EPJ Web of Conferences • Vol 140
Effect of the particle shape on the particle dynamics in a spheronization process
January 2017 • Dominik Weis, Maria Niesing, Markus Thommes, Sergiy Antonyuk
Spherical granules with a narrow size distribution are widely used in many pharmaceutical applications. Extrusion-spheronization is a well-established process to produce such pharmaceutical pellets. The cylindrical extrudates from the extrusion step are rounded in the spheronizer. The formation mechanisms inside of a spheronizer depend strongly on the particle dynamics. To describe the complex particle flow and interactions, the Discrete Element Method can be used. In our previous works the spherical particles dur…