Effect of PACAP on Heat Exposure Article Swipe
Keisuke Suzuki
,
Hiroki Yamaga
,
Hirokazu Ohtaki
,
Satoshi Hirako
,
Kazuyuki Miyamoto
,
Motoyasu Nakamura
,
Kaoru Yanagisawa
,
Takuya Shimada
,
Tomohiko Hosono
,
Hitoshi Hashimoto
,
Kazuho Honda
,
Kenji Dohi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24043992
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/ijms24043992
Heat stroke is a life-threatening illness caused by exposure to high ambient temperatures and relative humidity. The incidence of heat stroke is expected to increase due to climate change. Although pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in thermoregulation, the role of PACAP on heat stress remains unclear. PACAP knockout (KO) and wild-type ICR mice were subjected to heat exposure at an ambient temperature of 36 °C and relative humidity of 99% for 30–150 min. After heat exposure, the PACAP KO mice had a greater survival rate and maintained a lower body temperature than the wild-type mice. Moreover, the gene expression and immunoreaction of c-Fos in the ventromedially preoptic area of the hypothalamus, which is known to harbor temperature-sensitive neurons, were significantly lower in PACAP KO mice than those in wild-type mice. In addition, differences were observed in the brown adipose tissue, the primary site of heat production, between PACAP KO and wild-type mice. These results suggest that PACAP KO mice are resistant to heat exposure. The heat production mechanism differs between PACAP KO and wild-type mice.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms24043992
- https://www.mdpi.com/1422-0067/24/4/3992/pdf?version=1676541416
- OA Status
- gold
- Cited By
- 6
- References
- 54
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4321107085
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4321107085Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/ijms24043992Digital Object Identifier
- Title
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Effect of PACAP on Heat ExposureWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-02-16Full publication date if available
- Authors
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Keisuke Suzuki, Hiroki Yamaga, Hirokazu Ohtaki, Satoshi Hirako, Kazuyuki Miyamoto, Motoyasu Nakamura, Kaoru Yanagisawa, Takuya Shimada, Tomohiko Hosono, Hitoshi Hashimoto, Kazuho Honda, Kenji DohiList of authors in order
- Landing page
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https://doi.org/10.3390/ijms24043992Publisher landing page
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https://www.mdpi.com/1422-0067/24/4/3992/pdf?version=1676541416Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/24/4/3992/pdf?version=1676541416Direct OA link when available
- Concepts
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Internal medicine, Endocrinology, Adenylate kinase, Thermoregulation, Hypothalamus, Wild type, Preoptic area, Knockout mouse, Chemistry, Relative humidity, Cyclase, Biology, Gene, Biochemistry, Medicine, Stimulation, Receptor, Thermodynamics, Mutant, PhysicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
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2025: 3, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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54Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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