2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial Article Swipe

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Marie‐Laure Chaix , Isabelle Charreau , Claire Pintado , Constance Delaugerre , Nadia Mahjoub , Laurent Cotte , Catherine Capitant , F. Raffi , Éric Cua , Gilles Pialoux , Cécile Tremblay , Laurence Meyer , Jean‐Michel Molina , Claire Pintado , Bénédicte Loze , Constance Delaugerre , P Charbonneau , Caroline Gatey , Diane Ponscarme , Pauline Penot , Laurence Niedbalski , R. Verón , Juan F. Delgado , Ernest Dallé , S Parlier , Isabelle Madelaine , Julien Fonsart , Marie Danet , Nadia Mahjoub , N Mezreb , Khafil Moudachirou , Stéphane Morel , G Conort , F Lorho , M Meunier , Willy Rozenbaum , Jean‐Michel Molina , Julie Chas , Christine Monfort , J Foucoin , B Boissavy , S Cousseau , S Huon , Marie Danet , A Djessima , V Berrebi , Anne Adda , S. Le Nagat , L. Zarka , J Berdougo , Gilles Pialoux , Christian Chidiac , N. Mzoughi , Fiona Clement , A Decouty , C Chapolard , Matthieu Godinot , C. Adouard-groslafeige , J. Koffi , Aymeric Pansu , Ann De Becker , Sophie Pailhes , Fabrice Bonnet , François Jeanblanc , Céline Brochier‐Armanet , X Teruin , Soumaya El Rouby , L Gilly , Laurent Cotte , C Etienne , F Tolonin , S Bréaud , V Péchenot , S Bagge , T Cepitelli , P. Roger , E Rosenthal , Éric Cua , Antoine Chéret , Pauline Cornavin , Sarah Vandamme , J Lambec , N Dumon , O Leclanche , T. Huleux , Raphaël Biekre , Olivier Robineau , Hugues Melliez , H. Bazus , A. Pasquet , C Bernaud , Michel Besnier , B. Bonnet , Nolwenn Hall , M Cavellec , H Hüe , L Larmet , Marina Vera Colás , Rémy Choquet , F. Raffi ·

YOU? · · 2018 · Open Access · · DOI: https://doi.org/10.1093/ofid/ofy295

We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.

Related Topics

Medicine

Pre-Exposure Prophylaxis

Placebo

Herpes Simplex Virus

Men Who Have Sex With Men

Concepts

Medicine Emtricitabine Pre-exposure prophylaxis Incidence (geometry) Placebo Herpes simplex virus Men who have sex with men Population Tenofovir Internal medicine Virology Viral load Human immunodeficiency virus (HIV) Virus Antiretroviral therapy Environmental health Syphilis Physics Optics Alternative medicine Pathology

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Type: article
Language: en
Landing Page: https://doi.org/10.1093/ofid/ofy295
PDF: https://academic.oup.com/ofid/article-pdf/5/11/ofy295/33629703/ofy295.pdf
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Cited By: 15
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DOI: https://doi.org/10.1093/ofid/ofy295

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Title: Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

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Publication year: 2018

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Publication date: 2018-11-01

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Authors: Marie‐Laure Chaix, Isabelle Charreau, Claire Pintado, Constance Delaugerre, Nadia Mahjoub, Laurent Cotte, Catherine Capitant, F. Raffi, Éric Cua, Gilles Pialoux, Cécile Tremblay, Laurence Meyer, Jean‐Michel Molina, Claire Pintado, Bénédicte Loze, Constance Delaugerre, P Charbonneau, Caroline Gatey, Diane Ponscarme, Pauline Penot, Laurence Niedbalski, R. Verón, Juan F. Delgado, Ernest Dallé, S Parlier, Isabelle Madelaine, Julien Fonsart, Marie Danet, Nadia Mahjoub, N Mezreb, Khafil Moudachirou, Stéphane Morel, G Conort, F Lorho, M Meunier, Willy Rozenbaum, Jean‐Michel Molina, Julie Chas, Christine Monfort, J Foucoin, B Boissavy, S Cousseau, S Huon, Marie Danet, A Djessima, V Berrebi, Anne Adda, S. Le Nagat, L. Zarka, J Berdougo, Gilles Pialoux, Christian Chidiac, N. Mzoughi, Fiona Clement, A Decouty, C Chapolard, Matthieu Godinot, C. Adouard-groslafeige, J. Koffi, Aymeric Pansu, Ann De Becker, Sophie Pailhes, Fabrice Bonnet, François Jeanblanc, Céline Brochier‐Armanet, X Teruin, Soumaya El Rouby, L Gilly, Laurent Cotte, C Etienne, F Tolonin, S Bréaud, V Péchenot, S Bagge, T Cepitelli, P. Roger, E Rosenthal, Éric Cua, Antoine Chéret, Pauline Cornavin, Sarah Vandamme, J Lambec, N Dumon, O Leclanche, T. Huleux, Raphaël Biekre, Olivier Robineau, Hugues Melliez, H. Bazus, A. Pasquet, C Bernaud, Michel Besnier, B. Bonnet, Nolwenn Hall, M Cavellec, H Hüe, L Larmet, Marina Vera Colás, Rémy Choquet, F. Raffi

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Landing page: https://doi.org/10.1093/ofid/ofy295

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Concepts: Medicine, Emtricitabine, Pre-exposure prophylaxis, Incidence (geometry), Placebo, Herpes simplex virus, Men who have sex with men, Population, Tenofovir, Internal medicine, Virology, Viral load, Human immunodeficiency virus (HIV), Virus, Antiretroviral therapy, Environmental health, Syphilis, Physics, Optics, Alternative medicine, Pathology

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Cited by: 15

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Citations by year (recent): 2024: 3, 2023: 4, 2022: 2, 2021: 5, 2019: 1

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References (count): 14

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primary_location.is_published	True
primary_location.raw_source_name	Open Forum Infectious Diseases
primary_location.landing_page_url	https://doi.org/10.1093/ofid/ofy295
publication_date	2018-11-01
publication_year	2018
referenced_works	https://openalex.org/W2137186878, https://openalex.org/W2749420302, https://openalex.org/W2146634980, https://openalex.org/W2080732718, https://openalex.org/W1941748532, https://openalex.org/W1964489937, https://openalex.org/W2032435799, https://openalex.org/W2319917590, https://openalex.org/W2120702750, https://openalex.org/W2144000274, https://openalex.org/W2039524127, https://openalex.org/W2095844669, https://openalex.org/W2319135622, https://openalex.org/W2144991347
referenced_works_count	14
abstract_inverted_index.=	73, 97
abstract_inverted_index.(P	72, 96
abstract_inverted_index.We	1
abstract_inverted_index.at	41, 44
abstract_inverted_index.in	32, 65, 89, 109
abstract_inverted_index.of	5
abstract_inverted_index.on	17
abstract_inverted_index.to	105
abstract_inverted_index.100	57, 63, 81, 87
abstract_inverted_index.7.0	85
abstract_inverted_index.7.6	79
abstract_inverted_index.7.8	61
abstract_inverted_index.8.1	83
abstract_inverted_index.and	43, 60, 68, 84, 92
abstract_inverted_index.for	13, 48
abstract_inverted_index.men	24, 29
abstract_inverted_index.per	56, 62, 80, 86
abstract_inverted_index.sex	27
abstract_inverted_index.the	3, 33, 45, 66, 90
abstract_inverted_index.was	54, 78
abstract_inverted_index.who	25
abstract_inverted_index.11.7	55
abstract_inverted_index.16.2	59
abstract_inverted_index.ANRS	34
abstract_inverted_index.PrEP	101
abstract_inverted_index.arm,	70, 94
abstract_inverted_index.have	26
abstract_inverted_index.last	46
abstract_inverted_index.oral	7, 100
abstract_inverted_index.this	110
abstract_inverted_index.were	39
abstract_inverted_index.with	28, 102
abstract_inverted_index.(FTC)	12
abstract_inverted_index.(MSM)	30
abstract_inverted_index..19).	74
abstract_inverted_index..75).	98
abstract_inverted_index.HSV-1	52
abstract_inverted_index.HSV-2	76
abstract_inverted_index.Serum	37
abstract_inverted_index.among	23
abstract_inverted_index.virus	20
abstract_inverted_index.visit	47
abstract_inverted_index.(PrEP)	16
abstract_inverted_index.failed	104
abstract_inverted_index.herpes	18
abstract_inverted_index.impact	4
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abstract_inverted_index.tested	40
abstract_inverted_index.trial.	36
abstract_inverted_index.HSV-1/2	49, 107
abstract_inverted_index.IPERGAY	35
abstract_inverted_index.Overall	51, 75
abstract_inverted_index.TDF/FTC	67, 91, 103
abstract_inverted_index.placebo	69, 93
abstract_inverted_index.samples	38
abstract_inverted_index.simplex	19
abstract_inverted_index.Abstract	0
abstract_inverted_index.baseline	42
abstract_inverted_index.enrolled	31
abstract_inverted_index.fumarate	10
abstract_inverted_index.(HSV)-1/2	21
abstract_inverted_index.On-demand	99
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abstract_inverted_index.person-years;	58, 82
abstract_inverted_index.(TDF)/emtricitabine	11
cited_by_percentile_year.max	98
cited_by_percentile_year.min	90
countries_distinct_count	2
institutions_distinct_count	200
sustainable_development_goals[0].id	https://metadata.un.org/sdg/3
sustainable_development_goals[0].score	0.7099999785423279
sustainable_development_goals[0].display_name	Good health and well-being
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