Effectiveness and Safety of Two Consecutive Cycles of Single Embryo Transfer Compared With One Cycle of Double Embryo Transfer: A Systematic Review and Meta-Analysis Article Swipe
Yangqin Peng
,
Shujuan Ma
,
Liang Hu
,
Xiaojuan Wang
,
Yiquan Xiong
,
Minghong Yao
,
Jing Tan
,
Fei Gong
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2022.920973
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2022.920973
Objective To date, evidence regarding the effectiveness and safety of two consecutive cycles of single embryo transfer (2SETs) compared with one cycle of double embryo transfer (DET) has been inadequate, particularly considering infertile women with different prognostic factors. This study aimed to comprehensively summarize the evidence by comparing 2SETs with DET. Methods PubMed, Embase, Cochrane Library databases, ClinicalTrails.gov, and the WHO International Clinical Trials Registry Platform were searched up to March 22, 2022. Peer-reviewed, English-language randomized controlled trials (RCTs) and observational studies (OS) comparing the outcomes of 2SETs with DET in infertile women with their own oocytes and embryos were included. Two authors independently conducted study selection, data extraction, and bias assessment. The Mantel–Haenszel random-effects model was used for pooling RCTs, and a Bayesian design-adjusted model was conducted to synthesize the results from both RCTs and OS. Main Results Twelve studies were finally included. Compared with the DET, 2SETs were associated with a similar cumulative live birth rate (LBR; 48.24% vs. 48.91%; OR, 0.97; 95% credible interval (CrI), 0.89–1.13, τ 2 = 0.1796; four RCTs and six observational studies; 197,968 women) and a notable lower cumulative multiple birth rate (MBR; 0.87% vs. 17.72%; OR, 0.05; 95% CrI, 0.02–0.10, τ 2 = 0.1036; four RCTs and five observational studies; 197,804 women). Subgroup analyses revealed a significant increase in cumulative LBR (OR, 1.33; 95% CrI, 1.29–1.38, τ 2 = 0) after two consecutive cycles of single blastocyst transfer compared with one cycle of double blastocyst transfer. Moreover, a lower risk of cesarean section, antepartum hemorrhage, preterm birth, low birth weight, and neonatal intensive care unit admission but a higher gestational age at birth and birth weight were found in the 2SETs group. Conclusion Compared to the DET strategy, 2SETs result in a similar LBR while simultaneously reducing the MBR and improving maternal and neonatal adverse outcomes. The 2SETs strategy appears to be especially beneficial for women aged ≤35 years and for blastocyst transfers.
Related Topics
Concepts
Meta-analysis
Single Embryo Transfer
Embryo transfer
Embryo
Andrology
Biology
Medicine
Internal medicine
Cell biology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2022.920973
- https://www.frontiersin.org/articles/10.3389/fendo.2022.920973/pdf
- OA Status
- gold
- Cited By
- 7
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4283730343
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4283730343Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fendo.2022.920973Digital Object Identifier
- Title
-
Effectiveness and Safety of Two Consecutive Cycles of Single Embryo Transfer Compared With One Cycle of Double Embryo Transfer: A Systematic Review and Meta-AnalysisWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-06-30Full publication date if available
- Authors
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Yangqin Peng, Shujuan Ma, Liang Hu, Xiaojuan Wang, Yiquan Xiong, Minghong Yao, Jing Tan, Fei GongList of authors in order
- Landing page
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https://doi.org/10.3389/fendo.2022.920973Publisher landing page
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https://www.frontiersin.org/articles/10.3389/fendo.2022.920973/pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/articles/10.3389/fendo.2022.920973/pdfDirect OA link when available
- Concepts
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Meta-analysis, Single Embryo Transfer, Embryo transfer, Embryo, Andrology, Biology, Medicine, Internal medicine, Cell biologyTop concepts (fields/topics) attached by OpenAlex
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7Total citation count in OpenAlex
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2025: 4, 2024: 3Per-year citation counts (last 5 years)
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46Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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