Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL Particles Article Swipe
Wen Guo
,
Karol M. Pencina
,
Jeremy D. Furtado
,
Frank M. Sacks
,
Tomáš Vaisar
,
Ming Cheng
,
Allan D. Sniderman
,
Stephanie T. Page
,
Shalender Bhasin
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvac099
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1210/jendso/bvac099
Context Selective androgen receptor modulators (SARMs), because of their preferential muscle vs prostate selectivity, are being developed for muscle-wasting conditions. Oral SARMs suppress high-density lipoprotein cholesterol (HDL-C) but their effects on functional capacity and atherogenic potential of HDL particles are unknown. Objective To determine the effects of an oral SARM (OPK-88004) on cholesterol efflux capacity, HDL particle number and size, apolipoprotein particle number and size and HDL subspecies Methods We measured cholesterol efflux capacity (CEC); HDL particle number and size; APOB; APOA1; and protein-defined HDL subspecies associated with coronary heart disease (CHD) risk in men, who had undergone prostatectomy for low-grade prostate cancer during 12-week treatment with placebo or 1, 5, or 15 mg of an oral SARM (OPK-88004). Results SARM significantly suppressed HDL-C (P < .001) but HDL particle size did not change significantly. SARM had minimal effect on CEC of HDL particles (change + 0.016, –0.036, +0.070, and –0.048%/µmol-HDL/L–1 at 0, 1, 5, and 15 mg SARM, P = .045). SARM treatment suppressed APOAI (P < .001) but not APOB (P = .077), and reduced APOA1 in HDL subspecies associated with increased (subspecies containing α2-macroglobulin, complement C3, or plasminogen) as well as decreased (subspecies containing APOC1 or APOE) CHD risk; relative proportions of APOA1 in these HDL subspecies did not change. SARM increased hepatic triacylglycerol lipase (HTGL) (P < .001). Conclusion SARM treatment suppressed HDL-C but had minimal effect on its size or cholesterol efflux function. SARM reduced APOA1 in HDL subspecies associated with increased as well as decreased CHD risk. SARM-induced increase in HTGL could contribute to HDL-C suppression. These data do not support the simplistic notion that SARM-associated suppression of HDL-C is necessarily proatherogenic; randomized trials are needed to determine SARM’s effects on cardiovascular events.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1210/jendso/bvac099
- https://academic.oup.com/jes/article-pdf/6/8/bvac099/44805414/bvac099.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283656181
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4283656181Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1210/jendso/bvac099Digital Object Identifier
- Title
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Effect of Selective Androgen Receptor Modulator on Cholesterol Efflux Capacity, Size, and Subspecies of HDL ParticlesWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-06-28Full publication date if available
- Authors
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Wen Guo, Karol M. Pencina, Jeremy D. Furtado, Frank M. Sacks, Tomáš Vaisar, Ming Cheng, Allan D. Sniderman, Stephanie T. Page, Shalender BhasinList of authors in order
- Landing page
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https://doi.org/10.1210/jendso/bvac099Publisher landing page
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https://academic.oup.com/jes/article-pdf/6/8/bvac099/44805414/bvac099.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://academic.oup.com/jes/article-pdf/6/8/bvac099/44805414/bvac099.pdfDirect OA link when available
- Concepts
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Apolipoprotein B, Internal medicine, Endocrinology, Cholesterol, Efflux, Subspecies, Chemistry, Lipoprotein, Biology, Medicine, Biochemistry, EcologyTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
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2025: 2, 2024: 1, 2023: 1, 2022: 1Per-year citation counts (last 5 years)
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59Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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