Effectiveness of the low‐density lipoprotein cholesterol goals in secondary cardiovascular prevention Article Swipe
Maria García-Gil
,
Lia Alves‐Cabratosa
,
Oriol Cunillera
,
Jordi Blanch
,
Ruth Martí‐Lluch
,
Anna Ponjoan
,
Francesc Ribas‐Aulinas
,
Èric Tornabell‐Noguera
,
Lluís Zacarías‐Pons
,
Gina Domínguez‐Armengol
,
Elizabeth Guzmán
,
Rafel Ramos
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/eci.14258
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1111/eci.14258
Background The effectiveness of statin treatment to reduce coronary events and mortality has been hardly examined considering goals of LDL‐C. We aimed to analyse such association in secondary cardiovascular prevention. Methods Retrospective cohort analysis of electronic health records from the SIDIAP database, Catalonia‐Spain. Recruitment period was from 2006 to 2017 and study period finished at the end of 2018. We included 54,175 people aged ≥35 years in cardiovascular secondary prevention starting statin treatment. We analysed the association of achieved LDL‐C goals after statin initiation with coronary heart disease and all‐cause mortality. Results Mean age was 69 years and 20,146 (37.2%) were women. Coronary heart disease occurred in 5687 (10.5%) participants, and 10,676 (19.7%) persons passed away. Median follow‐up lasted 5.7 years (interquartile range, 3.4–8.1). The coronary heart disease HRs (95% CI) for the LDL‐C goals of 70–100, <70–55 and <55 mg/dL were .86 (.81–.92), .83 (.76–.9) and .8 (.72–.88), respectively. They were .89 (.83–.96) in the group with 30%–40% reduction and .86 (.8–.93) in the groups with 40%–50% and ≥50% reduction. We observed no association with mortality. We observed no relevant differences by sex or age. Conclusions This population‐level retrospective analysis of real‐world data observed that treatment with statins is effective to achieve certain LDL‐C goals and CHD reduction. The lack of significant difference between LDL‐C goals needs confirmation in additional studies with real‐world data. The LDL‐C target should consider the magnitude of the decrease in coronary events.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/eci.14258
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.14258
- OA Status
- hybrid
- Cited By
- 3
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399298717
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- OpenAlex ID
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https://openalex.org/W4399298717Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/eci.14258Digital Object Identifier
- Title
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Effectiveness of the low‐density lipoprotein cholesterol goals in secondary cardiovascular preventionWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-06-03Full publication date if available
- Authors
-
Maria García-Gil, Lia Alves‐Cabratosa, Oriol Cunillera, Jordi Blanch, Ruth Martí‐Lluch, Anna Ponjoan, Francesc Ribas‐Aulinas, Èric Tornabell‐Noguera, Lluís Zacarías‐Pons, Gina Domínguez‐Armengol, Elizabeth Guzmán, Rafel RamosList of authors in order
- Landing page
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https://doi.org/10.1111/eci.14258Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.14258Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
- OA URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/eci.14258Direct OA link when available
- Concepts
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Medicine, Interquartile range, Statin, Retrospective cohort study, Internal medicine, Coronary heart disease, Secondary prevention, Cohort, Population, Cholesterol, Coronary artery disease, Cardiology, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3Per-year citation counts (last 5 years)
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35Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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