Effects of pioglitazone on electrocardiogram parameters and heart rate variability in isoproterenol- induced cardiac ischemia in rat Article Swipe
Maryam Farokhipour
,
Amirreza Dehghanian
,
Hossein Fatemikia
,
Farzaneh Ketabchi
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3153033/v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3153033/v1
Background In this study, we aimed to determine whether short-term treatment with PPAR-γ agonist pioglitazone could influence electrocardiogram (ECG) parameters and heart rate variability (HRV) in isoproterenol-induced cardiac ischemia at rest and after phenylephrine injection. Methods Male Sprague-Dawley rats were divided into Sham, pioglitazone (PIO, 3 mg/kg, i.p.), isoproterenol-induced cardiac ischemia (ISO, 150 mg/kg, subcutaneously at 24-hour intervals on days 4 and 5), and PIO + ISO groups. Saline (in the Sham and ISO groups) or pioglitazone (in the PIO and PIO + ISO groups) were administered for 5 days. On day 6, tracheostomy and cannulation of the femoral artery and vein were performed under deep anesthesia. Then, blood pressure (BP) and ECG were recorded and HRV analysed. Results Baroreflex induced by intravenous injection of phenylephrine (10 µg/0.1 ml) increased BP and decreased heart rate (HR) in all groups. HR, QT interval, and QTc in the ISO group were more than in the Sham group at baseline and in baroreflex. Pioglitazone decreased the mentioned parameters in the PIO + ISO group. HRV analysis showed reductions in parasympathetic components of HRV in the ISO group, whereas pioglitazone corrected it in the PIO + ISO group. Cardiac markers, malondialdehyde, white blood cells, and heart/body weight ratio were more in the ISO group than those in the Sham group. All mentioned parameters were lower in the PIO + ISO group than those in the ISO group. Conclusion We indicated pioglitazone improves the electrical conduction of the heart and HRV in cardiac ischemia through modulating the inflammatory reactions.
Related Topics
Concepts
Pioglitazone
Medicine
Heart rate
Phenylephrine
Internal medicine
Heart rate variability
Anesthesia
Cardiology
Baroreflex
Agonist
Ischemia
QT interval
Blood pressure
Saline
Endocrinology
Diabetes mellitus
Type 2 diabetes
Receptor
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3153033/v1
- https://www.researchsquare.com/article/rs-3153033/latest.pdf
- OA Status
- green
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4384297923
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4384297923Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.21203/rs.3.rs-3153033/v1Digital Object Identifier
- Title
-
Effects of pioglitazone on electrocardiogram parameters and heart rate variability in isoproterenol- induced cardiac ischemia in ratWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-07-14Full publication date if available
- Authors
-
Maryam Farokhipour, Amirreza Dehghanian, Hossein Fatemikia, Farzaneh KetabchiList of authors in order
- Landing page
-
https://doi.org/10.21203/rs.3.rs-3153033/v1Publisher landing page
- PDF URL
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https://www.researchsquare.com/article/rs-3153033/latest.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
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https://www.researchsquare.com/article/rs-3153033/latest.pdfDirect OA link when available
- Concepts
-
Pioglitazone, Medicine, Heart rate, Phenylephrine, Internal medicine, Heart rate variability, Anesthesia, Cardiology, Baroreflex, Agonist, Ischemia, QT interval, Blood pressure, Saline, Endocrinology, Diabetes mellitus, Type 2 diabetes, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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56Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| primary_location.landing_page_url | https://doi.org/10.21203/rs.3.rs-3153033/v1 |
| publication_date | 2023-07-14 |
| publication_year | 2023 |
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