Effective inactivation of a wide range of viruses by pasteurization Article Swipe
Albrecht Gröner
,
Connie Broumis
,
Randel Fang
,
Thomas Nowak
,
Birgit Popp
,
Wolfram Schäfer
,
Nathan Roth
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/trf.14390
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1111/trf.14390
BACKGROUND Careful selection and testing of plasma reduces the risk of blood‐borne viruses in the starting material for plasma‐derived products. Furthermore, effective measures such as pasteurization at 60°C for 10 hours have been implemented in the manufacturing process of therapeutic plasma proteins such as human albumin, coagulation factors, immunoglobulins, and enzyme inhibitors to inactivate blood‐borne viruses of concern. A comprehensive compilation of the virus reduction capacity of pasteurization is presented including the effect of stabilizers used to protect the therapeutic protein from modifications during heat treatment. STUDY DESIGN AND METHODS The virus inactivation kinetics of pasteurization for a broad range of viruses were evaluated in the relevant intermediates from more than 15 different plasma manufacturing processes. Studies were carried out under the routine manufacturing target variables, such as temperature and product‐specific stabilizer composition. Additional studies were also performed under robustness conditions, that is, outside production specifications. RESULTS The data demonstrate that pasteurization inactivates a wide range of enveloped and nonenveloped viruses of diverse physicochemical characteristics. After a maximum of 6 hours' incubation, no residual infectivity could be detected for the majority of enveloped viruses. Effective inactivation of a range of nonenveloped viruses, with the exception of nonhuman parvoviruses, was documented. CONCLUSION Pasteurization is a very robust and reliable virus inactivation method with a broad effectiveness against known blood‐borne pathogens and emerging or potentially emerging viruses. Pasteurization has proven itself to be a highly effective step, in combination with other complementary safety measures, toward assuring the virus safety of final product.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/trf.14390
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.14390
- OA Status
- hybrid
- Cited By
- 42
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2768960215
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2768960215Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/trf.14390Digital Object Identifier
- Title
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Effective inactivation of a wide range of viruses by pasteurizationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2017Year of publication
- Publication date
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2017-11-16Full publication date if available
- Authors
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Albrecht Gröner, Connie Broumis, Randel Fang, Thomas Nowak, Birgit Popp, Wolfram Schäfer, Nathan RothList of authors in order
- Landing page
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https://doi.org/10.1111/trf.14390Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.14390Direct link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/trf.14390Direct OA link when available
- Concepts
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Pasteurization, Infectivity, Virus, Viral envelope, Virus inactivation, Virology, Blood product, Human albumin, Biology, Chemistry, Food science, Albumin, Medicine, Biochemistry, PathologyTop concepts (fields/topics) attached by OpenAlex
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42Total citation count in OpenAlex
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2025: 4, 2024: 5, 2023: 8, 2022: 4, 2021: 8Per-year citation counts (last 5 years)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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