Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study Article Swipe
Sinibaldo Romero Arocha
,
Kim K Han
,
Rebecca D. Huffstutler
,
Geethika Thota
,
NATALIE A. MACHERET
,
Amber B. Courville
,
Robert J. Brychta
,
Kong Y. Chen
,
Stephanie T. Chung
,
Laura C. Coates
,
Alexander J. Clarke
,
Michael N. Sack
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2196/74999
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.2196/74999
Background Psoriasis is a chronic inflammatory disease associated with multiple comorbidities, including metabolic syndrome and cardiovascular disease. Although specific dietary interventions, such as intermittent fasting and caloric restriction, have been shown to ameliorate inflammation and promote weight loss, the effect of these interventions independent of weight loss remains unclear. Time-restricted eating (TRE), a type of intermittent fasting, limits the daily eating window to a fixed number of hours. Recent studies suggest TRE may improve immune function in individuals with metabolic syndrome and cardiovascular risk factors. A crucial advantage of TRE over other investigated dietary restriction strategies is its reported high adherence rate, making it a more feasible intervention for long-term use. Therefore, exploring the effects of TRE on metabolic and immunological parameters in psoriasis is warranted. Objective This study was designed to evaluate the effects of short-term, isocaloric TRE, independent of weight loss, on immune cell function and serum metabolite profiles of volunteers with mild-to-moderate psoriasis compared to healthy individuals. Methods This case-control, prospective study was performed on 10 healthy male participants and 10 age-, BMI-, and sex-matched individuals with mild-to-moderate psoriasis. All individuals with psoriasis had stable disease and were being treated with topical therapies without any exposure to immunomodulatory biologics. This study was conducted at the National Institutes of Health Clinical Center. Immune profiles, glucose handling, energy expenditure, and participants’ weights were assessed at baseline and after 3 days of TRE following a daily 6-hour eating window and 18-hour fast. Results The trial commenced in June 2021 and was completed in February 2023. A total of 20 participants were enrolled—10 with mild-to-moderate psoriasis and 10 age-, BMI-, and sex-matched healthy individuals. As of the time of manuscript submission, data processing is ongoing. Multiomic datasets, including gene expression, surface and intracellular protein levels, and metabolite profiles, are being generated from peripheral blood mononuclear cells, CD4+-enriched T-cells, and serum samples. The integrated bioinformatics analyses will be reported once the data analysis is completed. Conclusions This clinical protocol was designed to characterize the effects of short term (3-day) TRE on psoriasis, independent of weight loss, by comparing immune cell regulatory responses between healthy individuals and those with psoriasis. More specifically, we aim to map the molecular pathways activated by TRE and assess how they affect immune cell composition, activation, and metabolism. Additionally, components of the metabolic response to isocaloric TRE are being explored. Insights into how dietary interventions impact metabolism and the immune system will enhance our understanding of the pathogenesis of psoriasis and may reveal new therapeutic avenues for managing this inflammatory condition. Trial Registration ClinicalTrials.gov NCT04728165; https://clinicaltrials.gov/study/NCT04728165
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.2196/74999
- https://www.researchprotocols.org/2025/1/e74999/PDF
- OA Status
- gold
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413257731
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413257731Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.2196/74999Digital Object Identifier
- Title
-
Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-08-15Full publication date if available
- Authors
-
Sinibaldo Romero Arocha, Kim K Han, Rebecca D. Huffstutler, Geethika Thota, NATALIE A. MACHERET, Amber B. Courville, Robert J. Brychta, Kong Y. Chen, Stephanie T. Chung, Laura C. Coates, Alexander J. Clarke, Michael N. SackList of authors in order
- Landing page
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https://doi.org/10.2196/74999Publisher landing page
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https://www.researchprotocols.org/2025/1/e74999/PDFDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.researchprotocols.org/2025/1/e74999/PDFDirect OA link when available
- Concepts
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Psoriasis, Protocol (science), Medicine, Prospective cohort study, Inflammation, Psychology, Internal medicine, Immunology, Alternative medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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