Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing Article Swipe
Hui Su
,
Haipeng Xue
,
Shang Gao
,
Binghan Yan
,
Ruochong Wang
,
Guoqing Tan
,
Zhanwang Xu
,
Lingfeng Zeng
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2022.930912
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2022.930912
Osteoporosis is increasingly becoming a serious problem affecting the quality of life of the older population. Several experimental studies have shown that Chinese medicine has a definite effect on improving osteoporosis. Based on transcriptome sequencing, we analyzed the differential gene expression and mechanism of the related signaling pathways. Fifteen rats were randomly divided into an experimental group, a model group, and a sham surgery group. The rat model for menopausal osteoporosis was established using an ovariectomy method. One week after modeling, the experimental group was administered(intragastric administration)8.1 g/kg of Rhizoma drynariae , whereas the model and sham groups received 0.9% saline solution twice daily for 12 weeks. Subsequently, the rats were sacrificed, and the left femur of each group was removed for computerized tomography testing, while right femurs were used for hematoxylin and eosin staining. High-throughput RNA sequencing and functional and pathway enrichment analyses were performed. Comparing the gene expression between the experimental and model groups, 149 differential genes were identified, of which 44 were downregulated and 105 were upregulated. The criteria for statistical significance were |log2 Fold Change| > 1 and P < 0.05. Gene ontology analysis showed that the differentially expressed genes were enriched in cell component terms such as cell part and outer cell membrane part, and the genes were associated with cell process, biological regulation, metabolic processes, DNA transcription, and catalytic activity. Enrichment analysis of Kyoto Encyclopedia of Genes and Genomes pathways showed significantly enriched pathways associated with systemic lupus erythematosus, herpes simplex infection, circadian rhythm, vascular smooth muscle contraction, the AGE-RAGE signaling pathway in diabetic complications, and the TNF, Apelin, and Ras signaling pathways. Our results revealed that the Npas2, Dbp, Rt1, Arntl, Grem2, H2bc9, LOC501233, Pla2g2c, Hpgd, Pde6c, and Dner genes, and the circadian rhythm, lipid metabolism, inflammatory signaling pathway, and immune pathways may be the key targets and pathways for traditional Chinese medicine therapy of Rhizoma Drynariae in osteoporosis.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2022.930912
- OA Status
- gold
- Cited By
- 6
- References
- 53
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4289523036
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4289523036Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2022.930912Digital Object Identifier
- Title
-
Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-08-02Full publication date if available
- Authors
-
Hui Su, Haipeng Xue, Shang Gao, Binghan Yan, Ruochong Wang, Guoqing Tan, Zhanwang Xu, Lingfeng ZengList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2022.930912Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fendo.2022.930912Direct OA link when available
- Concepts
-
KEGG, Transcriptome, Osteoporosis, Ovariectomized rat, Gene expression, H&E stain, Gene, Downregulation and upregulation, Biology, Medicine, Endocrinology, Internal medicine, Andrology, Estrogen, Pathology, Staining, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
6Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 2, 2023: 1Per-year citation counts (last 5 years)
- References (count)
-
53Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4289523036 |
|---|---|
| doi | https://doi.org/10.3389/fendo.2022.930912 |
| ids.doi | https://doi.org/10.3389/fendo.2022.930912 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/35983515 |
| ids.openalex | https://openalex.org/W4289523036 |
| fwci | 0.73841495 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D005260 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Female |
| mesh[2].qualifier_ui | Q000188 |
| mesh[2].descriptor_ui | D010024 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | drug therapy |
| mesh[2].descriptor_name | Osteoporosis |
| mesh[3].qualifier_ui | Q000235 |
| mesh[3].descriptor_ui | D010024 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | genetics |
| mesh[3].descriptor_name | Osteoporosis |
| mesh[4].qualifier_ui | Q000235 |
| mesh[4].descriptor_ui | D029621 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | genetics |
| mesh[4].descriptor_name | Polypodiaceae |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D011788 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Quality of Life |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D051381 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Rats |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D027343 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Rhizome |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D059467 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Transcriptome |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D000818 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Animals |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D005260 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Female |
| mesh[11].qualifier_ui | Q000188 |
| mesh[11].descriptor_ui | D010024 |
| mesh[11].is_major_topic | True |
| mesh[11].qualifier_name | drug therapy |
| mesh[11].descriptor_name | Osteoporosis |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D010024 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Osteoporosis |
| mesh[13].qualifier_ui | Q000235 |
| mesh[13].descriptor_ui | D029621 |
| mesh[13].is_major_topic | True |
| mesh[13].qualifier_name | genetics |
| mesh[13].descriptor_name | Polypodiaceae |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D011788 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Quality of Life |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D051381 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Rats |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D027343 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Rhizome |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D059467 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Transcriptome |
| type | article |
| title | Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing |
| biblio.issue | |
| biblio.volume | 13 |
| biblio.last_page | 930912 |
| biblio.first_page | 930912 |
| topics[0].id | https://openalex.org/T11219 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9993000030517578 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1312 |
| topics[0].subfield.display_name | Molecular Biology |
| topics[0].display_name | Bone Metabolism and Diseases |
| topics[1].id | https://openalex.org/T14245 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9976000189781189 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | Biomarkers in Disease Mechanisms |
| topics[2].id | https://openalex.org/T13430 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9815000295639038 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2705 |
| topics[2].subfield.display_name | Cardiology and Cardiovascular Medicine |
| topics[2].display_name | Lipid metabolism and disorders |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320324174 |
| funders[1].ror | |
| funders[1].display_name | Natural Science Foundation of Shandong Province |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C152724338 |
| concepts[0].level | 5 |
| concepts[0].score | 0.7703529596328735 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q909442 |
| concepts[0].display_name | KEGG |
| concepts[1].id | https://openalex.org/C162317418 |
| concepts[1].level | 4 |
| concepts[1].score | 0.722469687461853 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q252857 |
| concepts[1].display_name | Transcriptome |
| concepts[2].id | https://openalex.org/C2776541429 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6498503684997559 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q165328 |
| concepts[2].display_name | Osteoporosis |
| concepts[3].id | https://openalex.org/C8264082 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5865579843521118 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7113259 |
| concepts[3].display_name | Ovariectomized rat |
| concepts[4].id | https://openalex.org/C150194340 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5558633208274841 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q26972 |
| concepts[4].display_name | Gene expression |
| concepts[5].id | https://openalex.org/C125473707 |
| concepts[5].level | 3 |
| concepts[5].score | 0.49788737297058105 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q9914 |
| concepts[5].display_name | H&E stain |
| concepts[6].id | https://openalex.org/C104317684 |
| concepts[6].level | 2 |
| concepts[6].score | 0.46064072847366333 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[6].display_name | Gene |
| concepts[7].id | https://openalex.org/C127561419 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4361845850944519 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[7].display_name | Downregulation and upregulation |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.43224290013313293 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C71924100 |
| concepts[9].level | 0 |
| concepts[9].score | 0.42352694272994995 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[9].display_name | Medicine |
| concepts[10].id | https://openalex.org/C134018914 |
| concepts[10].level | 1 |
| concepts[10].score | 0.4179515540599823 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[10].display_name | Endocrinology |
| concepts[11].id | https://openalex.org/C126322002 |
| concepts[11].level | 1 |
| concepts[11].score | 0.38237160444259644 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[11].display_name | Internal medicine |
| concepts[12].id | https://openalex.org/C16685009 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3206046223640442 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q335057 |
| concepts[12].display_name | Andrology |
| concepts[13].id | https://openalex.org/C2777164284 |
| concepts[13].level | 2 |
| concepts[13].score | 0.26694512367248535 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q277954 |
| concepts[13].display_name | Estrogen |
| concepts[14].id | https://openalex.org/C142724271 |
| concepts[14].level | 1 |
| concepts[14].score | 0.21399489045143127 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[14].display_name | Pathology |
| concepts[15].id | https://openalex.org/C74864618 |
| concepts[15].level | 2 |
| concepts[15].score | 0.18094712495803833 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q2332446 |
| concepts[15].display_name | Staining |
| concepts[16].id | https://openalex.org/C54355233 |
| concepts[16].level | 1 |
| concepts[16].score | 0.1668170690536499 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[16].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/kegg |
| keywords[0].score | 0.7703529596328735 |
| keywords[0].display_name | KEGG |
| keywords[1].id | https://openalex.org/keywords/transcriptome |
| keywords[1].score | 0.722469687461853 |
| keywords[1].display_name | Transcriptome |
| keywords[2].id | https://openalex.org/keywords/osteoporosis |
| keywords[2].score | 0.6498503684997559 |
| keywords[2].display_name | Osteoporosis |
| keywords[3].id | https://openalex.org/keywords/ovariectomized-rat |
| keywords[3].score | 0.5865579843521118 |
| keywords[3].display_name | Ovariectomized rat |
| keywords[4].id | https://openalex.org/keywords/gene-expression |
| keywords[4].score | 0.5558633208274841 |
| keywords[4].display_name | Gene expression |
| keywords[5].id | https://openalex.org/keywords/h-e-stain |
| keywords[5].score | 0.49788737297058105 |
| keywords[5].display_name | H&E stain |
| keywords[6].id | https://openalex.org/keywords/gene |
| keywords[6].score | 0.46064072847366333 |
| keywords[6].display_name | Gene |
| keywords[7].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[7].score | 0.4361845850944519 |
| keywords[7].display_name | Downregulation and upregulation |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.43224290013313293 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/medicine |
| keywords[9].score | 0.42352694272994995 |
| keywords[9].display_name | Medicine |
| keywords[10].id | https://openalex.org/keywords/endocrinology |
| keywords[10].score | 0.4179515540599823 |
| keywords[10].display_name | Endocrinology |
| keywords[11].id | https://openalex.org/keywords/internal-medicine |
| keywords[11].score | 0.38237160444259644 |
| keywords[11].display_name | Internal medicine |
| keywords[12].id | https://openalex.org/keywords/andrology |
| keywords[12].score | 0.3206046223640442 |
| keywords[12].display_name | Andrology |
| keywords[13].id | https://openalex.org/keywords/estrogen |
| keywords[13].score | 0.26694512367248535 |
| keywords[13].display_name | Estrogen |
| keywords[14].id | https://openalex.org/keywords/pathology |
| keywords[14].score | 0.21399489045143127 |
| keywords[14].display_name | Pathology |
| keywords[15].id | https://openalex.org/keywords/staining |
| keywords[15].score | 0.18094712495803833 |
| keywords[15].display_name | Staining |
| keywords[16].id | https://openalex.org/keywords/genetics |
| keywords[16].score | 0.1668170690536499 |
| keywords[16].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.3389/fendo.2022.930912 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597401208 |
| locations[0].source.issn | 1664-2392 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-2392 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Endocrinology |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Endocrinology |
| locations[0].landing_page_url | https://doi.org/10.3389/fendo.2022.930912 |
| locations[1].id | pmid:35983515 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in endocrinology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/35983515 |
| locations[2].id | pmh:oai:doaj.org/article:9c5cf673d28b49a1bb940bb179c3f4b5 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Endocrinology, Vol 13 (2022) |
| locations[2].landing_page_url | https://doaj.org/article/9c5cf673d28b49a1bb940bb179c3f4b5 |
| locations[3].id | pmh:oai:pubmedcentral.nih.gov:9380231 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S2764455111 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | PubMed Central |
| locations[3].source.host_organization | https://openalex.org/I1299303238 |
| locations[3].source.host_organization_name | National Institutes of Health |
| locations[3].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Front Endocrinol (Lausanne) |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/9380231 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5100567767 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Hui Su |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I134738993 |
| authorships[0].affiliations[0].raw_affiliation_string | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[0].institutions[0].id | https://openalex.org/I134738993 |
| authorships[0].institutions[0].ror | https://ror.org/0523y5c19 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I134738993 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Shandong University of Traditional Chinese Medicine |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Hui Su |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[1].author.id | https://openalex.org/A5101604914 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3209-6081 |
| authorships[1].author.display_name | Haipeng Xue |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210159257 |
| authorships[1].affiliations[0].raw_affiliation_string | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[1].institutions[0].id | https://openalex.org/I4210159257 |
| authorships[1].institutions[0].ror | https://ror.org/052q26725 |
| authorships[1].institutions[0].type | healthcare |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210159257 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Affiliated Hospital of Shandong University of Traditional Chinese Medicine |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Haipeng Xue |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[2].author.id | https://openalex.org/A5102769979 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0135-6116 |
| authorships[2].author.display_name | Shang Gao |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I134738993 |
| authorships[2].affiliations[0].raw_affiliation_string | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[2].institutions[0].id | https://openalex.org/I134738993 |
| authorships[2].institutions[0].ror | https://ror.org/0523y5c19 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I134738993 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Shandong University of Traditional Chinese Medicine |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Shang Gao |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[3].author.id | https://openalex.org/A5003919138 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Binghan Yan |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I134738993 |
| authorships[3].affiliations[0].raw_affiliation_string | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[3].institutions[0].id | https://openalex.org/I134738993 |
| authorships[3].institutions[0].ror | https://ror.org/0523y5c19 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I134738993 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Shandong University of Traditional Chinese Medicine |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Binghan Yan |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[4].author.id | https://openalex.org/A5069814049 |
| authorships[4].author.orcid | https://orcid.org/0009-0004-3098-153X |
| authorships[4].author.display_name | Ruochong Wang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210148966 |
| authorships[4].affiliations[0].raw_affiliation_string | College of traditional Chinese medicine, Beijing University of Traditional Chinese Medicine, Beijing, China |
| authorships[4].institutions[0].id | https://openalex.org/I4210148966 |
| authorships[4].institutions[0].ror | https://ror.org/057vq6e26 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210148966 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Beijing Hospital of Traditional Chinese Medicine |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ruochong Wang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | College of traditional Chinese medicine, Beijing University of Traditional Chinese Medicine, Beijing, China |
| authorships[5].author.id | https://openalex.org/A5110372710 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Guoqing Tan |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210159257 |
| authorships[5].affiliations[0].raw_affiliation_string | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[5].institutions[0].id | https://openalex.org/I4210159257 |
| authorships[5].institutions[0].ror | https://ror.org/052q26725 |
| authorships[5].institutions[0].type | healthcare |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210159257 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Affiliated Hospital of Shandong University of Traditional Chinese Medicine |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Guoqing Tan |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[6].author.id | https://openalex.org/A5102145594 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Zhanwang Xu |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I134738993 |
| authorships[6].affiliations[0].raw_affiliation_string | First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I4210159257 |
| authorships[6].affiliations[1].raw_affiliation_string | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[6].institutions[0].id | https://openalex.org/I4210159257 |
| authorships[6].institutions[0].ror | https://ror.org/052q26725 |
| authorships[6].institutions[0].type | healthcare |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210159257 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Affiliated Hospital of Shandong University of Traditional Chinese Medicine |
| authorships[6].institutions[1].id | https://openalex.org/I134738993 |
| authorships[6].institutions[1].ror | https://ror.org/0523y5c19 |
| authorships[6].institutions[1].type | education |
| authorships[6].institutions[1].lineage | https://openalex.org/I134738993 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | Shandong University of Traditional Chinese Medicine |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Zhanwang Xu |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China, First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, China |
| authorships[7].author.id | https://openalex.org/A5071484833 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Lingfeng Zeng |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210105832 |
| authorships[7].affiliations[0].raw_affiliation_string | The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China |
| authorships[7].institutions[0].id | https://openalex.org/I4210105832 |
| authorships[7].institutions[0].ror | https://ror.org/01mxpdw03 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210105832 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | First Affiliated Hospital of Guangzhou University of Chinese Medicine |
| authorships[7].author_position | last |
| authorships[7].raw_author_name | Lingfeng Zeng |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | The 2nd Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3389/fendo.2022.930912 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Effect of Rhizoma Drynariae on differential gene expression in ovariectomized rats with osteoporosis based on transcriptome sequencing |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11219 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9993000030517578 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1312 |
| primary_topic.subfield.display_name | Molecular Biology |
| primary_topic.display_name | Bone Metabolism and Diseases |
| related_works | https://openalex.org/W2386420363, https://openalex.org/W2398068415, https://openalex.org/W2407350564, https://openalex.org/W2393570286, https://openalex.org/W2415454268, https://openalex.org/W2093572014, https://openalex.org/W2070612534, https://openalex.org/W2385939269, https://openalex.org/W2386145651, https://openalex.org/W2297026197 |
| cited_by_count | 6 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 1 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fendo.2022.930912 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597401208 |
| best_oa_location.source.issn | 1664-2392 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-2392 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Endocrinology |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Endocrinology |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fendo.2022.930912 |
| primary_location.id | doi:10.3389/fendo.2022.930912 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597401208 |
| primary_location.source.issn | 1664-2392 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-2392 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Endocrinology |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Endocrinology |
| primary_location.landing_page_url | https://doi.org/10.3389/fendo.2022.930912 |
| publication_date | 2022-08-02 |
| publication_year | 2022 |
| referenced_works | https://openalex.org/W2917396216, https://openalex.org/W4253165656, https://openalex.org/W9111973, https://openalex.org/W3138944102, https://openalex.org/W4240746421, https://openalex.org/W4205892246, https://openalex.org/W3159572077, https://openalex.org/W2369391196, https://openalex.org/W3184435308, https://openalex.org/W3041083709, https://openalex.org/W4200168965, https://openalex.org/W2940728339, https://openalex.org/W2768536442, https://openalex.org/W2965631439, https://openalex.org/W1212791449, https://openalex.org/W2032445654, https://openalex.org/W2053372607, https://openalex.org/W2531102774, https://openalex.org/W4214835936, https://openalex.org/W3114290663, https://openalex.org/W2806898809, https://openalex.org/W1553211937, https://openalex.org/W2989597194, https://openalex.org/W2343218602, https://openalex.org/W2401223252, https://openalex.org/W3045012095, https://openalex.org/W2049557764, https://openalex.org/W2116527577, https://openalex.org/W2948388080, https://openalex.org/W2288809269, https://openalex.org/W3007040252, https://openalex.org/W3159467375, https://openalex.org/W2164389297, https://openalex.org/W2161162458, https://openalex.org/W2983808900, https://openalex.org/W2899256506, https://openalex.org/W2331923226, https://openalex.org/W4226092282, https://openalex.org/W2996964976, https://openalex.org/W2074805179, https://openalex.org/W2072826845, https://openalex.org/W2414441303, https://openalex.org/W3016507601, https://openalex.org/W2008488475, https://openalex.org/W2941723879, https://openalex.org/W2081678861, https://openalex.org/W2006705474, https://openalex.org/W2935715926, https://openalex.org/W3049555716, https://openalex.org/W2126135274, https://openalex.org/W2956714488, https://openalex.org/W2417995089, https://openalex.org/W2107490395 |
| referenced_works_count | 53 |
| abstract_inverted_index., | 91 |
| abstract_inverted_index.1 | 180 |
| abstract_inverted_index.P | 182 |
| abstract_inverted_index.a | 4, 25, 57, 61 |
| abstract_inverted_index.12 | 105 |
| abstract_inverted_index.44 | 163 |
| abstract_inverted_index.an | 54, 74 |
| abstract_inverted_index.as | 201 |
| abstract_inverted_index.be | 300 |
| abstract_inverted_index.in | 196, 258, 314 |
| abstract_inverted_index.is | 1 |
| abstract_inverted_index.of | 10, 12, 43, 88, 116, 161, 228, 231, 311 |
| abstract_inverted_index.on | 28, 32 |
| abstract_inverted_index.we | 35 |
| abstract_inverted_index.105 | 167 |
| abstract_inverted_index.149 | 156 |
| abstract_inverted_index.DNA | 221 |
| abstract_inverted_index.One | 77 |
| abstract_inverted_index.Our | 269 |
| abstract_inverted_index.RNA | 136 |
| abstract_inverted_index.Ras | 266 |
| abstract_inverted_index.The | 65, 170 |
| abstract_inverted_index.and | 41, 60, 95, 112, 132, 138, 140, 153, 166, 181, 204, 209, 223, 233, 261, 265, 284, 287, 296, 304 |
| abstract_inverted_index.for | 68, 104, 121, 130, 172, 306 |
| abstract_inverted_index.has | 24 |
| abstract_inverted_index.key | 302 |
| abstract_inverted_index.may | 299 |
| abstract_inverted_index.rat | 66 |
| abstract_inverted_index.the | 8, 13, 37, 44, 81, 93, 108, 113, 147, 151, 190, 210, 254, 262, 273, 288, 301 |
| abstract_inverted_index.was | 71, 84, 119 |
| abstract_inverted_index.0.9% | 99 |
| abstract_inverted_index.Dbp, | 275 |
| abstract_inverted_index.Dner | 285 |
| abstract_inverted_index.Fold | 177 |
| abstract_inverted_index.Gene | 185 |
| abstract_inverted_index.Rt1, | 276 |
| abstract_inverted_index.TNF, | 263 |
| abstract_inverted_index.cell | 197, 202, 206, 215 |
| abstract_inverted_index.each | 117 |
| abstract_inverted_index.g/kg | 87 |
| abstract_inverted_index.gene | 39, 148 |
| abstract_inverted_index.have | 19 |
| abstract_inverted_index.into | 53 |
| abstract_inverted_index.left | 114 |
| abstract_inverted_index.life | 11 |
| abstract_inverted_index.part | 203 |
| abstract_inverted_index.rats | 49, 109 |
| abstract_inverted_index.sham | 62, 96 |
| abstract_inverted_index.such | 200 |
| abstract_inverted_index.that | 21, 189, 272 |
| abstract_inverted_index.used | 129 |
| abstract_inverted_index.week | 78 |
| abstract_inverted_index.were | 50, 110, 128, 144, 159, 164, 168, 175, 194, 212 |
| abstract_inverted_index.with | 214, 241 |
| abstract_inverted_index.0.05. | 184 |
| abstract_inverted_index.Based | 31 |
| abstract_inverted_index.Genes | 232 |
| abstract_inverted_index.Hpgd, | 282 |
| abstract_inverted_index.Kyoto | 229 |
| abstract_inverted_index.after | 79 |
| abstract_inverted_index.daily | 103 |
| abstract_inverted_index.eosin | 133 |
| abstract_inverted_index.femur | 115 |
| abstract_inverted_index.genes | 158, 193, 211 |
| abstract_inverted_index.group | 83, 118 |
| abstract_inverted_index.lipid | 291 |
| abstract_inverted_index.lupus | 243 |
| abstract_inverted_index.model | 58, 67, 94, 154 |
| abstract_inverted_index.older | 14 |
| abstract_inverted_index.outer | 205 |
| abstract_inverted_index.part, | 208 |
| abstract_inverted_index.right | 126 |
| abstract_inverted_index.shown | 20 |
| abstract_inverted_index.terms | 199 |
| abstract_inverted_index.twice | 102 |
| abstract_inverted_index.using | 73 |
| abstract_inverted_index.which | 162 |
| abstract_inverted_index.while | 125 |
| abstract_inverted_index.|log2 | 176 |
| abstract_inverted_index.Arntl, | 277 |
| abstract_inverted_index.Grem2, | 278 |
| abstract_inverted_index.H2bc9, | 279 |
| abstract_inverted_index.Npas2, | 274 |
| abstract_inverted_index.Pde6c, | 283 |
| abstract_inverted_index.effect | 27 |
| abstract_inverted_index.femurs | 127 |
| abstract_inverted_index.genes, | 286 |
| abstract_inverted_index.group, | 56, 59 |
| abstract_inverted_index.group. | 64 |
| abstract_inverted_index.groups | 97 |
| abstract_inverted_index.herpes | 245 |
| abstract_inverted_index.immune | 297 |
| abstract_inverted_index.muscle | 252 |
| abstract_inverted_index.saline | 100 |
| abstract_inverted_index.showed | 188, 236 |
| abstract_inverted_index.smooth | 251 |
| abstract_inverted_index.weeks. | 106 |
| abstract_inverted_index.Apelin, | 264 |
| abstract_inverted_index.Change| | 178 |
| abstract_inverted_index.Chinese | 22, 308 |
| abstract_inverted_index.Fifteen | 48 |
| abstract_inverted_index.Genomes | 234 |
| abstract_inverted_index.Rhizoma | 89, 312 |
| abstract_inverted_index.Several | 16 |
| abstract_inverted_index.between | 150 |
| abstract_inverted_index.divided | 52 |
| abstract_inverted_index.groups, | 155 |
| abstract_inverted_index.method. | 76 |
| abstract_inverted_index.pathway | 141, 257 |
| abstract_inverted_index.problem | 6 |
| abstract_inverted_index.quality | 9 |
| abstract_inverted_index.related | 45 |
| abstract_inverted_index.removed | 120 |
| abstract_inverted_index.results | 270 |
| abstract_inverted_index.rhythm, | 249, 290 |
| abstract_inverted_index.serious | 5 |
| abstract_inverted_index.simplex | 246 |
| abstract_inverted_index.studies | 18 |
| abstract_inverted_index.surgery | 63 |
| abstract_inverted_index.targets | 303 |
| abstract_inverted_index.therapy | 310 |
| abstract_inverted_index.whereas | 92 |
| abstract_inverted_index.&gt; | 179 |
| abstract_inverted_index.&lt; | 183 |
| abstract_inverted_index.AGE-RAGE | 255 |
| abstract_inverted_index.Pla2g2c, | 281 |
| abstract_inverted_index.analyses | 143 |
| abstract_inverted_index.analysis | 187, 227 |
| abstract_inverted_index.analyzed | 36 |
| abstract_inverted_index.becoming | 3 |
| abstract_inverted_index.criteria | 171 |
| abstract_inverted_index.definite | 26 |
| abstract_inverted_index.diabetic | 259 |
| abstract_inverted_index.enriched | 195, 238 |
| abstract_inverted_index.medicine | 23, 309 |
| abstract_inverted_index.membrane | 207 |
| abstract_inverted_index.ontology | 186 |
| abstract_inverted_index.pathway, | 295 |
| abstract_inverted_index.pathways | 235, 239, 298, 305 |
| abstract_inverted_index.process, | 216 |
| abstract_inverted_index.randomly | 51 |
| abstract_inverted_index.received | 98 |
| abstract_inverted_index.revealed | 271 |
| abstract_inverted_index.solution | 101 |
| abstract_inverted_index.systemic | 242 |
| abstract_inverted_index.testing, | 124 |
| abstract_inverted_index.vascular | 250 |
| abstract_inverted_index.Comparing | 146 |
| abstract_inverted_index.Drynariae | 313 |
| abstract_inverted_index.activity. | 225 |
| abstract_inverted_index.affecting | 7 |
| abstract_inverted_index.catalytic | 224 |
| abstract_inverted_index.circadian | 248, 289 |
| abstract_inverted_index.component | 198 |
| abstract_inverted_index.drynariae | 90 |
| abstract_inverted_index.expressed | 192 |
| abstract_inverted_index.improving | 29 |
| abstract_inverted_index.mechanism | 42 |
| abstract_inverted_index.metabolic | 219 |
| abstract_inverted_index.modeling, | 80 |
| abstract_inverted_index.pathways. | 47, 268 |
| abstract_inverted_index.signaling | 46, 256, 267, 294 |
| abstract_inverted_index.staining. | 134 |
| abstract_inverted_index.Enrichment | 226 |
| abstract_inverted_index.LOC501233, | 280 |
| abstract_inverted_index.associated | 213, 240 |
| abstract_inverted_index.biological | 217 |
| abstract_inverted_index.enrichment | 142 |
| abstract_inverted_index.expression | 40, 149 |
| abstract_inverted_index.functional | 139 |
| abstract_inverted_index.infection, | 247 |
| abstract_inverted_index.menopausal | 69 |
| abstract_inverted_index.performed. | 145 |
| abstract_inverted_index.processes, | 220 |
| abstract_inverted_index.sequencing | 137 |
| abstract_inverted_index.tomography | 123 |
| abstract_inverted_index.established | 72 |
| abstract_inverted_index.hematoxylin | 131 |
| abstract_inverted_index.identified, | 160 |
| abstract_inverted_index.metabolism, | 292 |
| abstract_inverted_index.ovariectomy | 75 |
| abstract_inverted_index.population. | 15 |
| abstract_inverted_index.regulation, | 218 |
| abstract_inverted_index.sacrificed, | 111 |
| abstract_inverted_index.sequencing, | 34 |
| abstract_inverted_index.statistical | 173 |
| abstract_inverted_index.traditional | 307 |
| abstract_inverted_index.Encyclopedia | 230 |
| abstract_inverted_index.Osteoporosis | 0 |
| abstract_inverted_index.computerized | 122 |
| abstract_inverted_index.contraction, | 253 |
| abstract_inverted_index.differential | 38, 157 |
| abstract_inverted_index.experimental | 17, 55, 82, 152 |
| abstract_inverted_index.increasingly | 2 |
| abstract_inverted_index.inflammatory | 293 |
| abstract_inverted_index.osteoporosis | 70 |
| abstract_inverted_index.significance | 174 |
| abstract_inverted_index.upregulated. | 169 |
| abstract_inverted_index.Subsequently, | 107 |
| abstract_inverted_index.downregulated | 165 |
| abstract_inverted_index.osteoporosis. | 30, 315 |
| abstract_inverted_index.significantly | 237 |
| abstract_inverted_index.transcriptome | 33 |
| abstract_inverted_index.complications, | 260 |
| abstract_inverted_index.differentially | 191 |
| abstract_inverted_index.erythematosus, | 244 |
| abstract_inverted_index.transcription, | 222 |
| abstract_inverted_index.High-throughput | 135 |
| abstract_inverted_index.administration)8.1 | 86 |
| abstract_inverted_index.administered(intragastric | 85 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5102145594, https://openalex.org/A5071484833, https://openalex.org/A5110372710 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I134738993, https://openalex.org/I4210105832, https://openalex.org/I4210159257 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.699999988079071 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.64181215 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |