Cell Reports Methods • Vol 3 • No 5
Effective and efficient neural networks for spike inference from in vivo calcium imaging
April 2023 • Zhanhong Zhou, Hei Matthew Yip, Katya Tsimring, Mriganka Sur, Jacque Pak Kan Ip, Chung Tin
Calcium imaging provides advantages in monitoring large populations of neuronal activities simultaneously. However, it lacks the signal quality provided by neural spike recording in traditional electrophysiology. To address this issue, we developed a supervised data-driven approach to extract spike information from calcium signals. We propose the ENS<sup>2</sup> (effective and efficient neural networks for spike inference from calcium signals) system for spike-rate and spike-event predictions using <i>ΔF</i>/<i>F<…