Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus Article Swipe
Taeang Arai
,
Masanori Atsukawa
,
Chikako Nagao
,
Zento Yamada
,
Takahiro Rokugo
,
Kenta Suzuki
,
Michika Kitamura
,
Tetsuyuki Higashi
,
Kaori Koyano
,
Yuta Hasegawa
,
Tadamichi Kawano
,
Hiroki Ono
,
Yūji Yoshida
,
Tomomi Okubo
,
Korenobu Hayama
,
Ai Nakagawa‐Iwashita
,
Norio Itokawa
,
Chisa Kondo
,
Mototsugu Nagao
,
Masato Iwabu
,
Katsuhiko Iwakiri
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.14241
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.14241
Aim This study aimed to clarify the impact of tirzepatide as a treatment for Type 2 diabetes mellitus (T2DM) in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Methods This single‐arm, prospective, observational pilot study included 16 patients with MASLD and T2DM who were treated with tirzepatide. Of these, 13 patients completed 48 weeks of treatment. Tirzepatide was initiated at a dose of 2.5 mg once weekly for 4 weeks, and dose adjustments were left to the discretion of the attending physician based on efficacy and adverse events. Results Significant improvements in body weight, liver enzymes, and hemoglobin A1c were found at Week 12 and were sustained throughout the 48‐week treatment period compared with baseline values (all p < 0.05). Controlled attenuation parameter significantly decreased from baseline to 48 weeks ( p < 0.05). Changes in body weight were correlated with changes in alanine aminotransferase levels ( r = 0.57, p < 0.05) but not with changes in controlled attenuation parameter ( r = 0.45, p = 0.12). The results of noninvasive tests for fibrosis, including Type IV collagen 7s, Wisteria floribunda agglutinin‐positive Mac‐2‐binding protein, the fibrosis‐4 index, and the liver stiffness measurement, significantly decreased from baseline to 48 weeks (all p < 0.05). Most adverse events were transient Grades 1–2 gastrointestinal symptoms, including nausea (5 patients, 31.3%), diarrhea (3 patients, 18.8%), and constipation (2 patients, 12.5%). Conclusions Tirzepatide treatment for T2DM in patients with MASLD significantly improved liver steatosis and injury, surrogate markers of liver fibrosis, and diabetes status, and reduced body weight.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/hepr.14241
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241
- OA Status
- hybrid
- Cited By
- 1
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412044923
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412044923Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1111/hepr.14241Digital Object Identifier
- Title
-
Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes MellitusWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-05Full publication date if available
- Authors
-
Taeang Arai, Masanori Atsukawa, Chikako Nagao, Zento Yamada, Takahiro Rokugo, Kenta Suzuki, Michika Kitamura, Tetsuyuki Higashi, Kaori Koyano, Yuta Hasegawa, Tadamichi Kawano, Hiroki Ono, Yūji Yoshida, Tomomi Okubo, Korenobu Hayama, Ai Nakagawa‐Iwashita, Norio Itokawa, Chisa Kondo, Mototsugu Nagao, Masato Iwabu, Katsuhiko IwakiriList of authors in order
- Landing page
-
https://doi.org/10.1111/hepr.14241Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241Direct OA link when available
- Concepts
-
Medicine, Internal medicine, Gastroenterology, Adverse effect, Liver disease, Type 2 Diabetes Mellitus, Constipation, Steatosis, Fatty liver, Nausea, Diabetes mellitus, Diarrhea, Endocrinology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1Per-year citation counts (last 5 years)
- References (count)
-
22Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4412044923 |
|---|---|
| doi | https://doi.org/10.1111/hepr.14241 |
| ids.doi | https://doi.org/10.1111/hepr.14241 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40616360 |
| ids.openalex | https://openalex.org/W4412044923 |
| fwci | 4.6013505 |
| type | article |
| title | Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus |
| biblio.issue | 10 |
| biblio.volume | 55 |
| biblio.last_page | 1352 |
| biblio.first_page | 1346 |
| topics[0].id | https://openalex.org/T10351 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Liver Disease Diagnosis and Treatment |
| topics[1].id | https://openalex.org/T10337 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9940999746322632 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2721 |
| topics[1].subfield.display_name | Hepatology |
| topics[1].display_name | Liver Disease and Transplantation |
| topics[2].id | https://openalex.org/T10760 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9940999746322632 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2746 |
| topics[2].subfield.display_name | Surgery |
| topics[2].display_name | Pancreatitis Pathology and Treatment |
| is_xpac | False |
| apc_list.value | 3400 |
| apc_list.currency | USD |
| apc_list.value_usd | 3400 |
| apc_paid.value | 3400 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 3400 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8631109595298767 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C126322002 |
| concepts[1].level | 1 |
| concepts[1].score | 0.7879977226257324 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[1].display_name | Internal medicine |
| concepts[2].id | https://openalex.org/C90924648 |
| concepts[2].level | 1 |
| concepts[2].score | 0.7334033250808716 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[2].display_name | Gastroenterology |
| concepts[3].id | https://openalex.org/C197934379 |
| concepts[3].level | 2 |
| concepts[3].score | 0.5817442536354065 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2047938 |
| concepts[3].display_name | Adverse effect |
| concepts[4].id | https://openalex.org/C2777075537 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5334729552268982 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q929737 |
| concepts[4].display_name | Liver disease |
| concepts[5].id | https://openalex.org/C2910068830 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5150599479675293 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q3025883 |
| concepts[5].display_name | Type 2 Diabetes Mellitus |
| concepts[6].id | https://openalex.org/C2781112942 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5042787790298462 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q178436 |
| concepts[6].display_name | Constipation |
| concepts[7].id | https://openalex.org/C2776175330 |
| concepts[7].level | 2 |
| concepts[7].score | 0.48834964632987976 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1365091 |
| concepts[7].display_name | Steatosis |
| concepts[8].id | https://openalex.org/C2778772119 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4824831783771515 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q6058862 |
| concepts[8].display_name | Fatty liver |
| concepts[9].id | https://openalex.org/C2780580376 |
| concepts[9].level | 2 |
| concepts[9].score | 0.4496857523918152 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q186889 |
| concepts[9].display_name | Nausea |
| concepts[10].id | https://openalex.org/C555293320 |
| concepts[10].level | 2 |
| concepts[10].score | 0.43744727969169617 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[10].display_name | Diabetes mellitus |
| concepts[11].id | https://openalex.org/C2779802037 |
| concepts[11].level | 2 |
| concepts[11].score | 0.42519915103912354 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q40878 |
| concepts[11].display_name | Diarrhea |
| concepts[12].id | https://openalex.org/C134018914 |
| concepts[12].level | 1 |
| concepts[12].score | 0.23364761471748352 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[12].display_name | Endocrinology |
| concepts[13].id | https://openalex.org/C2779134260 |
| concepts[13].level | 2 |
| concepts[13].score | 0.21670261025428772 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[13].display_name | Disease |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8631109595298767 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/internal-medicine |
| keywords[1].score | 0.7879977226257324 |
| keywords[1].display_name | Internal medicine |
| keywords[2].id | https://openalex.org/keywords/gastroenterology |
| keywords[2].score | 0.7334033250808716 |
| keywords[2].display_name | Gastroenterology |
| keywords[3].id | https://openalex.org/keywords/adverse-effect |
| keywords[3].score | 0.5817442536354065 |
| keywords[3].display_name | Adverse effect |
| keywords[4].id | https://openalex.org/keywords/liver-disease |
| keywords[4].score | 0.5334729552268982 |
| keywords[4].display_name | Liver disease |
| keywords[5].id | https://openalex.org/keywords/type-2-diabetes-mellitus |
| keywords[5].score | 0.5150599479675293 |
| keywords[5].display_name | Type 2 Diabetes Mellitus |
| keywords[6].id | https://openalex.org/keywords/constipation |
| keywords[6].score | 0.5042787790298462 |
| keywords[6].display_name | Constipation |
| keywords[7].id | https://openalex.org/keywords/steatosis |
| keywords[7].score | 0.48834964632987976 |
| keywords[7].display_name | Steatosis |
| keywords[8].id | https://openalex.org/keywords/fatty-liver |
| keywords[8].score | 0.4824831783771515 |
| keywords[8].display_name | Fatty liver |
| keywords[9].id | https://openalex.org/keywords/nausea |
| keywords[9].score | 0.4496857523918152 |
| keywords[9].display_name | Nausea |
| keywords[10].id | https://openalex.org/keywords/diabetes-mellitus |
| keywords[10].score | 0.43744727969169617 |
| keywords[10].display_name | Diabetes mellitus |
| keywords[11].id | https://openalex.org/keywords/diarrhea |
| keywords[11].score | 0.42519915103912354 |
| keywords[11].display_name | Diarrhea |
| keywords[12].id | https://openalex.org/keywords/endocrinology |
| keywords[12].score | 0.23364761471748352 |
| keywords[12].display_name | Endocrinology |
| keywords[13].id | https://openalex.org/keywords/disease |
| keywords[13].score | 0.21670261025428772 |
| keywords[13].display_name | Disease |
| language | en |
| locations[0].id | doi:10.1111/hepr.14241 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S110399111 |
| locations[0].source.issn | 1386-6346, 1872-034X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 1386-6346 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Hepatology Research |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | cc-by-nc |
| locations[0].pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Hepatology Research |
| locations[0].landing_page_url | https://doi.org/10.1111/hepr.14241 |
| locations[1].id | pmid:40616360 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Hepatology research : the official journal of the Japan Society of Hepatology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40616360 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5110757059 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Taeang Arai |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[0].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[0].institutions[0].id | https://openalex.org/I80188885 |
| authorships[0].institutions[0].ror | https://ror.org/00krab219 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Nippon Medical School |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Taeang Arai |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[1].author.id | https://openalex.org/A5080709934 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-3374-7111 |
| authorships[1].author.display_name | Masanori Atsukawa |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[1].institutions[0].id | https://openalex.org/I80188885 |
| authorships[1].institutions[0].ror | https://ror.org/00krab219 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Nippon Medical School |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Masanori Atsukawa |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[2].author.id | https://openalex.org/A5099098787 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Chikako Nagao |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[2].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[2].institutions[0].id | https://openalex.org/I80188885 |
| authorships[2].institutions[0].ror | https://ror.org/00krab219 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Nippon Medical School |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Chikako Nagao |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[3].author.id | https://openalex.org/A5061927892 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-6958-6706 |
| authorships[3].author.display_name | Zento Yamada |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[3].institutions[0].id | https://openalex.org/I80188885 |
| authorships[3].institutions[0].ror | https://ror.org/00krab219 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Nippon Medical School |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Zento Yamada |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[4].author.id | https://openalex.org/A5092415523 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Takahiro Rokugo |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[4].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[4].institutions[0].id | https://openalex.org/I80188885 |
| authorships[4].institutions[0].ror | https://ror.org/00krab219 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Nippon Medical School |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Takahiro Rokugo |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[5].author.id | https://openalex.org/A5053750652 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-2309-6028 |
| authorships[5].author.display_name | Kenta Suzuki |
| authorships[5].countries | JP |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[5].institutions[0].id | https://openalex.org/I80188885 |
| authorships[5].institutions[0].ror | https://ror.org/00krab219 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[5].institutions[0].country_code | JP |
| authorships[5].institutions[0].display_name | Nippon Medical School |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Kenta Suzuki |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[6].author.id | https://openalex.org/A5064938881 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Michika Kitamura |
| authorships[6].countries | JP |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[6].institutions[0].id | https://openalex.org/I80188885 |
| authorships[6].institutions[0].ror | https://ror.org/00krab219 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[6].institutions[0].country_code | JP |
| authorships[6].institutions[0].display_name | Nippon Medical School |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Michika Kitamura |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[7].author.id | https://openalex.org/A5113157991 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Tetsuyuki Higashi |
| authorships[7].countries | JP |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[7].institutions[0].id | https://openalex.org/I80188885 |
| authorships[7].institutions[0].ror | https://ror.org/00krab219 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[7].institutions[0].country_code | JP |
| authorships[7].institutions[0].display_name | Nippon Medical School |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Tetsuyuki Higashi |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[8].author.id | https://openalex.org/A5022694018 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-6764-5485 |
| authorships[8].author.display_name | Kaori Koyano |
| authorships[8].countries | JP |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[8].institutions[0].id | https://openalex.org/I80188885 |
| authorships[8].institutions[0].ror | https://ror.org/00krab219 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[8].institutions[0].country_code | JP |
| authorships[8].institutions[0].display_name | Nippon Medical School |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Kaori Koyano |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[9].author.id | https://openalex.org/A5038857946 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-7647-9623 |
| authorships[9].author.display_name | Yuta Hasegawa |
| authorships[9].countries | JP |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[9].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[9].institutions[0].id | https://openalex.org/I80188885 |
| authorships[9].institutions[0].ror | https://ror.org/00krab219 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[9].institutions[0].country_code | JP |
| authorships[9].institutions[0].display_name | Nippon Medical School |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Yuta Hasegawa |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[10].author.id | https://openalex.org/A5083034464 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Tadamichi Kawano |
| authorships[10].countries | JP |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[10].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[10].institutions[0].id | https://openalex.org/I80188885 |
| authorships[10].institutions[0].ror | https://ror.org/00krab219 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[10].institutions[0].country_code | JP |
| authorships[10].institutions[0].display_name | Nippon Medical School |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Tadamichi Kawano |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[11].author.id | https://openalex.org/A5057771677 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-3723-2967 |
| authorships[11].author.display_name | Hiroki Ono |
| authorships[11].countries | JP |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[11].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[11].institutions[0].id | https://openalex.org/I80188885 |
| authorships[11].institutions[0].ror | https://ror.org/00krab219 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[11].institutions[0].country_code | JP |
| authorships[11].institutions[0].display_name | Nippon Medical School |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Hiroki Ono |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[12].author.id | https://openalex.org/A5057069621 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-3302-3140 |
| authorships[12].author.display_name | Yūji Yoshida |
| authorships[12].countries | JP |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[12].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[12].institutions[0].id | https://openalex.org/I80188885 |
| authorships[12].institutions[0].ror | https://ror.org/00krab219 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[12].institutions[0].country_code | JP |
| authorships[12].institutions[0].display_name | Nippon Medical School |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Yuji Yoshida |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[13].author.id | https://openalex.org/A5049568375 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-1244-4736 |
| authorships[13].author.display_name | Tomomi Okubo |
| authorships[13].countries | JP |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[13].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[13].institutions[0].id | https://openalex.org/I80188885 |
| authorships[13].institutions[0].ror | https://ror.org/00krab219 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[13].institutions[0].country_code | JP |
| authorships[13].institutions[0].display_name | Nippon Medical School |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Tomomi Okubo |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[14].author.id | https://openalex.org/A5051628501 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Korenobu Hayama |
| authorships[14].countries | JP |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[14].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[14].institutions[0].id | https://openalex.org/I80188885 |
| authorships[14].institutions[0].ror | https://ror.org/00krab219 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[14].institutions[0].country_code | JP |
| authorships[14].institutions[0].display_name | Nippon Medical School |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Korenobu Hayama |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[15].author.id | https://openalex.org/A5004997283 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Ai Nakagawa‐Iwashita |
| authorships[15].countries | JP |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[15].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[15].institutions[0].id | https://openalex.org/I80188885 |
| authorships[15].institutions[0].ror | https://ror.org/00krab219 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[15].institutions[0].country_code | JP |
| authorships[15].institutions[0].display_name | Nippon Medical School |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Ai Nakagawa‐Iwashita |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[16].author.id | https://openalex.org/A5009103376 |
| authorships[16].author.orcid | https://orcid.org/0009-0002-2390-6692 |
| authorships[16].author.display_name | Norio Itokawa |
| authorships[16].countries | JP |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[16].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[16].institutions[0].id | https://openalex.org/I80188885 |
| authorships[16].institutions[0].ror | https://ror.org/00krab219 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[16].institutions[0].country_code | JP |
| authorships[16].institutions[0].display_name | Nippon Medical School |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Norio Itokawa |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[17].author.id | https://openalex.org/A5000519458 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Chisa Kondo |
| authorships[17].countries | JP |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[17].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[17].institutions[0].id | https://openalex.org/I80188885 |
| authorships[17].institutions[0].ror | https://ror.org/00krab219 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[17].institutions[0].country_code | JP |
| authorships[17].institutions[0].display_name | Nippon Medical School |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Chisa Kondo |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[18].author.id | https://openalex.org/A5080998573 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-6880-5161 |
| authorships[18].author.display_name | Mototsugu Nagao |
| authorships[18].countries | JP |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[18].affiliations[0].raw_affiliation_string | Division of Endocrinology, Diabetes and Metabolism Nippon Medical School Tokyo Japan |
| authorships[18].institutions[0].id | https://openalex.org/I80188885 |
| authorships[18].institutions[0].ror | https://ror.org/00krab219 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[18].institutions[0].country_code | JP |
| authorships[18].institutions[0].display_name | Nippon Medical School |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Mototsugu Nagao |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Division of Endocrinology, Diabetes and Metabolism Nippon Medical School Tokyo Japan |
| authorships[19].author.id | https://openalex.org/A5033830692 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-1930-9046 |
| authorships[19].author.display_name | Masato Iwabu |
| authorships[19].countries | JP |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[19].affiliations[0].raw_affiliation_string | Division of Endocrinology, Diabetes and Metabolism Nippon Medical School Tokyo Japan |
| authorships[19].institutions[0].id | https://openalex.org/I80188885 |
| authorships[19].institutions[0].ror | https://ror.org/00krab219 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[19].institutions[0].country_code | JP |
| authorships[19].institutions[0].display_name | Nippon Medical School |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Masato Iwabu |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Division of Endocrinology, Diabetes and Metabolism Nippon Medical School Tokyo Japan |
| authorships[20].author.id | https://openalex.org/A5058841198 |
| authorships[20].author.orcid | https://orcid.org/0000-0002-5558-6104 |
| authorships[20].author.display_name | Katsuhiko Iwakiri |
| authorships[20].countries | JP |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I80188885 |
| authorships[20].affiliations[0].raw_affiliation_string | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| authorships[20].institutions[0].id | https://openalex.org/I80188885 |
| authorships[20].institutions[0].ror | https://ror.org/00krab219 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I80188885 |
| authorships[20].institutions[0].country_code | JP |
| authorships[20].institutions[0].display_name | Nippon Medical School |
| authorships[20].author_position | last |
| authorships[20].raw_author_name | Katsuhiko Iwakiri |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Division of Gastroenterology and Hepatology Nippon Medical School Tokyo Japan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241 |
| open_access.oa_status | hybrid |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Effect of Tirzepatide Treatment on Hepatic Biomarkers in Patients With Metabolic Dysfunction‐Associated Steatotic Liver Disease and Type 2 Diabetes Mellitus |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10351 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Liver Disease Diagnosis and Treatment |
| related_works | https://openalex.org/W2994642861, https://openalex.org/W2109444927, https://openalex.org/W1991981123, https://openalex.org/W4294123679, https://openalex.org/W2419316219, https://openalex.org/W2382688610, https://openalex.org/W2151429631, https://openalex.org/W2883354468, https://openalex.org/W4285795411, https://openalex.org/W3176967935 |
| cited_by_count | 1 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| locations_count | 2 |
| best_oa_location.id | doi:10.1111/hepr.14241 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S110399111 |
| best_oa_location.source.issn | 1386-6346, 1872-034X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | 1386-6346 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Hepatology Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310320595 |
| best_oa_location.source.host_organization_name | Wiley |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| best_oa_location.license | cc-by-nc |
| best_oa_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Hepatology Research |
| best_oa_location.landing_page_url | https://doi.org/10.1111/hepr.14241 |
| primary_location.id | doi:10.1111/hepr.14241 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S110399111 |
| primary_location.source.issn | 1386-6346, 1872-034X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 1386-6346 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Hepatology Research |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | cc-by-nc |
| primary_location.pdf_url | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/hepr.14241 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Hepatology Research |
| primary_location.landing_page_url | https://doi.org/10.1111/hepr.14241 |
| publication_date | 2025-07-05 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2204688218, https://openalex.org/W2136795008, https://openalex.org/W3177122952, https://openalex.org/W3120106258, https://openalex.org/W4281934192, https://openalex.org/W3011482816, https://openalex.org/W6959806227, https://openalex.org/W4224295659, https://openalex.org/W4399461049, https://openalex.org/W4318923555, https://openalex.org/W4399435116, https://openalex.org/W1985442918, https://openalex.org/W1997425045, https://openalex.org/W2091106363, https://openalex.org/W3102426258, https://openalex.org/W3177393241, https://openalex.org/W2215535790, https://openalex.org/W4280579438, https://openalex.org/W3092264591, https://openalex.org/W4313568657, https://openalex.org/W2941033601, https://openalex.org/W4382050932 |
| referenced_works_count | 22 |
| abstract_inverted_index.( | 131, 147, 162 |
| abstract_inverted_index.2 | 16 |
| abstract_inverted_index.4 | 69 |
| abstract_inverted_index.= | 149, 164, 167 |
| abstract_inverted_index.a | 12, 61 |
| abstract_inverted_index.p | 118, 132, 151, 166, 202 |
| abstract_inverted_index.r | 148, 163 |
| abstract_inverted_index.(2 | 225 |
| abstract_inverted_index.(3 | 220 |
| abstract_inverted_index.(5 | 216 |
| abstract_inverted_index.12 | 104 |
| abstract_inverted_index.13 | 50 |
| abstract_inverted_index.16 | 37 |
| abstract_inverted_index.48 | 53, 129, 199 |
| abstract_inverted_index.IV | 178 |
| abstract_inverted_index.Of | 48 |
| abstract_inverted_index.as | 11 |
| abstract_inverted_index.at | 60, 102 |
| abstract_inverted_index.in | 20, 92, 136, 143, 158, 233 |
| abstract_inverted_index.mg | 65 |
| abstract_inverted_index.of | 9, 55, 63, 79, 171, 245 |
| abstract_inverted_index.on | 84 |
| abstract_inverted_index.to | 5, 76, 128, 198 |
| abstract_inverted_index.2.5 | 64 |
| abstract_inverted_index.7s, | 180 |
| abstract_inverted_index.A1c | 99 |
| abstract_inverted_index.Aim | 1 |
| abstract_inverted_index.The | 169 |
| abstract_inverted_index.and | 41, 71, 86, 97, 105, 189, 223, 241, 248, 251 |
| abstract_inverted_index.but | 154 |
| abstract_inverted_index.for | 14, 68, 174, 231 |
| abstract_inverted_index.not | 155 |
| abstract_inverted_index.the | 7, 77, 80, 109, 186, 190 |
| abstract_inverted_index.was | 58 |
| abstract_inverted_index.who | 43 |
| abstract_inverted_index.< | 119, 133, 152, 203 |
| abstract_inverted_index.(all | 117, 201 |
| abstract_inverted_index.Most | 205 |
| abstract_inverted_index.T2DM | 42, 232 |
| abstract_inverted_index.This | 2, 30 |
| abstract_inverted_index.Type | 15, 177 |
| abstract_inverted_index.Week | 103 |
| abstract_inverted_index.body | 93, 137, 253 |
| abstract_inverted_index.dose | 62, 72 |
| abstract_inverted_index.from | 126, 196 |
| abstract_inverted_index.left | 75 |
| abstract_inverted_index.once | 66 |
| abstract_inverted_index.were | 44, 74, 100, 106, 139, 208 |
| abstract_inverted_index.with | 22, 39, 46, 114, 141, 156, 235 |
| abstract_inverted_index.0.05) | 153 |
| abstract_inverted_index.0.45, | 165 |
| abstract_inverted_index.0.57, | 150 |
| abstract_inverted_index.1–2 | 211 |
| abstract_inverted_index.MASLD | 40, 236 |
| abstract_inverted_index.aimed | 4 |
| abstract_inverted_index.based | 83 |
| abstract_inverted_index.found | 101 |
| abstract_inverted_index.liver | 26, 95, 191, 239, 246 |
| abstract_inverted_index.pilot | 34 |
| abstract_inverted_index.study | 3, 35 |
| abstract_inverted_index.tests | 173 |
| abstract_inverted_index.weeks | 54, 130, 200 |
| abstract_inverted_index.(T2DM) | 19 |
| abstract_inverted_index.0.05). | 120, 134, 204 |
| abstract_inverted_index.0.12). | 168 |
| abstract_inverted_index.Grades | 210 |
| abstract_inverted_index.events | 207 |
| abstract_inverted_index.impact | 8 |
| abstract_inverted_index.index, | 188 |
| abstract_inverted_index.levels | 146 |
| abstract_inverted_index.nausea | 215 |
| abstract_inverted_index.period | 112 |
| abstract_inverted_index.these, | 49 |
| abstract_inverted_index.values | 116 |
| abstract_inverted_index.weekly | 67 |
| abstract_inverted_index.weeks, | 70 |
| abstract_inverted_index.weight | 138 |
| abstract_inverted_index.12.5%). | 227 |
| abstract_inverted_index.18.8%), | 222 |
| abstract_inverted_index.31.3%), | 218 |
| abstract_inverted_index.Changes | 135 |
| abstract_inverted_index.Methods | 29 |
| abstract_inverted_index.Results | 89 |
| abstract_inverted_index.adverse | 87, 206 |
| abstract_inverted_index.alanine | 144 |
| abstract_inverted_index.changes | 142, 157 |
| abstract_inverted_index.clarify | 6 |
| abstract_inverted_index.disease | 27 |
| abstract_inverted_index.events. | 88 |
| abstract_inverted_index.injury, | 242 |
| abstract_inverted_index.markers | 244 |
| abstract_inverted_index.reduced | 252 |
| abstract_inverted_index.results | 170 |
| abstract_inverted_index.status, | 250 |
| abstract_inverted_index.treated | 45 |
| abstract_inverted_index.weight, | 94 |
| abstract_inverted_index.weight. | 254 |
| abstract_inverted_index.(MASLD). | 28 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.Wisteria | 181 |
| abstract_inverted_index.baseline | 115, 127, 197 |
| abstract_inverted_index.collagen | 179 |
| abstract_inverted_index.compared | 113 |
| abstract_inverted_index.diabetes | 17, 249 |
| abstract_inverted_index.diarrhea | 219 |
| abstract_inverted_index.efficacy | 85 |
| abstract_inverted_index.enzymes, | 96 |
| abstract_inverted_index.improved | 238 |
| abstract_inverted_index.included | 36 |
| abstract_inverted_index.mellitus | 18 |
| abstract_inverted_index.patients | 21, 38, 51, 234 |
| abstract_inverted_index.protein, | 185 |
| abstract_inverted_index.48‐week | 110 |
| abstract_inverted_index.attending | 81 |
| abstract_inverted_index.completed | 52 |
| abstract_inverted_index.decreased | 125, 195 |
| abstract_inverted_index.fibrosis, | 175, 247 |
| abstract_inverted_index.including | 176, 214 |
| abstract_inverted_index.initiated | 59 |
| abstract_inverted_index.metabolic | 23 |
| abstract_inverted_index.parameter | 123, 161 |
| abstract_inverted_index.patients, | 217, 221, 226 |
| abstract_inverted_index.physician | 82 |
| abstract_inverted_index.steatosis | 240 |
| abstract_inverted_index.steatotic | 25 |
| abstract_inverted_index.stiffness | 192 |
| abstract_inverted_index.surrogate | 243 |
| abstract_inverted_index.sustained | 107 |
| abstract_inverted_index.symptoms, | 213 |
| abstract_inverted_index.transient | 209 |
| abstract_inverted_index.treatment | 13, 111, 230 |
| abstract_inverted_index.Controlled | 121 |
| abstract_inverted_index.controlled | 159 |
| abstract_inverted_index.correlated | 140 |
| abstract_inverted_index.discretion | 78 |
| abstract_inverted_index.floribunda | 182 |
| abstract_inverted_index.hemoglobin | 98 |
| abstract_inverted_index.throughout | 108 |
| abstract_inverted_index.treatment. | 56 |
| abstract_inverted_index.Conclusions | 228 |
| abstract_inverted_index.Significant | 90 |
| abstract_inverted_index.Tirzepatide | 57, 229 |
| abstract_inverted_index.adjustments | 73 |
| abstract_inverted_index.attenuation | 122, 160 |
| abstract_inverted_index.noninvasive | 172 |
| abstract_inverted_index.tirzepatide | 10 |
| abstract_inverted_index.constipation | 224 |
| abstract_inverted_index.fibrosis‐4 | 187 |
| abstract_inverted_index.improvements | 91 |
| abstract_inverted_index.measurement, | 193 |
| abstract_inverted_index.prospective, | 32 |
| abstract_inverted_index.tirzepatide. | 47 |
| abstract_inverted_index.observational | 33 |
| abstract_inverted_index.significantly | 124, 194, 237 |
| abstract_inverted_index.single‐arm, | 31 |
| abstract_inverted_index.aminotransferase | 145 |
| abstract_inverted_index.gastrointestinal | 212 |
| abstract_inverted_index.Mac‐2‐binding | 184 |
| abstract_inverted_index.agglutinin‐positive | 183 |
| abstract_inverted_index.dysfunction‐associated | 24 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 21 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8600000143051147 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.88966587 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |