralateral-eye design (to neutralize factors specific to the individual patient), a larger sample size, and longer follow-up are necessary to confirm or disprove our observations.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.51329/mehdiophthal1434
- https://mehdijournal.com/index.php/mehdiophthalmol/article/download/970/526
- OA Status
- diamond
- Cited By
- 6
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4213450346
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4213450346Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.51329/mehdiophthal1434Digital Object Identifier
- Title
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Effect of mitomycin-C on corneal endothelial cell parameters after refractive surface ablation proceduresWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-24Full publication date if available
- Authors
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Hossein Mohammad-Rabei, Raheleh Moravej, Mina Almasi‐Nasrabadi, Parisa Rezazadeh, Navid Manafi, Farsad NoorizadehList of authors in order
- Landing page
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https://doi.org/10.51329/mehdiophthal1434Publisher landing page
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https://mehdijournal.com/index.php/mehdiophthalmol/article/download/970/526Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://mehdijournal.com/index.php/mehdiophthalmol/article/download/970/526Direct OA link when available
- Concepts
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Photorefractive keratectomy, Ablation, Keratomileusis, Medicine, Mitomycin C, Ophthalmology, Cornea, Refractive surgery, Surgery, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2024: 4, 2022: 2Per-year citation counts (last 5 years)
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29Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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