Abstract Background Poor adherence to clinical guidelines and diagnostic uncertainty are key contributors to antibiotic overprescription, accelerating antimicrobial resistance—a major global health threat. We developed ePOCT+, a digital clinical decision support algorithm designed to assist primary care clinicians in the diagnostic process and therapeutic management of acutely ill children under 15 years of age. ePOCT+ integrates oxygen saturation and hemoglobin measurements to help detect severe illnesses, and th…