Effects of Inhibiting the Expression of Chitin Synthase Gene SfCHSB on the Metabolism of Trehalose and Chitin in Spodoptera frugiperda Larvae Article Swipe
Xiangyu Liu
,
Shasha Wang
,
Yuanyi Yu
,
Yisha Cheng
,
Chaoxing Hu
,
Min Zhou
,
Can Li
,
Bin Tang
,
Yan Wu
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/agriculture12122019
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/agriculture12122019
Spodoptera frugiperda is one of the world’s major agricultural pests and it occurs in many countries around the world. In Lepidoptera, the peritrophic membrane in the midgut protects the midgut epithelial cells and facilitates the digestion and absorption of food. Its main components are chitin and protein. Chitin synthase (CHS), as the last enzyme in the chitin biosynthesis pathway, is very important. Here, the expression of chitin synthase B (CHSB) gene identified from midgut was inhibited by RNA interference to explore its function in the metabolism of trehalose and chitin of S. frugiperda larvae. The results were as follows: SfCHSB was highly expressed in actively feeding larvae. Second, knockdown of SfCHSB resulted in decreased expression of most genes involved in chitin metabolism, including chitinase, and abnormal phenotypes of S. frugiperda were observed. In addition, membrane-bound trehalase activity and glucose content increased, and trehalose content decreased at 24 h after dsSfCHSB injection. Trehalase activities increased significantly and the glycogen content decreased at 48 h after dsSfCHSB injection. Finally, the activity of chitinase decreased and the content of chitin increased significantly. Our results indicate that SfCHSB expression is specific, SfCHSB has a large role in regulating chitin metabolism, and it has broad application prospects in the biocontrol of S. frugiperda.
Related Topics
Concepts
Chitin
Trehalase
Midgut
Chitin synthase
Chitinase
Spodoptera
Trehalose
Biochemistry
Biology
Enzyme
Microbiology
Botany
Gene
Larva
Chitosan
Recombinant DNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/agriculture12122019
- https://www.mdpi.com/2077-0472/12/12/2019/pdf?version=1669459214
- OA Status
- gold
- Cited By
- 7
- References
- 72
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310213281
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310213281Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/agriculture12122019Digital Object Identifier
- Title
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Effects of Inhibiting the Expression of Chitin Synthase Gene SfCHSB on the Metabolism of Trehalose and Chitin in Spodoptera frugiperda LarvaeWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-26Full publication date if available
- Authors
-
Xiangyu Liu, Shasha Wang, Yuanyi Yu, Yisha Cheng, Chaoxing Hu, Min Zhou, Can Li, Bin Tang, Yan WuList of authors in order
- Landing page
-
https://doi.org/10.3390/agriculture12122019Publisher landing page
- PDF URL
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https://www.mdpi.com/2077-0472/12/12/2019/pdf?version=1669459214Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2077-0472/12/12/2019/pdf?version=1669459214Direct OA link when available
- Concepts
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Chitin, Trehalase, Midgut, Chitin synthase, Chitinase, Spodoptera, Trehalose, Biochemistry, Biology, Enzyme, Microbiology, Botany, Gene, Larva, Chitosan, Recombinant DNATop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 3, 2023: 3Per-year citation counts (last 5 years)
- References (count)
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72Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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