Effects of Bifidobacterium animalis subsp. lactis Bl-04 on Skin Wrinkles and Dryness: A Randomized, Triple-Blinded, Placebo-Controlled Clinical Trial Article Swipe
Laura Huuskonen
,
Anna Lyra
,
Eun Ju Lee
,
Jahyun Ryu
,
Hyun-Jin Jeong
,
Ji Hwoon Baek
,
Youngkyoung Seo
,
Min Kyung Shin
,
Kirsti Tiihonen
,
Tommi Pesonen
,
Antti Lauerma
,
Jenni Reimari
,
Alvin Ibarra
,
Heli Anglenius
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/dermato2020005
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/dermato2020005
The effects of orally consumed probiotics on skin wrinkles and dryness are not fully known. A randomized, placebo-controlled, triple-blinded study was conducted with 148 healthy Korean female volunteers aged between 33 and 60 years, who were administered 1.75 × 109 colony-forming units (CFUs) of Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) (N = 74) or matching placebo (N = 74) for 12 weeks. Facial wrinkles (with 3-dimensional (3D) imaging), skin hydration, transepidermal water loss (TEWL), elasticity, and gloss were assessed at baseline and after every 4 weeks of the intervention. Questionnaire-based subjective evaluations of product efficacy and usability were also analyzed. The consumption of Bl-04 was safe and ameliorated significantly facial skin wrinkle parameters (total wrinkle area and volume, average depth of wrinkles, and arithmetic average roughness (Ra)) versus placebo at 4 weeks, but there were no differences at Week 8 or 12 between groups. Skin hydration, TEWL, elasticity, and gloss were similar between treatment groups, as were the subjective evaluation scores. Oral consumption of Bl-04 indicated promising short-term effects on skin appearance from the winter toward the spring. In future study designs, special attention should be paid to environmental conditions as well as to the skin condition and age of the participants.
Related Topics
Concepts
Transepidermal water loss
Wrinkle
Placebo
Medicine
Gloss (optics)
Bifidobacterium animalis
Randomized controlled trial
Bifidobacterium bifidum
Dermatology
Surgery
Bifidobacterium
Food science
Lactobacillus
Pathology
Biology
Chemistry
Gerontology
Alternative medicine
Stratum corneum
Fermentation
Coating
Organic chemistry
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/dermato2020005
- https://www.mdpi.com/2673-6179/2/2/5/pdf?version=1654569460
- OA Status
- diamond
- Cited By
- 3
- References
- 90
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4280615920
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4280615920Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/dermato2020005Digital Object Identifier
- Title
-
Effects of Bifidobacterium animalis subsp. lactis Bl-04 on Skin Wrinkles and Dryness: A Randomized, Triple-Blinded, Placebo-Controlled Clinical TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-18Full publication date if available
- Authors
-
Laura Huuskonen, Anna Lyra, Eun Ju Lee, Jahyun Ryu, Hyun-Jin Jeong, Ji Hwoon Baek, Youngkyoung Seo, Min Kyung Shin, Kirsti Tiihonen, Tommi Pesonen, Antti Lauerma, Jenni Reimari, Alvin Ibarra, Heli AngleniusList of authors in order
- Landing page
-
https://doi.org/10.3390/dermato2020005Publisher landing page
- PDF URL
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https://www.mdpi.com/2673-6179/2/2/5/pdf?version=1654569460Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2673-6179/2/2/5/pdf?version=1654569460Direct OA link when available
- Concepts
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Transepidermal water loss, Wrinkle, Placebo, Medicine, Gloss (optics), Bifidobacterium animalis, Randomized controlled trial, Bifidobacterium bifidum, Dermatology, Surgery, Bifidobacterium, Food science, Lactobacillus, Pathology, Biology, Chemistry, Gerontology, Alternative medicine, Stratum corneum, Fermentation, Coating, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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90Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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