Effects of Soy Protein on Liver and Adipose Tissue Inflammation and Gut Microbiota in Mice Fed with Ketogenic Diets Article Swipe
Weide Li
,
I-Ting Wu
,
Wan-Ju Yeh
,
Wen‐Chih Huang
,
Hsin‐Yi Yang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/nu17152428
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/nu17152428
Background: Studies on ketogenic diets with a higher percentage of fat composition have revealed conflicting results regarding the modulation of lipid metabolism and tissue inflammation. Furthermore, studies on soy protein consumption in ketogenic diets remain limited. In this study, the effects of ketogenic diets on hepatic and adipose tissue inflammation and of soy protein replacement in ketogenic diets were investigated. Methods: Mice were randomly assigned to a control diet (C), ketogenic diet (KD), or ketogenic with soy protein (KS) groups for an 18-week experiment. Both ketogenic diet groups were fed a low-carbohydrate, high-fat diet during the first 12 weeks and a ketogenic diet during the last 6 weeks of the experiment. The KS group was fed the same diet as the KD group, but soy protein was substituted for casein during the last 6 weeks. Results: The KD and KS groups exhibited higher plasma β-hydroxybutyrate levels; a higher incidence of hyperlipidemia; and lower blood glucose, mesenteric fat mass, adipose tissue TNF-α, IL-1β levels, and NLRP3 protein expression compared with the C group. In the gut microbiota analysis, the KD group had a higher F-B ratio than the C group. Greater A. muciniphila abundance and a lower F-B ratio were noted in the KS group compared with the KD group. Conclusions: Although ketogenic diets decreased mesenteric fat mass and adipose tissue inflammation and modulated NLRP3 expression, they were associated with hepatic inflammation and gut dysbiosis. Soy protein consumption in a ketogenic diet did not differ from casein consumption regarding diet-induced tissue inflammation, but it may have altered the gut microbiota.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/nu17152428
- OA Status
- gold
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412711618
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4412711618Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/nu17152428Digital Object Identifier
- Title
-
Effects of Soy Protein on Liver and Adipose Tissue Inflammation and Gut Microbiota in Mice Fed with Ketogenic DietsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-25Full publication date if available
- Authors
-
Weide Li, I-Ting Wu, Wan-Ju Yeh, Wen‐Chih Huang, Hsin‐Yi YangList of authors in order
- Landing page
-
https://doi.org/10.3390/nu17152428Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/nu17152428Direct OA link when available
- Concepts
-
Ketogenic diet, Internal medicine, Endocrinology, Adipose tissue, Inflammation, Soy protein, Ketosis, Biology, Medicine, Food science, Diabetes mellitus, Neuroscience, EpilepsyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4412711618 |
|---|---|
| doi | https://doi.org/10.3390/nu17152428 |
| ids.doi | https://doi.org/10.3390/nu17152428 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40806013 |
| ids.openalex | https://openalex.org/W4412711618 |
| fwci | 0.0 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000818 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Animals |
| mesh[1].qualifier_ui | Q000494 |
| mesh[1].descriptor_ui | D030262 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | pharmacology |
| mesh[1].descriptor_name | Soybean Proteins |
| mesh[2].qualifier_ui | Q000008 |
| mesh[2].descriptor_ui | D030262 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | administration & dosage |
| mesh[2].descriptor_name | Soybean Proteins |
| mesh[3].qualifier_ui | Q000009 |
| mesh[3].descriptor_ui | D055423 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | adverse effects |
| mesh[3].descriptor_name | Diet, Ketogenic |
| mesh[4].qualifier_ui | Q000187 |
| mesh[4].descriptor_ui | D000069196 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | drug effects |
| mesh[4].descriptor_name | Gastrointestinal Microbiome |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D008099 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Liver |
| mesh[6].qualifier_ui | Q000187 |
| mesh[6].descriptor_ui | D008099 |
| mesh[6].is_major_topic | True |
| mesh[6].qualifier_name | drug effects |
| mesh[6].descriptor_name | Liver |
| mesh[7].qualifier_ui | Q000473 |
| mesh[7].descriptor_ui | D008099 |
| mesh[7].is_major_topic | True |
| mesh[7].qualifier_name | pathology |
| mesh[7].descriptor_name | Liver |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D051379 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Mice |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D000273 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Adipose Tissue |
| mesh[10].qualifier_ui | Q000187 |
| mesh[10].descriptor_ui | D000273 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | drug effects |
| mesh[10].descriptor_name | Adipose Tissue |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008297 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Male |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D007249 |
| mesh[12].is_major_topic | True |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Inflammation |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D008810 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Mice, Inbred C57BL |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D000071199 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | NLR Family, Pyrin Domain-Containing 3 Protein |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D059305 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Diet, High-Fat |
| mesh[16].qualifier_ui | Q000097 |
| mesh[16].descriptor_ui | D020155 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | blood |
| mesh[16].descriptor_name | 3-Hydroxybutyric Acid |
| mesh[17].qualifier_ui | Q000378 |
| mesh[17].descriptor_ui | D001786 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | metabolism |
| mesh[17].descriptor_name | Blood Glucose |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D000818 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | Animals |
| mesh[19].qualifier_ui | Q000494 |
| mesh[19].descriptor_ui | D030262 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | pharmacology |
| mesh[19].descriptor_name | Soybean Proteins |
| mesh[20].qualifier_ui | Q000008 |
| mesh[20].descriptor_ui | D030262 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | administration & dosage |
| mesh[20].descriptor_name | Soybean Proteins |
| mesh[21].qualifier_ui | Q000009 |
| mesh[21].descriptor_ui | D055423 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | adverse effects |
| mesh[21].descriptor_name | Diet, Ketogenic |
| mesh[22].qualifier_ui | Q000187 |
| mesh[22].descriptor_ui | D000069196 |
| mesh[22].is_major_topic | True |
| mesh[22].qualifier_name | drug effects |
| mesh[22].descriptor_name | Gastrointestinal Microbiome |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D008099 |
| mesh[23].is_major_topic | True |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | Liver |
| mesh[24].qualifier_ui | Q000187 |
| mesh[24].descriptor_ui | D008099 |
| mesh[24].is_major_topic | True |
| mesh[24].qualifier_name | drug effects |
| mesh[24].descriptor_name | Liver |
| mesh[25].qualifier_ui | Q000473 |
| mesh[25].descriptor_ui | D008099 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | pathology |
| mesh[25].descriptor_name | Liver |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D051379 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Mice |
| mesh[27].qualifier_ui | Q000378 |
| mesh[27].descriptor_ui | D000273 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | metabolism |
| mesh[27].descriptor_name | Adipose Tissue |
| mesh[28].qualifier_ui | Q000187 |
| mesh[28].descriptor_ui | D000273 |
| mesh[28].is_major_topic | True |
| mesh[28].qualifier_name | drug effects |
| mesh[28].descriptor_name | Adipose Tissue |
| mesh[29].qualifier_ui | |
| mesh[29].descriptor_ui | D008297 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | |
| mesh[29].descriptor_name | Male |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D007249 |
| mesh[30].is_major_topic | True |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Inflammation |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D008810 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Mice, Inbred C57BL |
| mesh[32].qualifier_ui | Q000378 |
| mesh[32].descriptor_ui | D000071199 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | metabolism |
| mesh[32].descriptor_name | NLR Family, Pyrin Domain-Containing 3 Protein |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D059305 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Diet, High-Fat |
| mesh[34].qualifier_ui | Q000097 |
| mesh[34].descriptor_ui | D020155 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | blood |
| mesh[34].descriptor_name | 3-Hydroxybutyric Acid |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D001786 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | Blood Glucose |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D000818 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Animals |
| mesh[37].qualifier_ui | Q000494 |
| mesh[37].descriptor_ui | D030262 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pharmacology |
| mesh[37].descriptor_name | Soybean Proteins |
| mesh[38].qualifier_ui | Q000008 |
| mesh[38].descriptor_ui | D030262 |
| mesh[38].is_major_topic | True |
| mesh[38].qualifier_name | administration & dosage |
| mesh[38].descriptor_name | Soybean Proteins |
| mesh[39].qualifier_ui | Q000009 |
| mesh[39].descriptor_ui | D055423 |
| mesh[39].is_major_topic | True |
| mesh[39].qualifier_name | adverse effects |
| mesh[39].descriptor_name | Diet, Ketogenic |
| mesh[40].qualifier_ui | Q000187 |
| mesh[40].descriptor_ui | D000069196 |
| mesh[40].is_major_topic | True |
| mesh[40].qualifier_name | drug effects |
| mesh[40].descriptor_name | Gastrointestinal Microbiome |
| mesh[41].qualifier_ui | Q000378 |
| mesh[41].descriptor_ui | D008099 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | metabolism |
| mesh[41].descriptor_name | Liver |
| mesh[42].qualifier_ui | Q000187 |
| mesh[42].descriptor_ui | D008099 |
| mesh[42].is_major_topic | True |
| mesh[42].qualifier_name | drug effects |
| mesh[42].descriptor_name | Liver |
| mesh[43].qualifier_ui | Q000473 |
| mesh[43].descriptor_ui | D008099 |
| mesh[43].is_major_topic | True |
| mesh[43].qualifier_name | pathology |
| mesh[43].descriptor_name | Liver |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D051379 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Mice |
| mesh[45].qualifier_ui | Q000378 |
| mesh[45].descriptor_ui | D000273 |
| mesh[45].is_major_topic | True |
| mesh[45].qualifier_name | metabolism |
| mesh[45].descriptor_name | Adipose Tissue |
| mesh[46].qualifier_ui | Q000187 |
| mesh[46].descriptor_ui | D000273 |
| mesh[46].is_major_topic | True |
| mesh[46].qualifier_name | drug effects |
| mesh[46].descriptor_name | Adipose Tissue |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D008297 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Male |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D007249 |
| mesh[48].is_major_topic | True |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Inflammation |
| mesh[49].qualifier_ui | |
| mesh[49].descriptor_ui | D008810 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | |
| mesh[49].descriptor_name | Mice, Inbred C57BL |
| type | article |
| title | Effects of Soy Protein on Liver and Adipose Tissue Inflammation and Gut Microbiota in Mice Fed with Ketogenic Diets |
| biblio.issue | 15 |
| biblio.volume | 17 |
| biblio.last_page | 2428 |
| biblio.first_page | 2428 |
| topics[0].id | https://openalex.org/T12267 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2737 |
| topics[0].subfield.display_name | Physiology |
| topics[0].display_name | Diet and metabolism studies |
| topics[1].id | https://openalex.org/T12964 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.996399998664856 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2712 |
| topics[1].subfield.display_name | Endocrinology, Diabetes and Metabolism |
| topics[1].display_name | Diet, Metabolism, and Disease |
| topics[2].id | https://openalex.org/T10866 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9914000034332275 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2739 |
| topics[2].subfield.display_name | Public Health, Environmental and Occupational Health |
| topics[2].display_name | Nutritional Studies and Diet |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2815 |
| concepts[0].id | https://openalex.org/C2778587478 |
| concepts[0].level | 3 |
| concepts[0].score | 0.9558635950088501 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1070684 |
| concepts[0].display_name | Ketogenic diet |
| concepts[1].id | https://openalex.org/C126322002 |
| concepts[1].level | 1 |
| concepts[1].score | 0.7483223080635071 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[1].display_name | Internal medicine |
| concepts[2].id | https://openalex.org/C134018914 |
| concepts[2].level | 1 |
| concepts[2].score | 0.7323244214057922 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[2].display_name | Endocrinology |
| concepts[3].id | https://openalex.org/C171089720 |
| concepts[3].level | 2 |
| concepts[3].score | 0.6901392936706543 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q193583 |
| concepts[3].display_name | Adipose tissue |
| concepts[4].id | https://openalex.org/C2776914184 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5501433610916138 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[4].display_name | Inflammation |
| concepts[5].id | https://openalex.org/C2777014122 |
| concepts[5].level | 2 |
| concepts[5].score | 0.5351406335830688 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7571993 |
| concepts[5].display_name | Soy protein |
| concepts[6].id | https://openalex.org/C2776731943 |
| concepts[6].level | 3 |
| concepts[6].score | 0.48660552501678467 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q1123139 |
| concepts[6].display_name | Ketosis |
| concepts[7].id | https://openalex.org/C86803240 |
| concepts[7].level | 0 |
| concepts[7].score | 0.36154547333717346 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[7].display_name | Biology |
| concepts[8].id | https://openalex.org/C71924100 |
| concepts[8].level | 0 |
| concepts[8].score | 0.33453619480133057 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[8].display_name | Medicine |
| concepts[9].id | https://openalex.org/C31903555 |
| concepts[9].level | 1 |
| concepts[9].score | 0.13732397556304932 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1637030 |
| concepts[9].display_name | Food science |
| concepts[10].id | https://openalex.org/C555293320 |
| concepts[10].level | 2 |
| concepts[10].score | 0.07793769240379333 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[10].display_name | Diabetes mellitus |
| concepts[11].id | https://openalex.org/C169760540 |
| concepts[11].level | 1 |
| concepts[11].score | 0.0 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q207011 |
| concepts[11].display_name | Neuroscience |
| concepts[12].id | https://openalex.org/C2778186239 |
| concepts[12].level | 2 |
| concepts[12].score | 0.0 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q41571 |
| concepts[12].display_name | Epilepsy |
| keywords[0].id | https://openalex.org/keywords/ketogenic-diet |
| keywords[0].score | 0.9558635950088501 |
| keywords[0].display_name | Ketogenic diet |
| keywords[1].id | https://openalex.org/keywords/internal-medicine |
| keywords[1].score | 0.7483223080635071 |
| keywords[1].display_name | Internal medicine |
| keywords[2].id | https://openalex.org/keywords/endocrinology |
| keywords[2].score | 0.7323244214057922 |
| keywords[2].display_name | Endocrinology |
| keywords[3].id | https://openalex.org/keywords/adipose-tissue |
| keywords[3].score | 0.6901392936706543 |
| keywords[3].display_name | Adipose tissue |
| keywords[4].id | https://openalex.org/keywords/inflammation |
| keywords[4].score | 0.5501433610916138 |
| keywords[4].display_name | Inflammation |
| keywords[5].id | https://openalex.org/keywords/soy-protein |
| keywords[5].score | 0.5351406335830688 |
| keywords[5].display_name | Soy protein |
| keywords[6].id | https://openalex.org/keywords/ketosis |
| keywords[6].score | 0.48660552501678467 |
| keywords[6].display_name | Ketosis |
| keywords[7].id | https://openalex.org/keywords/biology |
| keywords[7].score | 0.36154547333717346 |
| keywords[7].display_name | Biology |
| keywords[8].id | https://openalex.org/keywords/medicine |
| keywords[8].score | 0.33453619480133057 |
| keywords[8].display_name | Medicine |
| keywords[9].id | https://openalex.org/keywords/food-science |
| keywords[9].score | 0.13732397556304932 |
| keywords[9].display_name | Food science |
| keywords[10].id | https://openalex.org/keywords/diabetes-mellitus |
| keywords[10].score | 0.07793769240379333 |
| keywords[10].display_name | Diabetes mellitus |
| language | en |
| locations[0].id | doi:10.3390/nu17152428 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S110785341 |
| locations[0].source.issn | 2072-6643 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2072-6643 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Nutrients |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Nutrients |
| locations[0].landing_page_url | https://doi.org/10.3390/nu17152428 |
| locations[1].id | pmid:40806013 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Nutrients |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40806013 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:12348106 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Nutrients |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12348106 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5035644582 |
| authorships[0].author.orcid | https://orcid.org/0000-0003-2288-4751 |
| authorships[0].author.display_name | Weide Li |
| authorships[0].countries | TW |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I114150738 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| authorships[0].institutions[0].id | https://openalex.org/I114150738 |
| authorships[0].institutions[0].ror | https://ror.org/04je98850 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I114150738 |
| authorships[0].institutions[0].country_code | TW |
| authorships[0].institutions[0].display_name | Fu Jen Catholic University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Wen-Keng Li |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| authorships[1].author.id | https://openalex.org/A5018664650 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | I-Ting Wu |
| authorships[1].countries | TW |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I114150738 |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| authorships[1].institutions[0].id | https://openalex.org/I114150738 |
| authorships[1].institutions[0].ror | https://ror.org/04je98850 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I114150738 |
| authorships[1].institutions[0].country_code | TW |
| authorships[1].institutions[0].display_name | Fu Jen Catholic University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | I-Ting Wu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| authorships[2].author.id | https://openalex.org/A5089696842 |
| authorships[2].author.orcid | https://orcid.org/0000-0003-0723-3002 |
| authorships[2].author.display_name | Wan-Ju Yeh |
| authorships[2].countries | TW |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I134161618 |
| authorships[2].affiliations[0].raw_affiliation_string | Graduate Program of Nutrition Science, National Taiwan Normal University, Taipei 116, Taiwan |
| authorships[2].institutions[0].id | https://openalex.org/I134161618 |
| authorships[2].institutions[0].ror | https://ror.org/059dkdx38 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I134161618 |
| authorships[2].institutions[0].country_code | TW |
| authorships[2].institutions[0].display_name | National Taiwan Normal University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Wan-Ju Yeh |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Graduate Program of Nutrition Science, National Taiwan Normal University, Taipei 116, Taiwan |
| authorships[3].author.id | https://openalex.org/A5084875777 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-0484-4708 |
| authorships[3].author.display_name | Wen‐Chih Huang |
| authorships[3].countries | TW |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210102996 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Anatomical Pathology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan |
| authorships[3].institutions[0].id | https://openalex.org/I4210102996 |
| authorships[3].institutions[0].ror | https://ror.org/019tq3436 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210102996 |
| authorships[3].institutions[0].country_code | TW |
| authorships[3].institutions[0].display_name | Far Eastern Memorial Hospital |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Wen-Chih Huang |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Anatomical Pathology, Far Eastern Memorial Hospital, New Taipei City 220, Taiwan |
| authorships[4].author.id | https://openalex.org/A5078195609 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-3733-4269 |
| authorships[4].author.display_name | Hsin‐Yi Yang |
| authorships[4].countries | TW |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I114150738 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| authorships[4].institutions[0].id | https://openalex.org/I114150738 |
| authorships[4].institutions[0].ror | https://ror.org/04je98850 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I114150738 |
| authorships[4].institutions[0].country_code | TW |
| authorships[4].institutions[0].display_name | Fu Jen Catholic University |
| authorships[4].author_position | last |
| authorships[4].raw_author_name | Hsin-Yi Yang |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Department of Nutritional Science, Fu Jen Catholic University, New Taipei City 242, Taiwan |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.3390/nu17152428 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Effects of Soy Protein on Liver and Adipose Tissue Inflammation and Gut Microbiota in Mice Fed with Ketogenic Diets |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12267 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2737 |
| primary_topic.subfield.display_name | Physiology |
| primary_topic.display_name | Diet and metabolism studies |
| related_works | https://openalex.org/W2594030107, https://openalex.org/W2339088835, https://openalex.org/W3031052339, https://openalex.org/W2046919688, https://openalex.org/W2410147713, https://openalex.org/W2016800677, https://openalex.org/W4200019690, https://openalex.org/W4238756701, https://openalex.org/W2039975432, https://openalex.org/W2335496918 |
| cited_by_count | 0 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/nu17152428 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S110785341 |
| best_oa_location.source.issn | 2072-6643 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2072-6643 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | Nutrients |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Nutrients |
| best_oa_location.landing_page_url | https://doi.org/10.3390/nu17152428 |
| primary_location.id | doi:10.3390/nu17152428 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S110785341 |
| primary_location.source.issn | 2072-6643 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2072-6643 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Nutrients |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Nutrients |
| primary_location.landing_page_url | https://doi.org/10.3390/nu17152428 |
| publication_date | 2025-07-25 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W2341244791, https://openalex.org/W4206203078, https://openalex.org/W2811003389, https://openalex.org/W2615179214, https://openalex.org/W3088983709, https://openalex.org/W4402322505, https://openalex.org/W4378069961, https://openalex.org/W2889049588, https://openalex.org/W2541889639, https://openalex.org/W2292082921, https://openalex.org/W4388699343, https://openalex.org/W2982039527, https://openalex.org/W2165028825, https://openalex.org/W6606940768, https://openalex.org/W2168526937, https://openalex.org/W1541292363, https://openalex.org/W2344306379, https://openalex.org/W2110065044, https://openalex.org/W2133856765, https://openalex.org/W2065949094, https://openalex.org/W2081262717, https://openalex.org/W1994365118, https://openalex.org/W2053312248, https://openalex.org/W4293384843, https://openalex.org/W3155756670, https://openalex.org/W3135534580, https://openalex.org/W2107290206, https://openalex.org/W2024298957, https://openalex.org/W2065278560, https://openalex.org/W2004367352, https://openalex.org/W2041225327, https://openalex.org/W6638923802, https://openalex.org/W3012110397, https://openalex.org/W1995360022, https://openalex.org/W3128644041, https://openalex.org/W3214558294, https://openalex.org/W4221025084, https://openalex.org/W2802657923, https://openalex.org/W1511627718, https://openalex.org/W2343856733, https://openalex.org/W2132596222, https://openalex.org/W4249383371, https://openalex.org/W1585651039, https://openalex.org/W2930124576, https://openalex.org/W2792952980, https://openalex.org/W3212031021, https://openalex.org/W3162126872, https://openalex.org/W2887435293, https://openalex.org/W2766230324, https://openalex.org/W2568569100, https://openalex.org/W2970854520, https://openalex.org/W171326655 |
| referenced_works_count | 52 |
| abstract_inverted_index.6 | 106, 133 |
| abstract_inverted_index.C | 170, 187 |
| abstract_inverted_index.a | 6, 66, 90, 100, 146, 181, 194, 238 |
| abstract_inverted_index.12 | 97 |
| abstract_inverted_index.A. | 190 |
| abstract_inverted_index.In | 36, 172 |
| abstract_inverted_index.KD | 121, 137, 178, 207 |
| abstract_inverted_index.KS | 112, 139, 202 |
| abstract_inverted_index.an | 81 |
| abstract_inverted_index.as | 119 |
| abstract_inverted_index.in | 31, 55, 200, 237 |
| abstract_inverted_index.it | 252 |
| abstract_inverted_index.of | 9, 19, 41, 51, 108, 149 |
| abstract_inverted_index.on | 2, 27, 44 |
| abstract_inverted_index.or | 73 |
| abstract_inverted_index.to | 65 |
| abstract_inverted_index.F-B | 183, 196 |
| abstract_inverted_index.Soy | 234 |
| abstract_inverted_index.The | 111, 136 |
| abstract_inverted_index.and | 22, 46, 50, 99, 138, 151, 163, 193, 217, 221, 231 |
| abstract_inverted_index.but | 123, 251 |
| abstract_inverted_index.did | 241 |
| abstract_inverted_index.fat | 10, 156, 215 |
| abstract_inverted_index.fed | 89, 115 |
| abstract_inverted_index.for | 80, 128 |
| abstract_inverted_index.gut | 174, 232, 257 |
| abstract_inverted_index.had | 180 |
| abstract_inverted_index.may | 253 |
| abstract_inverted_index.not | 242 |
| abstract_inverted_index.soy | 28, 52, 76, 124 |
| abstract_inverted_index.the | 17, 39, 95, 104, 109, 116, 120, 131, 169, 173, 177, 186, 201, 206, 256 |
| abstract_inverted_index.was | 114, 126 |
| abstract_inverted_index.(C), | 69 |
| abstract_inverted_index.(KS) | 78 |
| abstract_inverted_index.Both | 84 |
| abstract_inverted_index.Mice | 61 |
| abstract_inverted_index.diet | 68, 71, 86, 93, 102, 118, 240 |
| abstract_inverted_index.from | 244 |
| abstract_inverted_index.have | 12, 254 |
| abstract_inverted_index.last | 105, 132 |
| abstract_inverted_index.mass | 216 |
| abstract_inverted_index.same | 117 |
| abstract_inverted_index.than | 185 |
| abstract_inverted_index.they | 225 |
| abstract_inverted_index.this | 37 |
| abstract_inverted_index.were | 58, 62, 88, 198, 226 |
| abstract_inverted_index.with | 5, 75, 168, 205, 228 |
| abstract_inverted_index.(KD), | 72 |
| abstract_inverted_index.NLRP3 | 164, 223 |
| abstract_inverted_index.blood | 153 |
| abstract_inverted_index.diets | 4, 33, 43, 57, 212 |
| abstract_inverted_index.first | 96 |
| abstract_inverted_index.group | 113, 179, 203 |
| abstract_inverted_index.lipid | 20 |
| abstract_inverted_index.lower | 152, 195 |
| abstract_inverted_index.mass, | 157 |
| abstract_inverted_index.noted | 199 |
| abstract_inverted_index.ratio | 184, 197 |
| abstract_inverted_index.weeks | 98, 107 |
| abstract_inverted_index.IL-1β | 161 |
| abstract_inverted_index.casein | 129, 245 |
| abstract_inverted_index.differ | 243 |
| abstract_inverted_index.during | 94, 103, 130 |
| abstract_inverted_index.group, | 122 |
| abstract_inverted_index.group. | 171, 188, 208 |
| abstract_inverted_index.groups | 79, 87, 140 |
| abstract_inverted_index.higher | 7, 142, 147, 182 |
| abstract_inverted_index.plasma | 143 |
| abstract_inverted_index.remain | 34 |
| abstract_inverted_index.study, | 38 |
| abstract_inverted_index.tissue | 23, 48, 159, 219, 249 |
| abstract_inverted_index.weeks. | 134 |
| abstract_inverted_index.18-week | 82 |
| abstract_inverted_index.Greater | 189 |
| abstract_inverted_index.Studies | 1 |
| abstract_inverted_index.TNF-α, | 160 |
| abstract_inverted_index.adipose | 47, 158, 218 |
| abstract_inverted_index.altered | 255 |
| abstract_inverted_index.control | 67 |
| abstract_inverted_index.effects | 40 |
| abstract_inverted_index.hepatic | 45, 229 |
| abstract_inverted_index.levels, | 162 |
| abstract_inverted_index.levels; | 145 |
| abstract_inverted_index.protein | 29, 53, 77, 125, 165, 235 |
| abstract_inverted_index.results | 15 |
| abstract_inverted_index.studies | 26 |
| abstract_inverted_index.Although | 210 |
| abstract_inverted_index.Methods: | 60 |
| abstract_inverted_index.Results: | 135 |
| abstract_inverted_index.assigned | 64 |
| abstract_inverted_index.compared | 167, 204 |
| abstract_inverted_index.glucose, | 154 |
| abstract_inverted_index.high-fat | 92 |
| abstract_inverted_index.limited. | 35 |
| abstract_inverted_index.randomly | 63 |
| abstract_inverted_index.revealed | 13 |
| abstract_inverted_index.abundance | 192 |
| abstract_inverted_index.analysis, | 176 |
| abstract_inverted_index.decreased | 213 |
| abstract_inverted_index.exhibited | 141 |
| abstract_inverted_index.incidence | 148 |
| abstract_inverted_index.ketogenic | 3, 32, 42, 56, 70, 74, 85, 101, 211, 239 |
| abstract_inverted_index.modulated | 222 |
| abstract_inverted_index.regarding | 16, 247 |
| abstract_inverted_index.associated | 227 |
| abstract_inverted_index.dysbiosis. | 233 |
| abstract_inverted_index.expression | 166 |
| abstract_inverted_index.mesenteric | 155, 214 |
| abstract_inverted_index.metabolism | 21 |
| abstract_inverted_index.microbiota | 175 |
| abstract_inverted_index.modulation | 18 |
| abstract_inverted_index.percentage | 8 |
| abstract_inverted_index.Background: | 0 |
| abstract_inverted_index.composition | 11 |
| abstract_inverted_index.conflicting | 14 |
| abstract_inverted_index.consumption | 30, 236, 246 |
| abstract_inverted_index.experiment. | 83, 110 |
| abstract_inverted_index.expression, | 224 |
| abstract_inverted_index.microbiota. | 258 |
| abstract_inverted_index.muciniphila | 191 |
| abstract_inverted_index.replacement | 54 |
| abstract_inverted_index.substituted | 127 |
| abstract_inverted_index.Conclusions: | 209 |
| abstract_inverted_index.Furthermore, | 25 |
| abstract_inverted_index.diet-induced | 248 |
| abstract_inverted_index.inflammation | 49, 220, 230 |
| abstract_inverted_index.inflammation, | 250 |
| abstract_inverted_index.inflammation. | 24 |
| abstract_inverted_index.investigated. | 59 |
| abstract_inverted_index.hyperlipidemia; | 150 |
| abstract_inverted_index.low-carbohydrate, | 91 |
| abstract_inverted_index.β-hydroxybutyrate | 144 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5078195609 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 5 |
| corresponding_institution_ids | https://openalex.org/I114150738 |
| citation_normalized_percentile.value | 0.39808437 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |