Effect of the order of concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle Article Swipe

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Takanaga Shirai , Hideto Hanakita , Kazuki Uemichi , Tohru Takemasa ·

YOU? · · 2021 · Open Access · · DOI: https://doi.org/10.14814/phy2.14770

Athletes train to improve strength and endurance to demonstrate maximum performance during competitions. Training methods vary but most focus on strength, endurance, or both. Concurrent training is a combination of two different modes of training. In this study, we combined resistance exercise (RE) and high-intensity interval exercise (HIIE) to investigate the influence of the order of the concurrent training on signal molecules on hypertrophy and glycolysis in the skeletal muscle. The phosphorylation levels of mechanistic target of rapamycin (mTOR) signals, p70 S6 kinase (p70S6 K), ribosomal protein S6 (S6), and glycogen synthase kinase beta (GSK-3β) were significantly increased in the HIIE first group compared with the control group. The combined training course did not affect the glycogen content and expression levels of proteins concerning glycolytic and metabolic capacity, suggesting that a combination of HIIE and RE on the same day, with HIIE prior to RE, improves hypertrophy response and glycolysis enhancement.

Related Topics

High-Intensity Interval Training

Concepts

Glycolysis Glycogen High-intensity interval training Ribosomal protein s6 Endurance training Skeletal muscle Muscle hypertrophy Internal medicine Endocrinology Kinase PI3K/AKT/mTOR pathway Interval training Phosphorylation Strength training Glycogen synthase Biology Metabolism P70-S6 Kinase 1 Medicine Biochemistry Signal transduction Physiology

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Type: article
Language: en
Landing Page: https://doi.org/10.14814/phy2.14770
PDF: https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.14770
OA Status: gold
Cited By: 12
References: 40
Related Works: 10
OpenAlex ID: https://openalex.org/W3134878355

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DOI: https://doi.org/10.14814/phy2.14770

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Title: Effect of the order of concurrent training combined with resistance and high‐intensity interval exercise on mTOR signaling and glycolytic metabolism in mouse skeletal muscle

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Type: article

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Language: en

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Publication year: 2021

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Publication date: 2021-03-01

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Authors: Takanaga Shirai, Hideto Hanakita, Kazuki Uemichi, Tohru Takemasa

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Landing page: https://doi.org/10.14814/phy2.14770

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PDF URL: https://onlinelibrary.wiley.com/doi/pdfdirect/10.14814/phy2.14770

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Concepts: Glycolysis, Glycogen, High-intensity interval training, Ribosomal protein s6, Endurance training, Skeletal muscle, Muscle hypertrophy, Internal medicine, Endocrinology, Kinase, PI3K/AKT/mTOR pathway, Interval training, Phosphorylation, Strength training, Glycogen synthase, Biology, Metabolism, P70-S6 Kinase 1, Medicine, Biochemistry, Signal transduction, Physiology

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Cited by: 12

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Citations by year (recent): 2025: 5, 2023: 3, 2022: 1, 2021: 3

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Related works (count): 10

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