Effects of Cranberry Juice Supplementation on Cardiovascular Disease Risk Factors in Adults with Elevated Blood Pressure: A Randomized Controlled Trial Article Swipe
YOU?
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· 2021
· Open Access
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· DOI: https://doi.org/10.3390/nu13082618
Emerging cardiovascular disease (CVD) risk factors, including central vascular function and HDL efflux, may be modifiable with food-based interventions such as cranberry juice. A randomized, placebo-controlled, crossover trial was conducted in middle-aged adults with overweight/obesity (n = 40; mean BMI: 28.7 ± 0.8 kg/m2; mean age: 47 ± 2 years) and elevated brachial blood pressure (mean systolic/diastolic BP: 124 ± 2/81 ± 1 mm Hg). Study participants consumed 500 mL/d of cranberry juice (~16 fl oz; 27% cranberry juice) or a matched placebo juice in a randomized order (8-week supplementation periods; 8-week compliance break), with blood samples and vascular measurements obtained at study entry and following each supplementation period. There was no significant treatment effect of cranberry juice supplementation on the primary endpoint of central systolic blood pressure or central or brachial diastolic pressure. Cranberry juice significantly reduced 24-h diastolic ambulatory BP by ~2 mm Hg compared to the placebo (p = 0.05) during daytime hours. Cranberry juice supplementation did not alter LDL-C but significantly changed the composition of the lipoprotein profile compared to the placebo, increasing the concentration of large LDL-C particles (+29.5 vs. −6.7 nmol/L; p = 0.02) and LDL size (+0.073 vs. −0.068 nm; p = 0.001). There was no effect of treatment on ex vivo HDL efflux in the total population, but exploratory subgroup analyses identified an interaction between BMI and global HDL efflux (p = 0.02), with greater effect of cranberry juice in participants who were overweight. Exploratory analyses indicate that baseline C-reactive protein (CRP) values may moderate treatment effects. In this population of adults with elevated blood pressure, cranberry juice supplementation had no significant effect on central systolic blood pressure but did have modest effects on 24-h diastolic ambulatory BP and the lipoprotein profile. Future studies are needed to verify these findings and the results of our exploratory analyses related to baseline health moderators.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu13082618
- https://www.mdpi.com/2072-6643/13/8/2618/pdf?version=1627972772
- OA Status
- gold
- Cited By
- 22
- References
- 70
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3190727859
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3190727859Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu13082618Digital Object Identifier
- Title
-
Effects of Cranberry Juice Supplementation on Cardiovascular Disease Risk Factors in Adults with Elevated Blood Pressure: A Randomized Controlled TrialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-07-29Full publication date if available
- Authors
-
Chesney K. Richter, Ann C. Skulas‐Ray, Trent Gaugler, Stacey Meily, Kristina Petersen, Penny M. Kris‐EthertonList of authors in order
- Landing page
-
https://doi.org/10.3390/nu13082618Publisher landing page
- PDF URL
-
https://www.mdpi.com/2072-6643/13/8/2618/pdf?version=1627972772Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2072-6643/13/8/2618/pdf?version=1627972772Direct OA link when available
- Concepts
-
CRANBERRY JUICE, Placebo, Blood pressure, Medicine, Crossover study, Ambulatory blood pressure, Overweight, Internal medicine, Population, Randomized controlled trial, Diastole, Obesity, Urinary system, Pathology, Alternative medicine, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
22Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 5, 2023: 7, 2022: 5Per-year citation counts (last 5 years)
- References (count)
-
70Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(mean | 55 |
| abstract_inverted_index.0.02) | 189 |
| abstract_inverted_index.0.05) | 152 |
| abstract_inverted_index.LDL-C | 162, 181 |
| abstract_inverted_index.Study | 65 |
| abstract_inverted_index.There | 109, 200 |
| abstract_inverted_index.alter | 161 |
| abstract_inverted_index.blood | 53, 95, 126, 262, 274 |
| abstract_inverted_index.entry | 103 |
| abstract_inverted_index.juice | 72, 83, 117, 135, 157, 236, 265 |
| abstract_inverted_index.large | 180 |
| abstract_inverted_index.order | 87 |
| abstract_inverted_index.study | 102 |
| abstract_inverted_index.these | 296 |
| abstract_inverted_index.total | 213 |
| abstract_inverted_index.trial | 27 |
| abstract_inverted_index.(+29.5 | 183 |
| abstract_inverted_index.0.02), | 230 |
| abstract_inverted_index.8-week | 91 |
| abstract_inverted_index.Future | 290 |
| abstract_inverted_index.adults | 32, 259 |
| abstract_inverted_index.during | 153 |
| abstract_inverted_index.effect | 114, 203, 233, 270 |
| abstract_inverted_index.efflux | 210, 227 |
| abstract_inverted_index.global | 225 |
| abstract_inverted_index.health | 308 |
| abstract_inverted_index.hours. | 155 |
| abstract_inverted_index.juice) | 78 |
| abstract_inverted_index.juice. | 22 |
| abstract_inverted_index.kg/m2; | 43 |
| abstract_inverted_index.modest | 279 |
| abstract_inverted_index.needed | 293 |
| abstract_inverted_index.values | 250 |
| abstract_inverted_index.verify | 295 |
| abstract_inverted_index.years) | 49 |
| abstract_inverted_index.−6.7 | 185 |
| abstract_inverted_index.(+0.073 | 193 |
| abstract_inverted_index.(8-week | 88 |
| abstract_inverted_index.0.001). | 199 |
| abstract_inverted_index.between | 222 |
| abstract_inverted_index.break), | 93 |
| abstract_inverted_index.central | 7, 124, 129, 272 |
| abstract_inverted_index.changed | 165 |
| abstract_inverted_index.daytime | 154 |
| abstract_inverted_index.disease | 2 |
| abstract_inverted_index.effects | 280 |
| abstract_inverted_index.efflux, | 12 |
| abstract_inverted_index.greater | 232 |
| abstract_inverted_index.matched | 81 |
| abstract_inverted_index.nmol/L; | 186 |
| abstract_inverted_index.period. | 108 |
| abstract_inverted_index.placebo | 82, 149 |
| abstract_inverted_index.primary | 121 |
| abstract_inverted_index.profile | 171 |
| abstract_inverted_index.protein | 248 |
| abstract_inverted_index.reduced | 137 |
| abstract_inverted_index.related | 305 |
| abstract_inverted_index.results | 300 |
| abstract_inverted_index.samples | 96 |
| abstract_inverted_index.studies | 291 |
| abstract_inverted_index.Emerging | 0 |
| abstract_inverted_index.analyses | 218, 243, 304 |
| abstract_inverted_index.baseline | 246, 307 |
| abstract_inverted_index.brachial | 52, 131 |
| abstract_inverted_index.compared | 146, 172 |
| abstract_inverted_index.consumed | 67 |
| abstract_inverted_index.effects. | 254 |
| abstract_inverted_index.elevated | 51, 261 |
| abstract_inverted_index.endpoint | 122 |
| abstract_inverted_index.factors, | 5 |
| abstract_inverted_index.findings | 297 |
| abstract_inverted_index.function | 9 |
| abstract_inverted_index.indicate | 244 |
| abstract_inverted_index.moderate | 252 |
| abstract_inverted_index.obtained | 100 |
| abstract_inverted_index.periods; | 90 |
| abstract_inverted_index.placebo, | 175 |
| abstract_inverted_index.pressure | 54, 127, 275 |
| abstract_inverted_index.profile. | 289 |
| abstract_inverted_index.subgroup | 217 |
| abstract_inverted_index.systolic | 125, 273 |
| abstract_inverted_index.vascular | 8, 98 |
| abstract_inverted_index.−0.068 | 195 |
| abstract_inverted_index.Cranberry | 134, 156 |
| abstract_inverted_index.conducted | 29 |
| abstract_inverted_index.cranberry | 21, 71, 77, 116, 235, 264 |
| abstract_inverted_index.crossover | 26 |
| abstract_inverted_index.diastolic | 132, 139, 283 |
| abstract_inverted_index.following | 105 |
| abstract_inverted_index.including | 6 |
| abstract_inverted_index.particles | 182 |
| abstract_inverted_index.pressure, | 263 |
| abstract_inverted_index.pressure. | 133 |
| abstract_inverted_index.treatment | 113, 205, 253 |
| abstract_inverted_index.C-reactive | 247 |
| abstract_inverted_index.ambulatory | 140, 284 |
| abstract_inverted_index.compliance | 92 |
| abstract_inverted_index.food-based | 17 |
| abstract_inverted_index.identified | 219 |
| abstract_inverted_index.increasing | 176 |
| abstract_inverted_index.modifiable | 15 |
| abstract_inverted_index.population | 257 |
| abstract_inverted_index.randomized | 86 |
| abstract_inverted_index.Exploratory | 242 |
| abstract_inverted_index.composition | 167 |
| abstract_inverted_index.exploratory | 216, 303 |
| abstract_inverted_index.interaction | 221 |
| abstract_inverted_index.lipoprotein | 170, 288 |
| abstract_inverted_index.middle-aged | 31 |
| abstract_inverted_index.moderators. | 309 |
| abstract_inverted_index.overweight. | 241 |
| abstract_inverted_index.population, | 214 |
| abstract_inverted_index.randomized, | 24 |
| abstract_inverted_index.significant | 112, 269 |
| abstract_inverted_index.measurements | 99 |
| abstract_inverted_index.participants | 66, 238 |
| abstract_inverted_index.concentration | 178 |
| abstract_inverted_index.interventions | 18 |
| abstract_inverted_index.significantly | 136, 164 |
| abstract_inverted_index.cardiovascular | 1 |
| abstract_inverted_index.supplementation | 89, 107, 118, 158, 266 |
| abstract_inverted_index.overweight/obesity | 34 |
| abstract_inverted_index.systolic/diastolic | 56 |
| abstract_inverted_index.placebo-controlled, | 25 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5060298323 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I130769515 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/2 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Zero hunger |
| citation_normalized_percentile.value | 0.91429391 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |