Effects of linalool on extinction of mouse operant behaviour Article Swipe
David Shaw
,
Kelly Norwood
,
Paul Kennedy
,
Julian C. Leslie
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/fbp.0000000000000511
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1097/fbp.0000000000000511
Linalool is an enanitomer monoterpene compound identified as the pharmacologically active constituent in a number of essential oils and has been reported to display anxiolytic properties in humans and in animal models and to exert both GABAergic and glutamatergic effects. In Experiment 1 linalool (100, 200, and 300, i.p.) had no significant effects compared with saline in an activity tracker with C57BL/6j mice. Experiment 2 assessed the effects on operant extinction with mice of chlordiazepoxide at a dose (15 mg/kg, i.p.) previously shown to facilitate extinction, and the same doses of linalool, compared with saline. Linalool had a dose-related facilitatory effect on extinction. While the effects of the highest dose of linalool most closely resembled the effects of chlordiazepoxide, the pattern of results suggested that linalool may affect both the acquisition of extinction learning, which is influenced by glutamatergic processes, and the expression of extinction, known to be affected by GABAergic agents such as chlordiazepoxide.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/fbp.0000000000000511
- OA Status
- green
- Cited By
- 4
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2980828346
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W2980828346Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/fbp.0000000000000511Digital Object Identifier
- Title
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Effects of linalool on extinction of mouse operant behaviourWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-10-17Full publication date if available
- Authors
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David Shaw, Kelly Norwood, Paul Kennedy, Julian C. LeslieList of authors in order
- Landing page
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https://doi.org/10.1097/fbp.0000000000000511Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://pure.ulster.ac.uk/en/publications/c6a0275a-37ea-44ff-a08a-94c60dec0638Direct OA link when available
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Chlordiazepoxide, Linalool, Extinction (optical mineralogy), Chemistry, Saline, Pharmacology, Biology, Endocrinology, Chromatography, Diazepam, Essential oil, MineralogyTop concepts (fields/topics) attached by OpenAlex
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4Total citation count in OpenAlex
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2025: 2, 2021: 2Per-year citation counts (last 5 years)
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63Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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