Kidney360 • Vol 4 • No 4
Effects of Spironolactone on Arrhythmias in Hemodialysis Patients: Secondary Results of the SPin-D Randomized Controlled Trial
February 2023 • Finnian R. Mc Causland, Jesse Y. Hsu, Jonathan Himmelfarb, T. Alp İkizler, Dominic S. Raj, Rajnish Mehrotra, Sushrut S. Waikar, Paul L. Kimmel, Alan …
Key Points The effects of spironolactone on arrhythmia in patients receiving maintenance hemodialysis are unclear. In these post hoc analyses, spironolactone resulted in a higher frequency of bradycardia and conduction blocks, compared with placebo. Close monitoring may be warranted for patients on maintenance hemodialysis receiving MRAs, while definitive trial results are awaited. Background Patients receiving maintenance hemodialysis (HD) have a high incidence of cardiovascular events, including arrhythmia and s…